Protein Alignment Gsc and VSX2

DIOPT Version :10

• Sequence 1: NP_001137762.2
• Gene: Gsc / 33240
• FlyBaseID: FBgn0010323
• Length: 473
• Species: Drosophila melanogaster
• Sequence 2: NP_878314.1
• Gene: VSX2 / 338917
• HGNCID: 1975
• Length: 361
• Species: Homo sapiens
• Alignment Length: 260
• Identity: 78/260 - (30%)
• Similarity: 105/260 - (40%)
• Gaps: 70/260 - (26%)

  Fly   157 GAAAASLFTIDSILGSRQQGGGTAPSQGSHISSNGNQNGLTSNGIS--LGLKRSGAESPASPNSN 219
            |.|..:|....|...::...|| ||::            .|..||.  |||.:   |.|:|
Human     3 GKAGEALSKPKSETVAKSTSGG-APAR------------CTGFGIQEILGLNK---EPPSS---- 47

  Fly   220 SSSSAAASPIRPQRVPAMLQHP-----GLHLGHLAAAAASGFAASPSDFLVAYPNFYPNYMHAAA 279
                                ||     ||..|||.||.:....|......:..|...|.:.....
Human    48 --------------------HPRAALDGLAPGHLLAARSVLSPAGVGGMGLLGPGGLPGFYTQPT 92

  Fly   280 VAHVAAAQMQAHVS--GAAAGLSGHGHHPHHPHGHPHHPHLGAHHHGQ------HHLSHLGHGPP 336
            ...|.:.....|:.  |.|:|              |......|....:      ..:|.......
Human    93 FLEVLSDPQSVHLQPLGRASG--------------PLDTSQTASSDSEDVSSSDRKMSKSALNQT 143

  Fly   337 PKR-KRRHRTIFTEEQLEQLEATFDKTHYPDVVLREQLALKVDLKEERVEVWFKNRRAKWRKQKR 400
            .|| |||||||||..|||:||..|::.|||||..||.||:|.:|.|:|::|||:||||||||:::
Human   144 KKRKKRRHRTIFTSYQLEELEKAFNEAHYPDVYAREMLAMKTELPEDRIQVWFQNRRAKWRKREK 208

  Fly   401  400
            Human   209  208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gsc	NP_001137762.2	Homeodomain	341..397	CDD:459649	36/55 (65%)
VSX2	NP_878314.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		8/25 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	104..151		11/60 (18%)
		Homeodomain	153..205	CDD:459649	32/51 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..300
		OAR	300..318	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	304..317
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..361