DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and pcdh20

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_001093700.1	Gene:	pcdh20 / 100101710	XenbaseID:	XB-GENE-484153	Length:	894	Species:	Xenopus tropicalis

Alignment Length:	843	Identity:	258/843 - (30%)
Similarity:	387/843 - (45%)	Gaps:	92/843 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 HMLRSSLLILLAIVLLGSSQAASHDQERERKLEVFEGVAVDYQIGYIGDFGGID--SGPP--YII 113
            |:|   .|.|||.|.......||:.:..|....:.||:.....||.|||...:|  :.||  :.:
Frog    17 HLL---FLWLLAHVRGSLFSLASNSRATELLYTLQEGLPKGVHIGSIGDDLQLDVFADPPLSFSL 78

  Fly   114 VAEAGVETDLAIDRATGEIRT-KVKLDRETRASYSLVA-----------IPLS-GRNIRVLVTVK 165
            .::...|..:.::.:|||:.| ..:||||....:||||           :|.. .|.|:|.:.:.
Frog    79 ASKGLSEKYVNLNNSTGELCTSSEELDREALCPHSLVAQECVLLLDIIILPQEYFRLIKVKIAII 143

  Fly   166 DENDNAPTFPQTSMHIEFPENTPREVKRTL-LPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRE 229
            |.|||||.||...::|..|||.|...:..: .||.|.|......|.|.:|  :.:..|.|.....
Frog   144 DINDNAPHFPVPQIYISVPENAPVNTRIVIEHPAYDPDGGTNGVQTYRLV--DYHGVFTLDVEEN 206

  Fly   230 RDGVLYLDLQISGFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFAT 294
            ..|.....|.|.|.|||||...|...|.|.|||:|||.|..|::|.|.|||||.|.||.|:..||
Frog   207 ESGERTPYLIIMGPLDRETKAEYETTIIAEDGGSPPLVGSATLSILISDVNDNCPQFNASQINAT 271

  Fly   295 VPENATVGTSVLQVYASDTDADENGLVEYAINRR--QSDKEQMFRIDPRTGAIYINKALDFETKE 357
            :..|:|:||.|:.|:|.|.|...|.|:.||.:.|  |:.|| .|.:|...|.|.::|.:|..|.:
Frog   272 LYGNSTIGTQVVTVHAMDRDLGPNALITYAFSERVPQAVKE-YFHLDELKGIIKLSKRIDGSTVQ 335

  Fly   358 LHELVVVAKDHGEQPLETTAFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEF------- 415
            .|:|.::|...|..|...|.|:||.           .:.|...:..|:...:.:.|..
Frog   336 QHKLTILANGPGCIPAVITVFISIN-----------KITFRPPELIPRYIANEENGVIYLKELEP 389

  Fly   416 ----VARISVHDPDSKTEYANVNVTLNGGDGHFALTTRD--NSIYLVIVHLPLDREIVSNYTLSV 474
                :|..::.|||.|.:   ||..|. |.|.|.|:...  |:.||:.....||.|:..:|.::|
Frog   390 VHSPLAFFTIKDPDEKYQ---VNCYLE-GQGPFRLSAFKPYNNEYLLETTDALDYELKQSYNIAV 450

  Fly   475 VATDKGTPPLHASKSIF-LRITDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSA 538
            ||..:..   |..|.:. ::|.|.|||.|.|.:......:.|..:|...:.::.|.|.|...:..
Frog   451 VALSRDG---HQVKKLLKVQILDENDNSPVFTESTVEITIEENNEPNAFLAKLYATDADSNESGQ 512

  Fly   539 LTYSLAETPETHAQWFQIDPQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHD 603
            ::|.|.  |:. ..:|.:|..||:::..:.:|.|.:...:.||.|||.|.|...|.|||.:|:.|
Frog   513 VSYFLG--PDA-PSYFTLDSVTGILSVSTILDREEKEKYRFTVKARDAGFPSRESVATVHITVLD 574

  Fly   604 VNDNEPIFDQSFYNVSVAENEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGE 668
            .|||.|.|....::..|.||.|....|..:|.:|.|.|.|..:..:||.|   ...|.:.:..|.
Frog   575 KNDNNPRFISKDFSFFVPENFPGFGEIGVISVTDADSGQNGWIALSIGNG---SDIFVIDNGKGL 636

  Fly   669 ICIAGELDFERRSSYEFPVLATDRGG--LSTTAMIKMQLTDVNDNRP-VFYPREYKVSLRESPKA 730
            :.....||.|::|||...|.|.|.|.  ||:||.|.:.|.|||||.| |.:|:.....|...|
Frog   637 LRAKVSLDREQQSSYTLWVEAVDGGDPTLSSTAKITILLLDVNDNPPMVLFPQSNMSYLLVLP-- 699

  Fly   731 SSQASSTPIVAVVATDPDYGNFGQVSYRIVA--GNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMH 793
             |....:|:..|.|.|.|.|....::|.|:.  |.:...||||..||.|.:  .:.|.:....::
Frog   700 -STLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPKPESFRIDPITGNITL--EEALMINDCGLY 761

  Fly   794 MLNISATDGGNLRSNADAVVFLSIIDAMQRPPIFEKARYNYYVKEDIPRGTVVGSVIAASGDV 856
            .|.:..:|.|                  ...|:|.....|.:|.:.:...:.:.:::....|:
Frog   762 RLLVKVSDHG------------------YPEPLFSTVMVNLFVNDTVTNESYIETLLKKEPDI 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	21/73 (29%)
		Cadherin_repeat	178..282	CDD:206637	39/104 (38%)
		Cadherin_repeat	291..389	CDD:206637	35/99 (35%)
		Cadherin_repeat	406..500	CDD:206637	28/107 (26%)
		Cadherin_repeat	509..607	CDD:206637	28/97 (29%)
		Cadherin_repeat	616..711	CDD:206637	34/96 (35%)
		Cadherin_repeat	719..820	CDD:206637	23/102 (23%)
		Cadherin_repeat	832..927	CDD:206637	3/25 (12%)
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
pcdh20	NP_001093700.1	E_set	45..127	CDD:324323	23/81 (28%)
		Cadherin_repeat	156..259	CDD:206637	39/104 (38%)
		Cadherin_repeat	267..359	CDD:206637	33/92 (36%)
		Cadherin_repeat	381..474	CDD:206637	27/99 (27%)
		Cadherin_repeat	484..578	CDD:206637	28/96 (29%)
		Cadherin_repeat	587..681	CDD:206637	34/96 (35%)
		Cadherin_repeat	697..788	CDD:206637	26/113 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9561
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000