Protein Alignment Gsc and RHOXF2B

DIOPT Version :10

• Sequence 1: NP_001137762.2
• Gene: Gsc / 33240
• FlyBaseID: FBgn0010323
• Length: 473
• Species: Drosophila melanogaster
• Sequence 2: NP_001093155.1
• Gene: RHOXF2B / 727940
• HGNCID: 33519
• Length: 288
• Species: Homo sapiens
• Alignment Length: 327
• Identity: 59/327 - (18%)
• Similarity: 103/327 - (31%)
• Gaps: 143/327 - (43%)

  Fly    83 QPPRQISRSPGNTAAYHLTTAM---LLNSQQCGYLGQRLQSVLQQQHAQHQQSQSQTPSSDDGSQ 144
            :||.|.|:        ::|:.:   :.:.::...:...:.|:.::...:.:.:|   |..:.|:.
Human     2 EPPDQCSQ--------YMTSLLSPAVDDEKELQDMNAMVLSLTEEVKEEEEDAQ---PEPEQGTA 55

  Fly   145 SGVTILE------EERRGGAAAASLFTIDSILGSRQQGGGTAPSQGSHISSNGNQNGLTSNGISL 203
            :|..:..      ||:.||             |..:.|||....  .|: ..||..|
Human    56 AGEKLKSAGAQGGEEKDGG-------------GEEKDGGGAGVP--GHL-WEGNLEG-------- 96

  Fly   204 GLKRSGAESPASPNSNSSSSAAASPIRPQRVPAMLQHPGLHLGHLAAAAASGFAASPSDFLVAYP 268
               .||::.....:..|.........|||
Human    97 ---TSGSDGNVEDSDQSEKEPGQQYSRPQ------------------------------------ 122

  Fly   269 NFYPNYMHAAAVAHVAAAQMQAHVSGAAAGLSGHGHHPHHPHGHPHHPHLGAHHHGQHHLSHLGH 333
                                     ||..||.         .|:...|::.|
Human   123 -------------------------GAVGGLE---------PGNAQQPNVHA------------- 140

  Fly   334 GPPPKRKRRHRTIFTEEQLEQLEATFDKTHYPDVVLREQLALKVDLKEERVEVWFKNRRAKWRKQ 398
                         ||..||::||..|.:..:|...||.:||..:::.|..|::||:|||||||:.
Human   141 -------------FTPLQLQELECIFQREQFPSEFLRRRLARSMNVTELAVQIWFENRRAKWRRH 192

  Fly   399 KR 400
            :|
Human   193 QR 194

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gsc	NP_001137762.2	Homeodomain	341..397	CDD:459649	22/55 (40%)
RHOXF2B	NP_001093155.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..136		28/219 (13%)
		Homeodomain	139..191	CDD:459649	23/77 (30%)
		PRK02287	<183..>232	CDD:235024	8/12 (67%)
		Nuclear localization signal. /evidence=ECO:0000250	186..195		6/9 (67%)