DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pph13 and ESX1

DIOPT Version :9

Sequence 1:	NP_477330.1	Gene:	Pph13 / 33239	FlyBaseID:	FBgn0023489	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_703149.1	Gene:	ESX1 / 80712	HGNCID:	14865	Length:	406	Species:	Homo sapiens

Alignment Length:	108	Identity:	48/108 - (44%)
Similarity:	61/108 - (56%)	Gaps:	13/108 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KRKQRRYRTTFNTLQLQELERAFQRTHYPDVFFREELAVRIDLTEARVQVWFQNRRAKWRKQEKI 71
            :||:|| ||.|...||||||..|..:.||||..||.||.|::|||.|||||||||||||::.:::
Human   137 ERKRRR-RTAFTQFQLQELENFFDESQYPDVVARERLAARLNLTEDRVQVWFQNRRAKWKRNQRV 200

  Fly    72 GGLGGDYKEGALDLDVSYDDSAVLGQLDSALGGGGTLLPDTPP 114
            ..|     ......|:::       .||..|||.....|...|
Human   201 LML-----RNTATADLAH-------PLDMFLGGAYYAAPALDP 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pph13	NP_477330.1	Homeobox	14..66	CDD:278475	34/51 (67%)
ESX1	NP_703149.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..142		2/4 (50%)
		Nuclear localization signal. /evidence=ECO:0000255	138..143		4/5 (80%)
		Homeobox	142..195	CDD:278475	35/53 (66%)
		15 X 9 AA tandem repeats of P-P-x-x-P-x-P-P-x	244..378
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..364
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.870