DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lectin-21Cb and CD209

DIOPT Version :9

Sequence 1:	NP_608539.2	Gene:	lectin-21Cb / 33242	FlyBaseID:	FBgn0040106	Length:	249	Species:	Drosophila melanogaster
Sequence 2:	NP_066978.1	Gene:	CD209 / 30835	HGNCID:	1641	Length:	404	Species:	Homo sapiens

Alignment Length:	255	Identity:	54/255 - (21%)
Similarity:	93/255 - (36%)	Gaps:	75/255 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 QENNCPKVSLSERLEKRGEFSLVEFDPLLKFIV-----KNPHKELLGEIEGLVGHTENKLQPMKS 80
            ||....|.::.|..||..:..:.:....||..|     |:..:|:..|:        .:|:....
Human   171 QELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQEL--------TRLKAAVG 227

  Fly    81 VIPNQSKALLNYLDLHSKLEYLDAALQKAINSLQCSLKNTKVMSTGKPHP------EFQKLGSRY 139
            .:|.:||    ..:::.:|..|.||:::.     |             ||      .||  |:.|
Human   228 ELPEKSK----QQEIYQELTQLKAAVERL-----C-------------HPCPWEWTFFQ--GNCY 268

  Fly   140 FYIERHVRQNWFDAADKCRRMGGHLATPQDEDELYLIRKQ----------------LEARWFWLD 188
            |.  .:.::||.|:...|:.:|..|...:..:|...::.|                .|..|.|:|
Human   269 FM--SNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVD 331

  Fly   189 ISNLVDK-DQYISLATGKEVSYLKWRHGEPKKSSTANCAYLYAGDYYTYQCSDRNFFICQ 247
            .|.|:.. .||             |..|||......:||......:...:|:...|:||:
Human   332 GSPLLPSFKQY-------------WNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICK 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lectin-21Cb	NP_608539.2	CLECT	137..247	CDD:153057	27/126 (21%)
CD209	NP_066978.1	Endocytosis signal	14..15
		Endocytosis signal. /evidence=ECO:0000255	16..18
		Endocytosis signal. /evidence=ECO:0000255	31..34
		transmembrane domain	36..59
		PilO	38..>184	CDD:294757	4/12 (33%)
		neck domain	60..249		19/89 (21%)
		CLECT_DC-SIGN_like	256..379	CDD:153060	31/140 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010