DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ds and si:ch211-199f5.1

DIOPT Version :9

Sequence 1:NP_001285551.1 Gene:ds / 33245 FlyBaseID:FBgn0284247 Length:3556 Species:Drosophila melanogaster
Sequence 2:XP_001341908.5 Gene:si:ch211-199f5.1 / 100002026 ZFINID:ZDB-GENE-120215-215 Length:970 Species:Danio rerio


Alignment Length:931 Identity:239/931 - (25%)
Similarity:367/931 - (39%) Gaps:205/931 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   130 GEIRTKVKLDRETRASYSLVAIPLSGRNIRVLVT-------------------VKDENDNAPTFP 175
            |.:..:.::|||.          :..||.|.::|                   |.|.|||:|.||
Zfish    82 GRLTAEERVDRER----------ICKRNPRCVITFDVAFVSAEQFELFHVEVEVLDVNDNSPEFP 136

  Fly   176 QTSMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERDGVLYLDLQI 240
            :....:|..|:.....:..|..|.|.|:...:.|.|.:   :.|..|.:......|||.|.:|.:
Zfish   137 RAECTVEISESAALGTRIALDAAEDSDVGSNSIQSYEL---SENSHFSIDVITRVDGVKYAELVL 198

  Fly   241 SGFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATVGTSV 305
            ...||||....::|.:.|.|||.||..|...|.:.::|.|||.|:|:.|.|...|||:..|...:
Zfish   199 VKELDREARAFFALKLVAADGGHPPRSGSTNVTVKVKDANDNSPLFDHSHYSVDVPEDTPVEALL 263

  Fly   306 LQVYASDTDADENGLVEYAINRR-QSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHG 369
            |.:.|.|.|...||.|.|...:: .::..|:|::|.:||.:.:...:|:|.:..:|:.|.|.|.|
Zfish   264 LDLNAIDPDEGLNGQVVYEFGKQVTTEIRQLFKLDYKTGYLTLQSPVDYEDETTYEIDVQATDLG 328

  Fly   370 EQPLETTAFVSIRVTDVNDNQPTINVIFLSD--DASPKISESAQPGEFVARISVHDPDSKTEYAN 432
            ..|:.:...:.|.:.|||||.|.|.:..::.  |....:||:..|...||.||:.|.|:... ..
Zfish   329 HNPVPSVCKIIINIRDVNDNPPEIIITSITSVTDGVAHVSEATGPDILVALISIKDKDTGAN-GQ 392

  Fly   433 VNVTLNGGDGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHASKSIFLRITDV 497
            |:.|||||.|:|.|.......|.::...|||||.::.|.|:|||.|.|.|||.......:|:|||
Zfish   393 VSCTLNGGHGNFRLKRAYEGSYTIVTMAPLDREKIAEYNLTVVAEDFGVPPLRTVTQYIIRLTDV 457

  Fly   498 NDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETHAQWFQIDPQTGL 562
            |||.|.|...:|...:.|...|||.:..:||.|:|.|||..:||.|.::.......|.|..|.|.
Zfish   458 NDNAPAFSAKIYEGFIEENQLPGTYITTILASDQDSGLNGEITYELFDSDTNSVSRFAIMNQAGN 522

  Fly   563 ITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFD-----QSFYNVSVAE 622
            :......:.|......|.|.|.|.|.|.|.:.|.:::.:.|.|||.|...     .....:.:..
Zfish   523 VYALQSFNYEVTKRLDLRVQASDRGWPQLHNNAILIINVVDQNDNTPFITHPPLINGSAEIQLPR 587

  Fly   623 NEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFERRSSYEFPV 687
            :.|.|..:.::.|.|.|.|:||.:.|.|.:|...  .|.:...:|||.|..::.::....::..|
Zfish   588 DAPPGYIVTRIIAKDSDAGLNAELTYKIYDGGDF--GFAIDPNTGEIYINRKITYDEYDLWKVLV 650

  Fly   688 LATDRG--GLSTTAMIKMQLTDVNDNRPVFY-------PREYKV--------------------- 722
            ...|.|  ..::||.|...||:...:...||       |:::.:                     
Zfish   651 TVNDNGQPSQTSTATIHFTLTESAPSNGNFYDEREEDEPKQWTLVLILALTTSSLLFLAILSFIL 715

  Fly   723 --SLRESPKASSQASSTPIVAVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDML 785
              |.:.|||.|.....       |.|..|.:           .:..:..|...|..:|       
Zfish   716 CKSRKNSPKGSDDLPE-------ALDIPYSD-----------EKNSVSMISNQTANVF------- 755

  Fly   786 SVRTQPMHMLNISATDGGNLRSNADAVVFLSIIDAMQRPPIFEKARYNYYVKEDIPRGTVVGSVI 850
              .|...|...|.:.:..:....|.|.||      .:.|..|:.                     
Zfish   756 --ETHTFHSTTIDSPEKLHSSVQATAEVF------NETPQTFKS--------------------- 791

  Fly   851 AASGDVAHRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEAKSQVLLNIQATLGEPPVYGHT 915
                        :|...:||.|||.::                                |.||..
Zfish   792 ------------KYRSVAGDIDGYSTL--------------------------------PGYGKD 812

  Fly   916 QVN-IEVEDVNDNAPEFEASMVRISVPESAELGAPLYAAHAHDKDSG--------SSGQVTYSLV 971
            ... |.|...|        ||:.|:|.:....|          ||||        |...::..|.
Zfish   813 SARPITVWKGN--------SMMTIAVRDPQISG----------KDSGKGDSDVNDSDSDISEGLK 859

  Fly   972 KE--SGKGLFAIDARS---GH 987
            |:  :.|||:|..:..   ||
Zfish   860 KDYTTYKGLWACTSECRVLGH 880

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsNP_001285551.1 CA 111..172 CDD:214520 13/60 (22%)
Cadherin_repeat 178..282 CDD:206637 30/103 (29%)
Cadherin_repeat 291..389 CDD:206637 30/98 (31%)
Cadherin_repeat 406..500 CDD:206637 39/93 (42%)
Cadherin_repeat 509..607 CDD:206637 30/97 (31%)
Cadherin_repeat 616..711 CDD:206637 24/96 (25%)
Cadherin_repeat 719..820 CDD:206637 18/123 (15%)
Cadherin_repeat 832..927 CDD:206637 12/95 (13%)
Cadherin_repeat 937..1032 CDD:206637 16/64 (25%)
Cadherin_repeat 1040..1149 CDD:206637
Cadherin_repeat 1158..1252 CDD:206637
Cadherin_repeat 1263..1361 CDD:206637
Cadherin_repeat 1369..1481 CDD:206637
Cadherin_repeat 1489..1598 CDD:206637
Cadherin_repeat 1614..1710 CDD:206637
Cadherin_repeat 1723..1843 CDD:206637
Cadherin_repeat 1853..1948 CDD:206637
Cadherin_repeat 1957..2053 CDD:206637
Cadherin_repeat 2061..2154 CDD:206637
Cadherin_repeat 2170..2318 CDD:206637
Cadherin_repeat 2326..2424 CDD:206637
Cadherin_repeat 2434..2528 CDD:206637
Cadherin_repeat 2549..2641 CDD:206637
Cadherin_repeat 2652..2748 CDD:206637
Cadherin_repeat 2758..2858 CDD:206637
Cadherin_repeat 2866..2960 CDD:206637
Cadherin_repeat 2985..3071 CDD:206637
si:ch211-199f5.1XP_001341908.5 E_set 26..108 CDD:298831 8/35 (23%)
Cadherin_repeat 141..240 CDD:206637 30/101 (30%)
Cadherin_repeat 248..348 CDD:206637 30/99 (30%)
Cadherin_repeat 364..460 CDD:206637 39/96 (41%)
Cadherin_repeat 468..567 CDD:206637 30/98 (31%)
Cadherin_repeat 582..671 CDD:206637 22/90 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 62 1.000 Domainoid score I10294
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

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