DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lectin-21Cb and CLEC4M

DIOPT Version :9

Sequence 1:	NP_608539.2	Gene:	lectin-21Cb / 33242	FlyBaseID:	FBgn0040106	Length:	249	Species:	Drosophila melanogaster
Sequence 2:	NP_055072.3	Gene:	CLEC4M / 10332	HGNCID:	13523	Length:	399	Species:	Homo sapiens

Alignment Length:	231	Identity:	53/231 - (22%)
Similarity:	94/231 - (40%)	Gaps:	52/231 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PHKELLGEI-------EGLVGH--TENKLQPMKSVIPNQSKALLNYLDLHSKLE--YLD-AALQK 108
            |.|..|.||       :..||.  .::|||.:...: .:.||.:..|...|||:  |.: ..|:.
Human   173 PEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQEL-TELKAAVGELPEKSKLQEIYQELTQLKA 236

  Fly   109 AINSLQCSLKNTKV------MSTGKPHPEFQKL------------GSRYFYIERHVRQNWFDAAD 155
            |:..|....|..::      :.|.     |::|            |:.||.  .:.::||.|:..
Human   237 AVGELPDQSKQQQIYQELTDLKTA-----FERLCRHCPKDWTFFQGNCYFM--SNSQRNWHDSVT 294

  Fly   156 KCRRMGGHLATPQDEDELYLIRKQLEA--RWFWLDISNLVDKD--QYISLATGKEVS-----YLK 211
            .|:.:...|...:..:|...::.|...  |:.|:.:|:|..:.  |::.   |..:|     |
Human   295 ACQEVRAQLVVIKTAEEQNFLQLQTSRSNRFSWMGLSDLNQEGTWQWVD---GSPLSPSFQRY-- 354

  Fly   212 WRHGEPKKSSTANCAYLYAGDYYTYQCSDRNFFICQ 247
            |..|||..|...:||......:...:|...|::||:
Human   355 WNSGEPNNSGNEDCAEFSGSGWNDNRCDVDNYWICK 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lectin-21Cb	NP_608539.2	CLECT	137..247	CDD:153057	27/118 (23%)
CLEC4M	NP_055072.3	Endocytosis signal. /evidence=ECO:0000250	14..15
		transmembrane domain	44..71
		7 X approximate tandem repeats	108..269		24/101 (24%)
		DUF342	<140..251	CDD:302792	21/78 (27%)
		CLECT_DC-SIGN_like	268..391	CDD:153060	29/130 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010