DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2839 and MRC2

DIOPT Version :9

Sequence 1:	NP_608540.1	Gene:	CG2839 / 33244	FlyBaseID:	FBgn0031273	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_006030.2	Gene:	MRC2 / 9902	HGNCID:	16875	Length:	1479	Species:	Homo sapiens

Alignment Length:	298	Identity:	67/298 - (22%)
Similarity:	113/298 - (37%)	Gaps:	57/298 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 CNVFAENDILQDPLIS-------SYDRLKKLGEMCLIDILPILENISEQQ-----KEGYTANFRI 70
            |..|.:.|.|.|....       |:.......|....|:|.|.| |.||.     ..||::...|
Human   235 CETFWDKDQLTDSCYQFNFQSTLSWREAWASCEQQGADLLSITE-IHEQTYINGLLTGYSSTLWI 298

  Fly    71 -FNETQGILDRIEGHQEVNDKQLK------------------ALKVKMEGHFMDLHAKMEIKVKK 116
             .|:    ||...|.|..::..||                  .::.:..|.:.:...       .
Human   299 GLND----LDTSGGWQWSDNSPLKYLNWESDQPDNPSEENCGVIRTESSGGWQNRDC-------S 352

  Fly   117 LSLEKSLRKALNA-LQCSLDTRNVSSKVSLHPEFEKVGSRFFYIERHVKQNWFDAMTKCREMGGH 180
            ::|....:|..|| .:.:...|..:.||...|.::......:.::.. |::|.::...|...||.
Human   353 IALPYVCKKKPNATAEPTPPDRWANVKVECEPSWQPFQGHCYRLQAE-KRSWQESKKACLRGGGD 416

  Fly   181 LASPQNEEELHLISQ--KLDTESYWLDLSDLTDHGQYISLVSGSKAPFLKWNKGQPN--RENAQ- 240
            |.|..:..||..|::  |.:.|..|:.|:||.....: ....||...|..|:..:||  |::.:
Human   417 LVSIHSMAELEFITKQIKQEVEELWIGLNDLKLQMNF-EWSDGSLVSFTHWHPFEPNNFRDSLED 480

  Fly   241 CVRVKG--GLYQTFQCDHRVLFIC----QANQNRKKED 272
            ||.:.|  |.:....|:..:..||    |.:|...:||
Human   481 CVTIWGPEGRWNDSPCNQSLPSICKKAGQLSQGAAEED 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2839	NP_608540.1	CLECT	147..263	CDD:214480	31/126 (25%)
MRC2	NP_006030.2	RICIN	43..>127	CDD:238092
		RICIN	46..161	CDD:214672
		FN2	180..228	CDD:128373
		CLECT	247..361	CDD:153057	21/125 (17%)
		CLECT	382..505	CDD:214480	30/124 (24%)
		CLECT	521..644	CDD:214480
		CLECT	669..809	CDD:214480
		CLECT	829..951	CDD:214480
		CLECT	972..1108	CDD:214480
		CLECT	1137..1245	CDD:153057
		CLECT	1261..1394	CDD:214480
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1450..1479
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910