DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pph13 and ALX4

DIOPT Version :9

Sequence 1:	NP_477330.1	Gene:	Pph13 / 33239	FlyBaseID:	FBgn0023489	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_068745.2	Gene:	ALX4 / 60529	HGNCID:	450	Length:	411	Species:	Homo sapiens

Alignment Length:	185	Identity:	67/185 - (36%)
Similarity:	92/185 - (49%)	Gaps:	41/185 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DKGTMKRKQRRYRTTFNTLQLQELERAFQRTHYPDVFFREELAVRIDLTEARVQVWFQNRRAKWR 66
            |..:.|.|:||.||||.:.||:|||:.||:||||||:.||:||:|.|||||||||||||||||||
Human   206 DSESNKGKKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWR 270

  Fly    67 KQEKIGGLGGDYKEGALDLDVSYD-------DSAVLGQLDSALGGGGTLLP-------------- 110
            |:|:.|.:    ::.......:|:       ::....|..|.||..|...|
Human   271 KRERFGQM----QQVRTHFSTAYELPLLTRAENYAQIQNPSWLGNNGAASPVPACVVPCDPVPAC 331

  Fly   111 ----DTPPQSSNSLDNELKASYGTGAMSPSRLSPNIFLNLNIDHLGLERGGSGLS 161
                ..||.|..|...:..:..|.|:            ::...|:|...|.:.||
Human   332 MSPHAHPPGSGASSVTDFLSVSGAGS------------HVGQTHMGSLFGAASLS 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pph13	NP_477330.1	Homeobox	14..66	CDD:278475	39/51 (76%)
ALX4	NP_068745.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..145
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..219		5/12 (42%)
		Homeobox	218..270	CDD:278475	39/51 (76%)
		OAR	387..404	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	391..404
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41860
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X469
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020