Protein Alignment Pph13 and Pitx2

DIOPT Version :10

• Sequence 1: NP_477330.1
• Gene: Pph13 / 33239
• FlyBaseID: FBgn0023489
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_001035970.1
• Gene: Pitx2 / 54284
• RGDID: 3331
• Length: 324
• Species: Rattus norvegicus
• Alignment Length: 241
• Identity: 77/241 - (31%)
• Similarity: 111/241 - (46%)
• Gaps: 53/241 - (21%)

  Fly     2 DKG-------------TMKRKQRRYRTTFNTLQLQELERAFQRTHYPDVFFREELAVRIDLTEAR 53
            |||             :.|::|||.||.|.:.||||||..|||..|||:..|||:||..:|||||
  Rat    71 DKGQQGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEAR 135

  Fly    54 VQVWFQNRRAKWRKQEK--------------IGGLGGDYKEGALDLDVSYDDSAVLGQLDSALGG 104
            |:|||:||||||||:|:              ..||...|.:  :....||::.|..|...::|..
  Rat   136 VRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDD--MYPGYSYNNWAAKGLTSASLST 198

  Fly   105 GGTLLP-----DTPPQSSNSL---DNELKASYGTGAMSPSRLS--PNIFLNL--NIDHLGLERGG 157
            ..  .|     :..|.||.|:   .|.:.:...:.:|.||.::  |...||.  |:::|......
  Rat   199 KS--FPFFNSMNVNPLSSQSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSPSLN 261

  Fly   158 SGLSMEWSTYPPQTQAQTHPQMDSDN--------QLQQHPPQQHAS 195
            |.:......|.|.|....:  .|:.|        :.:||....:||
  Rat   262 SAVPTPACPYAPPTPPYVY--RDTCNSSLASLRLKAKQHSSFGYAS 305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pph13	NP_477330.1	Homeodomain	11..67	CDD:459649	37/55 (67%)
Pitx2	NP_001035970.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	57..111		16/39 (41%)
		Homeodomain	93..149	CDD:459649	37/55 (67%)
		OAR	282..299	CDD:461067	3/16 (19%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	286..299		1/12 (8%)
		Nuclear localization signal. /evidence=ECO:0000255	292..296		0/3 (0%)