DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ds and pcdh1

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	XP_012813865.1	Gene:	pcdh1 / 100124722	XenbaseID:	XB-GENE-983603	Length:	1248	Species:	Xenopus tropicalis

Alignment Length:	1407	Identity:	341/1407 - (24%)
Similarity:	515/1407 - (36%)	Gaps:	432/1407 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   424 PDSKTEYANVNVTLNGGDGHFALTTRDNSIYLVIVHLPLDREIVSN-----------YTLSVVAT 477
            ||||..|     .|..|..:..:..:...||  .....:|||.:..           ....|..|
Frog    93 PDSKHLY-----KLELGHPYLRVDGKTGDIY--TTETSIDRESLRECQNLEPGEKCFLEFEVSMT 150

  Fly   478 DKGTP-PLHASKSIFLRITDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTY 541
            |..:| |......|  .|.|:|||.|.|...:...::.|..:.|.......|.|||.|:|...:|
Frog   151 DLMSPVPRLLDGQI--EIMDINDNTPNFNSPVITLSIPENTNIGMLFPIPAATDRDSGVNGVSSY 213

  Fly   542 SLAETPETHAQW-FQI----DPQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTI 601
            .|...||....: .|:    |.:...:.....:|.|......||:..:|||.|..:|:|.:.::|
Frog   214 ELIVGPEAQDLFGLQVAEDQDEKQPQLIVMGMLDREQRDSYDLTIKVQDGGTPARASSALLRISI 278

  Fly   602 HDVNDNEPIFDQSFYNVSVAENEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVR--- 663
            .|.|||.|.|::..|...:.||.|:|..:|:|.|:|.|.||||.::|:.     |.....||
Frog   279 LDTNDNAPKFEKMAYEAELPENSPMGHSVLQVKANDSDQGVNAEIDYSF-----HQASDTVRRLL 338

  Fly   664 ---SASGEICIAGELDFERRSSYEFPVLATDRGGLSTTAMIKMQLT--DVNDNRPVFYPREYKVS 723
               .::|.|.:.|.:|.|...:.:|.|:|.|:|....||..::.:|  |.|||:||       :.
Frog   339 HLDRSTGLITVQGPIDREDVGTLKFSVVAKDKGANPKTARTQVTITIRDTNDNKPV-------IE 396

  Fly   724 LRESPKASSQASSTPIVAVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVR 788
            :|                         .||.|::      :.|:
Frog   397 IR-------------------------GFGLVTH------QGGV--------------------- 409

  Fly   789 TQPMHMLNISATDGGNLRSNADAVVFLSIIDAMQRPPIFEKARYNYYVKEDIPRGTVVGSVIAAS 853
                  .|||                                       ||:|
Frog   410 ------ANIS---------------------------------------EDVP------------ 417

  Fly   854 GDVAHRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEAKSQVLLNIQATLGEPPVYGHTQVN 918
                                   :||                              ||     ..
Frog   418 -----------------------VET------------------------------PV-----AL 424

  Fly   919 IEVEDVNDNAPEFEASMVRISVPESAELGAPLYAAHAHDKDSGSSGQVTYSLVKESGKGLFAIDA 983
            ::|.|:::........:|...||...:          ...|:||..:..|.|...:.
Frog   425 VQVSDIDEGVNAAVTCVVAGDVPFQLK----------QVSDTGSDSKKKYFLQTTTA-------- 471

  Fly   984 RSGHLILSQHLDYESSQRHTLIVTATDGGVPSLSTNLTILVDVQDVNDNPPVFEKDEYSVNVSES 1048
                      |||||.:.:|:.:.|.|.|.|.||:..::.|.|.|||||.|||.:....|...|:
Frog   472 ----------LDYESVKEYTIEIVAVDSGNPPLSSTNSLKVQVTDVNDNAPVFSQSLMEVVFPEN 526

  Fly  1049 RSINAQIIQVNASDLDTGNNARITYRIVDAGVDNVTNSISSSDVSQHFGIFPNSGWIYLRAPLDR 1113
            ..||..:::|:|:|.|:|.|:::.|.|:.   |.....|        |.|.|:||.|.:...|||
Frog   527 NDINDLVMEVSATDADSGPNSQLHYSILP---DPSARGI--------FSINPDSGQIRVNTVLDR 580

  Fly  1114 ETRDRYQLTVLATDNGTPAAHAKTRVIVRVLDANDNDPKFQKSKYEFRIEENLRRGSVVGVVTAS 1178
            |.|:.|...|:|.|.|.|:......|::.|||.|||||||..:.|.|.:.||:.|.|.||:||..
Frog   581 EQREHYDFHVVAVDKGIPSLKGTASVVITVLDRNDNDPKFMLNGYNFSVMENMPRLSPVGMVTVI 645

  Fly  1179 DLDLGENAAIRYSLLPINSSFQVHPVTGEISTREPLDRELRELYDLVVEARDQGTPVRSARVPVR 1243
            |.|.||||.|..|:.|.:..|.:...||.|.:....|||.:..|...::|.|.|.|.||:.|.|.
Frog   646 DADKGENAHIHLSVEPESGEFVIQNGTGTILSSISFDREHQSTYTFRLKAVDGGDPPRSSYVGVT 710

  Fly  1244 IHVSDVNDNAPEIADPQEDVVSVREEQP---PGTEVVRVRAVDRDHGQNASITYSIVKGRDSDGH 1305
            |:|.|.|||||.|..|..  :|.:...|   |||.|..|||.|.|.|.||.:.|||..|...:
Frog   711 INVLDENDNAPVIVVPSN--ISYKYLTPQTHPGTPVNWVRAEDMDTGINAELDYSIASGNPFE-- 771

  Fly  1306 GLFSIDPTSGVIRTRVVLDHEERSIYRLGVAASDGGNPPRETVRMLRVEVLDLNDNRPTFTSSSL 1370
             ||.|...:|.:.....:..:...::||.|..:|.|.|.|....::...:      ..|.|:.:|
Frog   772 -LFQISHNNGEVTLEKAIIRKHYGLHRLVVKVTDKGKPSRHGTALVHFYI------NETLTNQTL 829

  Fly  1371 VFRVREDAALGHVVGSISPIERPADVVRNSVEESFEDLRVTYTLNPLTKDLI-EAAFDIDRHSGN 1434
            |     :..|||                             ....||..|:. :..:::.:...|
Frog   830 V-----ETLLGH-----------------------------SQFTPLDIDIAGDPEYELSKQRSN 860

  Fly  1435 L------------------VVARLL-DREVQSEF---RLEIRALDTTASNNPQSSAITVKIEVAD 1477
            :                  ||||.. .:|.:|.:   :.|.:.|......| :::.|..|::
Frog   861 IIFGVITGIVAVILVIVVVVVARYCRQKEAKSGYQAGKKETKDLYAPKQGN-KNNKIKNKVK--- 921

  Fly  1478 VNDNAPEWPQDPIDLQVSEATPVGTIIHNFTATDADTGTNGDLQYRLIRYFPQLNESQEQAMSL- 1541
             ...:|: |..|::                  .|.:||....|::.|:.  ..:.:|....:.|
Frog   922 -KSKSPK-PPKPVE------------------EDEETGLQKSLKFNLMS--DSVGDSPRIHLPLN 964

  Fly  1542 -----------FRMDSLTGALSLQAPLDFEAVQEYLLIVQAL-----------------DQSSNV 1578
                       :|.:|...::.|| |....|.::: .:||.|                 ||.|:.
Frog   965 YPPGSPDLGRHYRSNSPLPSIQLQ-PQSPSASKKH-QVVQDLPATNTFVGTGDNNSTGSDQYSDY 1027

  Fly  1579 TERLQT------SVTVRLRILDANDHAPHFVSPN-----SSG---GKTASLFISDATRIGEVVAH 1629
            :.|..|      .:..|......::.||....|:     .||   .:|.|...|...|||.
Frog  1028 SYRTNTQKYNHKQLPHRRVTFSTSNQAPDIQDPSQHSYYDSGLEESETPSSKSSSGPRIGP---- 1088

  Fly  1630 IVAVDEDSGDNGQLTYEITGGNGEGRFRINSQTGIIELVKSLPPATEDVEKGGRFNLIIGAKDH- 1693
             :|:.||.       ||.|..:|......:.:|.:    :.||    ||...|..........|
Frog  1089 -LALPEDH-------YERTTPDGSIGEMEHPETDL----RPLP----DVAMTGNCTRECTEYGHS 1137

  Fly  1694 ------GQPEPK---KSSLNLHLIV----QGSH----NNPPR 1718
                  |||.|.   |::|.|...|    :||.    |..||
Frog  1138 DTCWMPGQPSPNRRPKNALKLSTFVPYQDKGSQEQIGNGNPR 1179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637
		Cadherin_repeat	291..389	CDD:206637
		Cadherin_repeat	406..500	CDD:206637	21/87 (24%)
		Cadherin_repeat	509..607	CDD:206637	27/102 (26%)
		Cadherin_repeat	616..711	CDD:206637	33/102 (32%)
		Cadherin_repeat	719..820	CDD:206637	8/100 (8%)
		Cadherin_repeat	832..927	CDD:206637	9/94 (10%)
		Cadherin_repeat	937..1032	CDD:206637	24/94 (26%)
		Cadherin_repeat	1040..1149	CDD:206637	36/108 (33%)
		Cadherin_repeat	1158..1252	CDD:206637	39/93 (42%)
		Cadherin_repeat	1263..1361	CDD:206637	29/100 (29%)
		Cadherin_repeat	1369..1481	CDD:206637	20/134 (15%)
		Cadherin_repeat	1489..1598	CDD:206637	23/143 (16%)
		Cadherin_repeat	1614..1710	CDD:206637	27/109 (25%)
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
pcdh1	XP_012813865.1	Cadherin_2	71..147	CDD:369785	12/60 (20%)
		Cadherin_repeat	180..284	CDD:206637	27/103 (26%)
		Cadherin_repeat	293..391	CDD:206637	33/102 (32%)
		Cadherin_repeat	409..510	CDD:206637	37/264 (14%)
		Cadherin_repeat	520..616	CDD:206637	36/106 (34%)
		Cadherin_repeat	625..719	CDD:206637	39/93 (42%)
		Cadherin_repeat	740..817	CDD:206637	27/79 (34%)
		Protocadherin	823..1036	CDD:369839	46/274 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9561
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000