DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and LOC100006777

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	XP_021335004.1	Gene:	LOC100006777 / 100006777	-ID:	-	Length:	966	Species:	Danio rerio

Alignment Length:	896	Identity:	248/896 - (27%)
Similarity:	386/896 - (43%)	Gaps:	141/896 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 IGYIGDFGGIDSGP----PYIIVAEAGVETDLAIDRATGEIRTKVKLDRE------TRASYSLVA 150
            :|.|.:..|:|:..    .:.||:.|..:. |.::...|.:....::|||      ...|:.|..
Zfish    41 VGNIAEDLGLDTNKLSVRRFRIVSGAKRQY-LEVNLENGVLFVNERIDREELCEQNPYCSFHLQV 104

  Fly   151 I---PLSGRNIRVLVTVKDENDNAPTFPQTSMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYN 212
            :   ||  ...||.|.:.|.|||:|.||.:..:::..|:.....:..|..|:|||:...:.:.|.
Zfish   105 VIENPL--ELYRVEVEIFDVNDNSPVFPWSEFNLDISESAAPGSRFPLESAQDLDVADNSLRSYL 167

  Fly   213 IVSGNVNDAFRLSSHRERDGVLYLDLQISGFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQ 277
            :   :||:.|.|......||..:.:|.:...||||....:.:::.|:|||:|...|...:|||:.
Zfish   168 L---SVNEHFVLDVQTRSDGSKFAELILESPLDREQQKTHLMVLTAVDGGSPERSGTAQINITVL 229

  Fly   278 DVNDNQPIFNQSRYFATVPENATVGTSVLQVYASDTDADENGLVEYAINRRQSDK-EQMFRIDPR 341
            |.|||.|:|:|:.|...:.|||..||.|:::.|:|.|...||.:.|:.:.....: .::|.:|.|
Zfish   230 DANDNAPVFDQNFYKVRLAENAPRGTVVIKLNATDLDEGPNGEITYSFSGHAPMRVRELFSVDSR 294

  Fly   342 TGAIYINKALDFETKELHELVVVAKDHGEQPLETTAFVSIRVTDVNDNQPTINVIFLSDDASPKI 406
            ||.|.:...:|:|...:||:.|.|||.|...:.....|.:.:.|||||.|  .||..|  .|..:
Zfish   295 TGEIKVKGLIDYEKARMHEIYVQAKDKGPSAVAVHCKVMVNIIDVNDNLP--EVILTS--VSTPV 355

  Fly   407 SESAQPGEFVARISVHDPDSKTEYANVNVTLNGGDGH--FALTTRDNSIYLVIVHLPLDREIVSN 469
            .|.|.||..:|.|||.|.|| .|..||:..:   ..|  |.|.:...:.|.::....||||.:|.
Zfish   356 QEDAPPGTVIAVISVMDKDS-GENGNVDCEI---PHHVPFQLHSSFKNYYTLVTCDFLDRESISE 416

  Fly   470 YTLSVVATDKGTPPLHASKSIFLRITDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEG 534
            |.:::.|.|.|:|||...|:|.::::|:|||.|.|:|..|...:.|...||.|:..:.|.|.|..
Zfish   417 YNITLTARDMGSPPLFTRKTILVQVSDINDNAPRFKQPSYTVYLTENNAPGASICTITAQDADAD 481

  Fly   535 LNSALTYSLAETPETH----AQWFQIDPQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTA 595
            .||.|:||:.|. :.|    :.:..|:...|.|......|.|.....|:.|.|.|.|.|||.:..
Zfish   482 QNSYLSYSILEN-DIHGMPVSTYVSINSDNGNIYALRSFDHEQLRNFQIVVQAEDAGFPPLRANV 545

  Fly   596 TVLVTIHDVNDNEPIF------DQSFYNVSVAENEPVGRCILKVSASDPDCGVNAMVNYTIGEGF 654
            ||.|.:.|.|||.|:.      :.:...|.|......|..:.|::|.|.|.|.|:.:.|.:.:.
Zfish   546 TVNVFVLDQNDNPPVIVSPMPENDTAAVVVVPRYVDAGYLVAKITAMDADAGQNSRLFYEVLQA- 609

  Fly   655 KHLTEFEVRSASGEI-CIAGELDFERRSSYEFPVLATDRG--GLSTTAMIKMQLTDVNDNRPVFY 716
            ...:.|.|...:||| .|...:|.:.| .:...||..|.|  .||.||.|.:.:.|
Zfish   610 TDASLFSVALYTGEIRTIRRLMDNDPR-RHRLVVLVKDNGQPPLSATASIMLSVVD--------- 664

  Fly   717 PREYKVSLRESPKASSQASSTPIVAVVATDPDYG---------NFGQVSYRIVA----------- 761
                           |...|:|....:|..|.|.         :.|.||:..:.
Zfish   665 ---------------SAPESSPDFGDLALSPHYRSNLTLYLIVSLGAVSFTFLVAIIVLASIKGC 714

  Fly   762 --GNEAGIFRIDRSTGEIFVVRPDMLSVRTQP----MHMLNISATDGGNL--------RSNADAV 812
              ||....|....|..|  |::...|::...|    ....|.:...|.|.        .|:....
Zfish   715 KDGNSCCGFHTKDSESE--VIKKSNLNIHISPGSIKRDQFNANNPMGPNYCYKMCLTPESSKSDF 777

  Fly   813 VFLSIIDAMQRP--PIFEKARYNYYVKEDIPRGTVVGSVIAASGDVAHR----SPVRYSIYSGDP 871
            :||       :|  |....:|.|  :|| |...|:..|  :.|..::.|    ||..:.
Zfish   778 MFL-------KPCSPTGTSSRNN--IKE-IENKTLTWS--SGSHSISTRNGTTSPNEFK------ 824

  Fly   872 DGYFSIETNSGNIRIAKPLDHEAKSQVLLNIQATLGEPPV-----YGHTQV 917
                  :.|.........|::..:|...||...||....:     |.:|.|
Zfish   825 ------QANRDRTLTKNQLNYTYRSNTPLNTGRTLQRRLIQDSDNYSYTSV 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	19/69 (28%)
		Cadherin_repeat	178..282	CDD:206637	29/103 (28%)
		Cadherin_repeat	291..389	CDD:206637	32/98 (33%)
		Cadherin_repeat	406..500	CDD:206637	34/95 (36%)
		Cadherin_repeat	509..607	CDD:206637	33/101 (33%)
		Cadherin_repeat	616..711	CDD:206637	28/97 (29%)
		Cadherin_repeat	719..820	CDD:206637	23/134 (17%)
		Cadherin_repeat	832..927	CDD:206637	20/95 (21%)
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
LOC100006777	XP_021335004.1	Cadherin_2	26..108	CDD:311943	14/67 (21%)
		Cadherin_repeat	133..234	CDD:206637	29/103 (28%)
		Cadherin_repeat	243..342	CDD:206637	32/98 (33%)
		Cadherin_repeat	355..447	CDD:206637	34/95 (36%)
		Cadherin_repeat	455..557	CDD:206637	33/102 (32%)
		Cadherin_repeat	573..664	CDD:206637	27/92 (29%)
		Cadherin_C_2	685..781	CDD:318652	17/104 (16%)
		Cadherin_tail	<884..950	CDD:318236
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10294
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000