Protein Alignment Gsc and OTX2

DIOPT Version :10

• Sequence 1: NP_001137762.2
• Gene: Gsc / 33240
• FlyBaseID: FBgn0010323
• Length: 473
• Species: Drosophila melanogaster
• Sequence 2: NP_068374.1
• Gene: OTX2 / 5015
• HGNCID: 8522
• Length: 297
• Species: Homo sapiens
• Alignment Length: 165
• Identity: 56/165 - (33%)
• Similarity: 90/165 - (54%)
• Gaps: 40/165 - (24%)

  Fly   315 HPHLGAHHHGQHHLSHLGHGP-------PPKRKRRHRTIFTEEQLEQLEATFDKTHYPDVVLREQ 372
            ||.:|.            .||       .|:::||.||.||..||:.|||.|.||.|||:.:||:
Human    26 HPSVGY------------PGPWASCPAATPRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREE 78

  Fly   373 LALKVDLKEERVEVWFKNRRAKWRKQKREE----QERLRKLQEEQCG----STTNGTT------N 423
            :|||::|.|.||:|||||||||.|:|::::    |.::|..:::...    |:.:||:      :
Human    79 VALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKTSPAREVSSESGTSGQFTPPS 143

  Fly   424 SSSGTTSSTGNGSLTVKCPGSDHYSAQLVHIKSDP 458
            |:|..|.::.:..:::..|.|       :...|||
Human   144 STSVPTIASSSAPVSIWSPAS-------ISPLSDP 171

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gsc	NP_001137762.2	Homeodomain	341..397	CDD:459649	35/55 (64%)
OTX2	NP_068374.1	Homeodomain	47..102	CDD:459649	35/54 (65%)
		TF_Otx	161..242	CDD:427350	5/18 (28%)