Protein Alignment Gsc and GSC2

DIOPT Version :10

• Sequence 1: NP_001137762.2
• Gene: Gsc / 33240
• FlyBaseID: FBgn0010323
• Length: 473
• Species: Drosophila melanogaster
• Sequence 2: NP_005306.1
• Gene: GSC2 / 2928
• HGNCID: 4613
• Length: 205
• Species: Homo sapiens
• Alignment Length: 256
• Identity: 80/256 - (31%)
• Similarity: 103/256 - (40%)
• Gaps: 86/256 - (33%)

  Fly   156 GGAAAASLFTIDSILGSRQQGGGTAPSQGSHISSNGNQNGLTSNGISLGLKRSGAESPASPNSNS 220
            ||||            ||:..|...|....||.|:..:..|.:.. :...:.:|.:|||.|....
Human     6 GGAA------------SRRGAGRPCPFSIEHILSSLPERSLPARA-ACPPQPAGRQSPAKPEEPG 57

  Fly   221 SSSAA-----------ASPIRPQRVPAMLQHPGLHLGHLAAAAASGFAASPSDFLVAYPNFYPNY 274
            :..||           |:|..|..                  ||:|..|..:         :|..
Human    58 APEAAPCACCCCCGPRAAPCGPPE------------------AAAGLGARLA---------WPLR 95

  Fly   275 MHAAAVAHVAAAQMQAHVSGAAAGLSGHGHHPHHPHGHPHHPHLGAHHHGQHHLSHLGHGPPPKR 339
            :..|....:.|   .|..|||..|..|.|..                                :|
Human    96 LGPAVPLSLGA---PAGGSGALPGAVGPGSQ--------------------------------RR 125

  Fly   340 KRRHRTIFTEEQLEQLEATFDKTHYPDVVLREQLALKVDLKEERVEVWFKNRRAKWRKQKR 400
            .|||||||:||||:.|||.|.:..||||..||:||.::.|:||||||||||||||||.|||
Human   126 TRRHRTIFSEEQLQALEALFVQNQYPDVSTRERLAGRIRLREERVEVWFKNRRAKWRHQKR 186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gsc	NP_001137762.2	Homeodomain	341..397	CDD:459649	39/55 (71%)
GSC2	NP_005306.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	33..58		6/25 (24%)
		Homeodomain	127..183	CDD:459649	39/55 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	185..205		2/2 (100%)