DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pph13 and ALX1

DIOPT Version :9

Sequence 1:	NP_477330.1	Gene:	Pph13 / 33239	FlyBaseID:	FBgn0023489	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_008913.2	Gene:	ALX1 / 8092	HGNCID:	1494	Length:	326	Species:	Homo sapiens

Alignment Length:	209	Identity:	74/209 - (35%)
Similarity:	101/209 - (48%)	Gaps:	43/209 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DKGTMKRKQRRYRTTFNTLQLQELERAFQRTHYPDVFFREELAVRIDLTEARVQVWFQNRRAKWR 66
            |......|:||:||||.:|||:|||:.||:||||||:.||:||:|.:||||||||||||||||||
Human   124 DSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWR 188

  Fly    67 KQEKIGGLGGDYKEGALDLDVSYDDSAVLGQLDSALGGGGTLLP--DTPPQSSNSL--DNELKAS 127
            |:|:.|.:.......|...|:|                   :||  |:.||..|:|  .|....|
Human   189 KRERYGQIQQAKSHFAATYDIS-------------------VLPRTDSYPQIQNNLWAGNASGGS 234

  Fly   128 YGTGAMSPSRLSPNIFLNLNIDHLGLERGGSGLSMEWSTYPPQTQAQTHPQMDSDNQLQQHPPQQ 192
            ..|..|.|                   |..|.....:| :.|:|.:......:..||....|...
Human   235 VVTSCMLP-------------------RDTSSCMTPYS-HSPRTDSSYTGFSNHQNQFSHVPLNN 279

  Fly   193 HASDPIHAGSSSHH 206
            ..:|.:..|:::.|
Human   280 FFTDSLLTGATNGH 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pph13	NP_477330.1	Homeobox	14..66	CDD:278475	39/51 (76%)
ALX1	NP_008913.2	Homeobox	135..189	CDD:365835	40/53 (75%)
		Transactivation domain. /evidence=ECO:0000250\|UniProtKB:Q63087	192..326		27/141 (19%)
		OAR	302..320	CDD:367680
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	306..319
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41860
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5874
SonicParanoid	1	1.000	-	-		X469
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.050