DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and si:ch211-199f5.1

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	XP_001341908.5	Gene:	si:ch211-199f5.1 / 100002026	ZFINID:	ZDB-GENE-120215-215	Length:	970	Species:	Danio rerio

Alignment Length:	931	Identity:	239/931 - (25%)
Similarity:	367/931 - (39%)	Gaps:	205/931 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 GEIRTKVKLDRETRASYSLVAIPLSGRNIRVLVT-------------------VKDENDNAPTFP 175
            |.:..:.::|||.          :..||.|.::|                   |.|.|||:|.||
Zfish    82 GRLTAEERVDRER----------ICKRNPRCVITFDVAFVSAEQFELFHVEVEVLDVNDNSPEFP 136

  Fly   176 QTSMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERDGVLYLDLQI 240
            :....:|..|:.....:..|..|.|.|:...:.|.|.:   :.|..|.:......|||.|.:|.:
Zfish   137 RAECTVEISESAALGTRIALDAAEDSDVGSNSIQSYEL---SENSHFSIDVITRVDGVKYAELVL 198

  Fly   241 SGFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATVGTSV 305
            ...||||....::|.:.|.|||.||..|...|.:.::|.|||.|:|:.|.|...|||:..|...:
Zfish   199 VKELDREARAFFALKLVAADGGHPPRSGSTNVTVKVKDANDNSPLFDHSHYSVDVPEDTPVEALL 263

  Fly   306 LQVYASDTDADENGLVEYAINRR-QSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHG 369
            |.:.|.|.|...||.|.|...:: .::..|:|::|.:||.:.:...:|:|.:..:|:.|.|.|.|
Zfish   264 LDLNAIDPDEGLNGQVVYEFGKQVTTEIRQLFKLDYKTGYLTLQSPVDYEDETTYEIDVQATDLG 328

  Fly   370 EQPLETTAFVSIRVTDVNDNQPTINVIFLSD--DASPKISESAQPGEFVARISVHDPDSKTEYAN 432
            ..|:.:...:.|.:.|||||.|.|.:..::.  |....:||:..|...||.||:.|.|:... ..
Zfish   329 HNPVPSVCKIIINIRDVNDNPPEIIITSITSVTDGVAHVSEATGPDILVALISIKDKDTGAN-GQ 392

  Fly   433 VNVTLNGGDGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHASKSIFLRITDV 497
            |:.|||||.|:|.|.......|.::...|||||.::.|.|:|||.|.|.|||.......:|:|||
Zfish   393 VSCTLNGGHGNFRLKRAYEGSYTIVTMAPLDREKIAEYNLTVVAEDFGVPPLRTVTQYIIRLTDV 457

  Fly   498 NDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETHAQWFQIDPQTGL 562
            |||.|.|...:|...:.|...|||.:..:||.|:|.|||..:||.|.::.......|.|..|.|.
Zfish   458 NDNAPAFSAKIYEGFIEENQLPGTYITTILASDQDSGLNGEITYELFDSDTNSVSRFAIMNQAGN 522

  Fly   563 ITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFD-----QSFYNVSVAE 622
            :......:.|......|.|.|.|.|.|.|.:.|.:::.:.|.|||.|...     .....:.:..
Zfish   523 VYALQSFNYEVTKRLDLRVQASDRGWPQLHNNAILIINVVDQNDNTPFITHPPLINGSAEIQLPR 587

  Fly   623 NEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFERRSSYEFPV 687
            :.|.|..:.::.|.|.|.|:||.:.|.|.:|...  .|.:...:|||.|..::.::....::..|
Zfish   588 DAPPGYIVTRIIAKDSDAGLNAELTYKIYDGGDF--GFAIDPNTGEIYINRKITYDEYDLWKVLV 650

  Fly   688 LATDRG--GLSTTAMIKMQLTDVNDNRPVFY-------PREYKV--------------------- 722
            ...|.|  ..::||.|...||:...:...||       |:::.:
Zfish   651 TVNDNGQPSQTSTATIHFTLTESAPSNGNFYDEREEDEPKQWTLVLILALTTSSLLFLAILSFIL 715

  Fly   723 --SLRESPKASSQASSTPIVAVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDML 785
              |.:.|||.|.....       |.|..|.:           .:..:..|...|..:|
Zfish   716 CKSRKNSPKGSDDLPE-------ALDIPYSD-----------EKNSVSMISNQTANVF------- 755

  Fly   786 SVRTQPMHMLNISATDGGNLRSNADAVVFLSIIDAMQRPPIFEKARYNYYVKEDIPRGTVVGSVI 850
              .|...|...|.:.:..:....|.|.||      .:.|..|:.
Zfish   756 --ETHTFHSTTIDSPEKLHSSVQATAEVF------NETPQTFKS--------------------- 791

  Fly   851 AASGDVAHRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEAKSQVLLNIQATLGEPPVYGHT 915
                        :|...:||.|||.::                                |.||..
Zfish   792 ------------KYRSVAGDIDGYSTL--------------------------------PGYGKD 812

  Fly   916 QVN-IEVEDVNDNAPEFEASMVRISVPESAELGAPLYAAHAHDKDSG--------SSGQVTYSLV 971
            ... |.|...|        ||:.|:|.:....|          ||||        |...::..|.
Zfish   813 SARPITVWKGN--------SMMTIAVRDPQISG----------KDSGKGDSDVNDSDSDISEGLK 859

  Fly   972 KE--SGKGLFAIDARS---GH 987
            |:  :.|||:|..:..   ||
Zfish   860 KDYTTYKGLWACTSECRVLGH 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	13/60 (22%)
		Cadherin_repeat	178..282	CDD:206637	30/103 (29%)
		Cadherin_repeat	291..389	CDD:206637	30/98 (31%)
		Cadherin_repeat	406..500	CDD:206637	39/93 (42%)
		Cadherin_repeat	509..607	CDD:206637	30/97 (31%)
		Cadherin_repeat	616..711	CDD:206637	24/96 (25%)
		Cadherin_repeat	719..820	CDD:206637	18/123 (15%)
		Cadherin_repeat	832..927	CDD:206637	12/95 (13%)
		Cadherin_repeat	937..1032	CDD:206637	16/64 (25%)
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
si:ch211-199f5.1	XP_001341908.5	E_set	26..108	CDD:298831	8/35 (23%)
		Cadherin_repeat	141..240	CDD:206637	30/101 (30%)
		Cadherin_repeat	248..348	CDD:206637	30/99 (30%)
		Cadherin_repeat	364..460	CDD:206637	39/96 (41%)
		Cadherin_repeat	468..567	CDD:206637	30/98 (31%)
		Cadherin_repeat	582..671	CDD:206637	22/90 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10294
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000