DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gsc and alp-1

DIOPT Version :9

Sequence 1:	NP_001137762.2	Gene:	Gsc / 33240	FlyBaseID:	FBgn0010323	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	NP_001023371.1	Gene:	alp-1 / 177701	WormBaseID:	WBGene00001132	Length:	1424	Species:	Caenorhabditis elegans

Alignment Length:	514	Identity:	97/514 - (18%)
Similarity:	158/514 - (30%)	Gaps:	189/514 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TTTPSTTP---DIPPSKAKFKI--TVVSTP---SPSPPPTP-----PPAGSMLAQMVETNSPPAG 68
            |:.|...|   .:||.|....|  ||:.:|   ||||....     |.:..::..:....|.|.|
Worm   563 TSKPLEEPCPEALPPPKINDGIHWTVIHSPVLRSPSPAKVTSEAAIPESNGVVKPIPSYASQPIG 627

  Fly    69 YTLKRSPSDL--GEQ-QQP----------------PRQISRSPGNTAAY-------HLTTAMLLN 107
            .:...:|...  |.| ::|                ||....||....:|       ::||:
Worm   628 ISKTSTPQPFRPGSQVERPHYSSVGLKDVHAPVPLPRSPQHSPQPVQSYIVRSSDANVTTS---- 688

  Fly   108 SQQCGYLGQRLQSVLQQQHAQH----QQSQSQTPSSDDGSQSGVTILEEERRGGAAAASLFTIDS 168
                    ..||:.:.:|:.::    |..|...|.:.|.|.|.:..:...|.
Worm   689 --------TNLQTTVTRQYTENDNKSQFLQQPHPDTIDSSTSPIPTIRLNRH------------- 732

  Fly   169 ILGSRQQGGGTAPSQGSHIS-SNGNQNGLTSNGISLGLKRSGAESPASPNSNSSSSAAASPIR-- 230
                      |.|...:.:| ...:.|.:.::.|.:       ..|:.|...|.|::|.|||:
Worm   733 ----------TKPEPSTPLSVPTVSINDIATSPIKI-------TEPSRPWRASVSNSATSPIKIH 780

  Fly   231 PQRVPAMLQHPGLHLGHLAAAAASGFAASPSDFLVAYPNFYPNYMHAAAVAHVAAAQ-----MQA 290
            ..||..:.:..|||.....|...:      |...:..|:..|..:|.....:..||.     ||
Worm   781 ESRVQPVDESRGLHRHEEKAQIET------STIKIHEPSSPPPSVHKFGAVNTRAAPAPVQFMQ- 838

  Fly   291 HVSGAAAGLSGHGHHPHHPHGHPHHPHLGAHHHGQHHLSHLGHGPPPKRKRRH------------ 343
                 ...::...|.|..|  .|..|...:|              |.||..:|
Worm   839 -----TPRIAVKIHEPTGP--SPTPPSTPSH--------------PIKRDPKHFKKVDFSKTSPT 882

  Fly   344 --------------RTIFTEEQLEQLEATF--------DKTHYPD--VVLREQLALKVDLKEERV 384
                          ..|.||...|....:|        |::...|  :..:..:....|::||.|
Worm   883 VIPEWKDSADIVDESDILTECSREDDSISFLKAATYDGDESEMIDNNIDNKSDITSTFDIEEEEV 947

  Fly   385 EVWFKNRRAK---------------WRKQKRE-----------------EQERLRKLQE 411
            :|.....|.:               ||::..|                 ..|||:.|:|
Worm   948 DVVQDRERIRVVGRKGGEGGEAEKQWRQRAMELLDDDAQTERDLRIVAALNERLQGLRE 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gsc	NP_001137762.2	Homeobox	343..396	CDD:278475	14/103 (14%)
alp-1	NP_001023371.1	PDZ_signaling	5..80	CDD:238492
		DUF4749	137..>197	CDD:292558
		ZM	137..162	CDD:128974
		LIM_ALP_like	220..271	CDD:188746
		LIM1_Enigma_like_1	1251..1304	CDD:188839
		LIM	1312..1363	CDD:295319
		LIM3_Enigma_like_1	1371..1424	CDD:188845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030