DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gsc and pitx3

DIOPT Version :9

Sequence 1:	NP_001137762.2	Gene:	Gsc / 33240	FlyBaseID:	FBgn0010323	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	NP_991238.1	Gene:	pitx3 / 402974	ZFINID:	ZDB-GENE-041229-4	Length:	293	Species:	Danio rerio

Alignment Length:	149	Identity:	56/149 - (37%)
Similarity:	74/149 - (49%)	Gaps:	12/149 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 GHPHH-PHLGAHHHGQHHLSHLGH--------GPPPKRKRRHRTIFTEEQLEQLEATFDKTHYPD 366
            |.|.| |......:.....||..|        |...|::||.||.||.:||::|||||.:..|||
Zfish    22 GTPQHDPGCKGQDNSDTEKSHQNHTDESNPEDGSLKKKQRRQRTHFTSQQLQELEATFQRNRYPD 86

  Fly   367 VVLREQLALKVDLKEERVEVWFKNRRAKWRKQKREEQERLRKLQEEQCGSTTNGTTNSSSGTTSS 431
            :..||::|:..:|.|.||.||||||||||||::|.:|..|.|   ...|:..||.........|.
Zfish    87 MSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCK---NGFGAQFNGLMQPYDDMYSG 148

  Fly   432 TGNGSLTVKCPGSDHYSAQ 450
            ....:...|...|...||:
Zfish   149 YSYNNWATKSLASSPLSAK 167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gsc	NP_001137762.2	Homeobox	343..396	CDD:278475	30/52 (58%)
pitx3	NP_991238.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..69		14/46 (30%)
		Cnd2	18..>79	CDD:303063	20/56 (36%)
		Homeobox	64..116	CDD:278475	30/51 (59%)
		OAR	251..268	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	255..268
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O35160	260..264
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940