DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gsc and PDLIM3

DIOPT Version :9

Sequence 1:	NP_001137762.2	Gene:	Gsc / 33240	FlyBaseID:	FBgn0010323	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	NP_055291.2	Gene:	PDLIM3 / 27295	HGNCID:	20767	Length:	364	Species:	Homo sapiens

Alignment Length:	236	Identity:	46/236 - (19%)
Similarity:	78/236 - (33%)	Gaps:	91/236 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PTPPPAGSMLAQMVETNSPPAGYTLKRSPSDLGEQQQPPRQISR-SPGN-TAAYHL--------- 100
            |.|.|.|..|:..::.|.|..                    |:| :||: .||.:|
Human     8 PGPAPWGFRLSGGIDFNQPLV--------------------ITRITPGSKAAAANLCPGDVILAI 52

  Fly   101 ----TTAMLLNSQQCGYLGQRLQSVLQQQHAQHQQSQSQTPS---SDDGSQSGVTI-LEEERRGG 157
                |.:|.....|     .|:::...|...:..:.::...|   |:||......| ||.|
Human    53 DGFGTESMTHADAQ-----DRIKAAAHQLCLKIDRGETHLWSPQVSEDGKAHPFKINLESE---- 108

  Fly   158 AAAASLFTIDSILGSRQQGGGTAPSQGSHISSN-----------GNQNGL-TSNGISLGLKRSGA 210
                                   |..|::....           |..:|. |.:||..|   ||.
Human   109 -----------------------PQDGNYFEHKHNIRPKPFVIPGRSSGCSTPSGIDCG---SGR 147

  Fly   211 ESPASPNSNSS----SSAAASPIRPQRVPAMLQHPGLHLGH 247
            .:|:|.::.|:    ....|:.:.| .:|..::.||:.:.|
Human   148 STPSSVSTVSTICPGDLKVAAKLAP-NIPLEMELPGVKIVH 187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gsc	NP_001137762.2	Homeobox	343..396	CDD:278475
PDLIM3	NP_055291.2	PDZ_signaling	2..80	CDD:238492	19/96 (20%)
		DUF4749	184..263	CDD:374237	1/4 (25%)
		LIM_ALP	294..346	CDD:188834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030