DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pph13 and PHOX2B

DIOPT Version :9

Sequence 1:	NP_477330.1	Gene:	Pph13 / 33239	FlyBaseID:	FBgn0023489	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_003915.2	Gene:	PHOX2B / 8929	HGNCID:	9143	Length:	314	Species:	Homo sapiens

Alignment Length:	147	Identity:	67/147 - (45%)
Similarity:	81/147 - (55%)	Gaps:	27/147 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DKGTM--KRKQRRYRTTFNTLQLQELERAFQRTHYPDVFFREELAVRIDLTEARVQVWFQNRRAK 64
            |.|.:  ||||||.||||.:.||:||||.|..|||||::.|||||::||||||||||||||||||
Human    88 DHGGLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAK 152

  Fly    65 WRKQEKI---------GGLGGDYKEGALDLDVSYDDSAVLGQLD-SALGGGGTLLPDTPPQSSNS 119
            :||||:.         .|..|...:.:.|     |:|......| .:.||.|.....||...:|
Human   153 FRKQERAAAAAAAAAKNGSSGKKSDSSRD-----DESKEAKSTDPDSTGGPGPNPNPTPSCGAN- 211

  Fly   120 LDNELKASYGTGAMSPS 136
                     |.|...||
Human   212 ---------GGGGGGPS 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pph13	NP_477330.1	Homeobox	14..66	CDD:278475	39/51 (76%)
PHOX2B	NP_003915.2	Homeobox	102..155	CDD:395001	39/52 (75%)
PHOX2B	NP_003915.2	polyalanine repeat	241..260
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910