Protein Alignment Gsc and SHOX2

DIOPT Version :10

• Sequence 1: NP_001137762.2
• Gene: Gsc / 33240
• FlyBaseID: FBgn0010323
• Length: 473
• Species: Drosophila melanogaster
• Sequence 2: NP_003021.3
• Gene: SHOX2 / 6474
• HGNCID: 10854
• Length: 355
• Species: Homo sapiens
• Alignment Length: 239
• Identity: 64/239 - (26%)
• Similarity: 85/239 - (35%)
• Gaps: 80/239 - (33%)

  Fly   173 RQQGGGTAPSQGSHISSNGNQNGLTSNGISLG----------LKRSGAESPASPNSNSSSSAAAS 227
            |..|||.....|.  ...|...|:...|...|          |....||....|.|...:.....
Human    57 RAAGGGGGGGGGG--GGGGGGGGVGGGGAGGGAGGGRSPVRELDMGAAERSREPGSPRLTEGRRK 119

  Fly   228 PIRPQRVPAMLQHPGLHLGHLAAAAASGFAASPSDFLVAYPNFYPNYMHAAAVAHVAAAQMQAHV 292
            |.:.: |.|.|..||         .|..|..||                          :::...
Human   120 PTKAE-VQATLLLPG---------EAFRFLVSP--------------------------ELKDRK 148

  Fly   293 SGAAAGLSGHGHHPHHPHGHPHHPHLGAHHHGQHHLSHLGHGPPPKRKRRHRTIFTEEQLEQLEA 357
            ..|.                      |....||..:          ::||.||.||.|||.:||.
Human   149 EDAK----------------------GMEDEGQTKI----------KQRRSRTNFTLEQLNELER 181

  Fly   358 TFDKTHYPDVVLREQLALKVDLKEERVEVWFKNRRAKWRKQKRE 401
            .||:|||||..:||:|:.::.|.|.||:|||:|||||.|||:.:
Human   182 LFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQ 225

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gsc	NP_001137762.2	Homeodomain	341..397	CDD:459649	33/55 (60%)
SHOX2	NP_003021.3	Homeodomain	165..221	CDD:459649	33/55 (60%)
		OAR	335..351	CDD:461067