DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lectin-21Cb and Clec4a

DIOPT Version :9

Sequence 1:	NP_608539.2	Gene:	lectin-21Cb / 33242	FlyBaseID:	FBgn0040106	Length:	249	Species:	Drosophila melanogaster
Sequence 2:	NP_001005899.2	Gene:	Clec4a / 474143	RGDID:	1359662	Length:	240	Species:	Rattus norvegicus

Alignment Length:	257	Identity:	53/257 - (20%)
Similarity:	84/257 - (32%)	Gaps:	86/257 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PKVSLSERLEKRGEFSLVEFDPLL------------KFIVK-NPHKELLGEIEGLVGHTENKLQP 77
            |:...:..|.|.|.. ||.|..|:            .||:. ..:.:.|.|.:.:.|.|..:|..
  Rat    29 PREKPTRHLSKPGSL-LVPFTSLMVLLLLLAITFLVAFIIYFQKYSQFLEEKKAIKGITHKELNC 92

  Fly    78 MKSVIPNQSKALLNYLDLHSKLEYLDAALQKAINSLQCSLKNTKVMSTGKPHPEFQKLGSRYFYI 142
            :|:|:..:.|                        |..|..||.|            ..||..:::
  Rat    93 IKNVLLMEEK------------------------SWSCCPKNWK------------PFGSHCYWV 121

  Fly   143 ERHV----RQNWFDAADKCRRMGGHLATPQDEDELYLIRKQL--------------EARWFWLDI 189
            .:|.    :.:|.::...|..||.||.....::|...|...|              ..:|.|
  Rat   122 TKHTSTYSKASWNESEKNCFSMGAHLLVIHSKEEQDFITGILNRDAAYFIGLWDSGHRQWQW--- 183

  Fly   190 SNLVDKDQYISLATGKEVSYLKWRHGEPKKSSTANCA---YLYAG-DYYTYQCSDRNFFICQ 247
               |.:..|.:.||       .|..||| .|....|.   :|.:| .:....||.:...:||
  Rat   184 ---VSQTPYNASAT-------FWHKGEP-SSDDEKCVIINHLNSGWGWNDIPCSGKQQSVCQ 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lectin-21Cb	NP_608539.2	CLECT	137..247	CDD:153057	27/131 (21%)
Clec4a	NP_001005899.2	ITIM motif	5..10
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..38		1/8 (13%)
		CLECT_DC-SIGN_like	107..235	CDD:153060	33/154 (21%)
		Mannose binding. /evidence=ECO:0000250\|UniProtKB:Q9UMR7	200..202		2/2 (100%)
		N-acetyl-D-glucosamine binding. /evidence=ECO:0000250\|UniProtKB:Q9UMR7	211..213		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010