Protein Alignment Gsc and RAX

DIOPT Version :10

• Sequence 1: NP_001137762.2
• Gene: Gsc / 33240
• FlyBaseID: FBgn0010323
• Length: 473
• Species: Drosophila melanogaster
• Sequence 2: NP_038463.2
• Gene: RAX / 30062
• HGNCID: 18662
• Length: 346
• Species: Homo sapiens
• Alignment Length: 319
• Identity: 89/319 - (27%)
• Similarity: 123/319 - (38%)
• Gaps: 107/319 - (33%)

  Fly   137 PSSDDGSQS--GVTILEEERRGGAAAASLFTIDSILGSRQQGG--GTAPSQGSHISSNGNQNGLT 197
            |:..|||.|  |..:    |..|.:.:.|.:|::|||..:..|  ||.|::..
Human     8 PAMADGSFSLAGHLL----RSPGGSTSRLHSIEAILGFTKDDGILGTFPAERG------------ 56

  Fly   198 SNGISLGLKRSGAESPASPNSNSSSSAAASPIRPQRVPA-------MLQHPGLHLGHLAAAAASG 255
            :.|.....:|.||. ||.|.:....|..:.|..|...|.       ..:.||      .|..:.|
Human    57 ARGAKERDRRLGAR-PACPKAPEEGSEPSPPPAPAPAPEYEAPRPYCPKEPG------EARPSPG 114

  Fly   256 FAASPSDFLVAYPNFYPNYMHAAAVAHVAAAQMQAHVSGAAAGLSGHGHHPHHPHGHPHHPHLGA 320
            ....|:.
Human   115 LPVGPAT---------------------------------------------------------- 121

  Fly   321 HHHGQHHLSHLGHGPPPKRKRRHRTIFTEEQLEQLEATFDKTHYPDVVLREQLALKVDLKEERVE 385
               |:..||.  ...|.|:.||:||.||..||.:||..|:|:|||||..||:||.||:|.|.||:
Human   122 ---GEAKLSE--EEQPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRVQ 181

  Fly   386 VWFKNRRAKWRKQKREEQERLRKLQEEQCGSTTNGTTNSSSGTTSSTGNGSLTVKCPGS 444
            |||:|||||||:|::.|...: |||:....|.:.   :..|.|.|..|.|      |||
Human   182 VWFQNRRAKWRRQEKLEVSSM-KLQDSPLLSFSR---SPPSATLSPLGAG------PGS 230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gsc	NP_001137762.2	Homeodomain	341..397	CDD:459649	36/55 (65%)
RAX	NP_038463.2	Octapeptide motif	33..40		2/6 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	46..145		30/180 (17%)
		Homeodomain	137..193	CDD:459649	36/55 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..318		14/47 (30%)
		OAR	319..335	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	323..336
		Nuclear localization signal. /evidence=ECO:0000255	329..333