DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gsc and PDLIM7

DIOPT Version :9

Sequence 1:NP_001137762.2 Gene:Gsc / 33240 FlyBaseID:FBgn0010323 Length:473 Species:Drosophila melanogaster
Sequence 2:NP_005442.2 Gene:PDLIM7 / 9260 HGNCID:22958 Length:457 Species:Homo sapiens


Alignment Length:331 Identity:65/331 - (19%)
Similarity:101/331 - (30%) Gaps:120/331 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 PAGYTLKRSPSDLGEQQQPPRQISR-SPGNTAAYHLTT----AMLLNSQQCGYL----------- 114
            |.|:.|:.     |:....|..||| :||..||.....    .:.::.:..|.|           
Human    13 PWGFRLQG-----GKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLTHIEAQNKIRA 72

  Fly   115 -GQRLQSVLQQ-QHAQHQQSQSQTPSSDDGSQS---GVTILEEERRGGAAAASLFTIDSILGSRQ 174
             |:||...|.: |..|.:..::..|::|....:   .|::.:..|..||...:    ||   :.|
Human    73 CGERLSLGLSRAQPVQSKPQKASAPAADPPRYTFAPSVSLNKTARPFGAPPPA----DS---APQ 130

  Fly   175 QGG--------------------------GTAPSQ---------GSHISSNGNQNGLTSNGISLG 204
            |.|                          ||..|:         |:....:.::..|..   |..
Human   131 QNGQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKK---SSQ 192

  Fly   205 LKRSGAESPASPNSNSSSSAAASPIRPQRVPAMLQHPGLHLGHLAAAAASGFAASPSDFLVAYPN 269
            :.|:.|.:|||...........:|....|.|                    :|..|     |:..
Human   193 VPRTEAPAPASSTPQEPWPGPTAPSPTSRPP--------------------WAVDP-----AFAE 232

  Fly   270 FY-PNYMHAAAVAHVAAAQ----------MQAHVSGAAAGLSGHGHHP--HHPH----------- 310
            .| |:........|...|.          :||...|...|.|.:|..|  |..|           
Human   233 RYAPDKTSTVLTRHSQPATPTPLQSRTSIVQAAAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVAL 297

  Fly   311 GHPHHP 316
            ||.:||
Human   298 GHAYHP 303

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GscNP_001137762.2 Homeobox 343..396 CDD:278475
PDLIM7NP_005442.2 PDZ_signaling 5..79 CDD:238492 17/70 (24%)
Atrophin-1 <81..254 CDD:331285 35/207 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 82..142 13/66 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 176..226 10/72 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 239..258 2/18 (11%)
LIM1_Enigma 282..333 CDD:188836 6/22 (27%)
LIM2_Enigma 341..392 CDD:188840
LIM3_Enigma 400..454 CDD:188842
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R6207
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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