DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG2839 and Nefh

DIOPT Version :9

Sequence 1:NP_608540.1 Gene:CG2839 / 33244 FlyBaseID:FBgn0031273 Length:826 Species:Drosophila melanogaster
Sequence 2:NP_035034.2 Gene:Nefh / 380684 MGIID:97309 Length:1090 Species:Mus musculus


Alignment Length:882 Identity:190/882 - (21%)
Similarity:331/882 - (37%) Gaps:176/882 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 DRLKKLGEMCLIDILPILENISEQQKEGYTANFRIFNET--QGILDRIEGHQEVNDKQLKALKVK 98
            |.||     |  |:...|..| ..|.||:.....:.:|.  :..|||:....:||...:::.:.:
Mouse   259 DALK-----C--DVTSALREI-RAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEE 315

  Fly    99 MEGHFMDLHAKMEIKVKKLSLEKSLRKALNALQCSLDTRNVSSKVSLHPEFEKVGSRFFYIERHV 163
            :    .:...:::.:..:|...||.:::|...:..|:.|:.:...|.....:::.|..    |:.
Mouse   316 I----TEYRRQLQARTTELEALKSTKESLERQRSELEDRHQADIASYQDAIQQLDSEL----RNT 372

  Fly   164 KQNWFDAMTKCREMGGHLASPQNEEELHLISQKLDTESYWLDLSDLTDHGQYISLVSGSK----- 223
            |  |        ||...|   :..::|..:...||.|.           ..|..|:.|.:     
Mouse   373 K--W--------EMAAQL---REYQDLLNVKMALDIEI-----------AAYRKLLEGEECRIGF 413

  Fly   224 --APFLKWNKGQPNRENAQC-VRVKG-GLYQTFQCDHRVLFICQANQNRKK------EDEINKNQ 278
              :|| ...:|.|...:... ::||. .:.:..:...:...|.:......:      |:|..:.|
Mouse   414 GPSPF-SLTEGLPKIPSISTHIKVKSEEMIKVVEKSEKETVIVEGQTEEIRVTEGVTEEEDKEAQ 477

  Fly   279 GKPRIMEKERSKEEEKRKEEE--------------------RRREEERKREEERKREEERKREEE 323
            |:    |.|.::|.|:::|||                    .|.:||.|...|.|...|.|...|
Mouse   478 GQ----EGEEAEEGEEKEEEEGAAATSPPAEEAASPEKETKSRVKEEAKSPGEAKSPGEAKSPAE 538

  Fly   324 RKREEERKREEERRKEEERKKEEEREREEERKREHNRKKEEERKRE-------EKRRKEEEKRKE 381
            .|...|.|...|.:...|.|...|.:...|.|.....|...|.|..       |.:...|.|...
Mouse   539 AKSPGEAKSPGEAKSPGEAKSPAEPKSPAEPKSPAEAKSPAEPKSPATVKSPGEAKSPSEAKSPA 603

  Fly   382 EERRKEEERKEEERRKEEERKEEERRKEEERRK---------EKRRRDEKRRREEEKRKEEERKE 437
            |.:...|.:...|.:...|.|.....|.....|         |.:...|.:...|.|...|.:..
Mouse   604 EAKSPAEAKSPAEAKSPAEAKSPAEAKSPAEAKSPATVKSPGEAKSPSEAKSPAEAKSPAEAKSP 668

  Fly   438 EERREEAERK---EEERKAEERRKKEERRREEKRRREEKRRREE--------------------- 478
            .|.:..||.|   |.:..||.:...|.:...|.:...|.:...|                     
Mouse   669 AEAKSPAEVKSPGEAKSPAEPKSPAEAKSPAEVKSPAEAKSPAEVKSPGEAKSPAAVKSPAEAKS 733

  Fly   479 --------------------EERRKEEERREEEEKRKEEERRKDEERRREEEKRKEEERRE---K 520
                                |.:...|.:...|.|..|:.:...:|..:...:.|..|:.:   |
Mouse   734 PAAVKSPGEAKSPGEAKSPAEAKSPAEAKSPIEVKSPEKAKTPVKEGAKSPAEAKSPEKAKSPVK 798

  Fly   521 ERRREEGKRKEEERRE---KERRREEEKRKEEERREKERR---DEERR-----REEERRREEERR 574
            |..:...:.|..|:.:   ||..:..||.|..:.:..|.:   .||.:     |..|:.:...:.
Mouse   799 EDIKPPAEAKSPEKAKSPVKEGAKPPEKAKPLDVKSPEAQTPVQEEAKHPTDIRPPEQVKSPAKE 863

  Fly   575 REEERRREEERRREEERRREEERK---REEERRREEERRREEER-----RREEERRREEEKRKEE 631
            :.:...:||.:..|:...::||.|   :||.:.:|..::.|||:     :.|.:..:::|..||.
Mouse   864 KAKSPEKEEAKTSEKVAPKKEEVKSPVKEEVKAKEPPKKVEEEKTLPTPKTEAKESKKDEAPKEA 928

  Fly   632 ERRKEEERKR---EEEKRKEEERKREEERRREEEKRKEEERRKE---EERKREEEKRKEEKRKRE 690
            .:.|.||:|.   |:.|....|.|:||...:::....|||...:   :|..:.:||.:..|.:.|
Mouse   929 PKPKVEEKKETPTEKPKDSTAEAKKEEAGEKKKAVASEEETPAKLGVKEEAKPKEKTETTKTEAE 993

  Fly   691 EEKRKKEERKREEEKRKEDERKREEEKRKEEEKRKEEERKEEERKKKETEEKEKNMQEKCWVTKK 755
            :.|.|:..:..|.||.|::|.....||:..:|::..|.||.||:.|.|.:.||.:.......:|.
Mouse   994 DTKAKEPSKPTETEKPKKEEMPAAPEKKDTKEEKTTESRKPEEKPKMEAKVKEDDKSLSKEPSKP 1058

  Fly   756 GTNKC-KTCSTNEKGKKKCEVCWIRKDGEKKCKKSKK 791
            .|.|. |:.||::|..:..|     |..|.|..|.:|
Mouse  1059 KTEKAEKSSSTDQKESQPPE-----KTTEDKATKGEK 1090

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2839NP_608540.1 CLECT 147..263 CDD:214480 21/124 (17%)
NefhNP_035034.2 Head 2..98
Filament 94..410 CDD:278467 37/190 (19%)
Coil 1A 99..130
Linker 1 131..143
Coil 1B 144..242
Linker 12 243..264 4/11 (36%)
Coil 2A 265..286 5/21 (24%)
Linker 2 287..290 1/2 (50%)
Coil 2B 291..411 26/151 (17%)
Tail 412..1090 152/687 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 456..1090 145/642 (23%)
52 X 6 AA approximate tandem repeats of K-S-P-[AGISV]-[EATK]-[APVQ] 522..892 72/369 (20%)
MARCKS 529..819 CDD:280269 53/289 (18%)
DUF1388 531..557 CDD:284540 7/25 (28%)
DUF1388 603..629 CDD:284540 5/25 (20%)
DUF1388 663..688 CDD:284540 6/24 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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