Protein Alignment Pph13 and PITX2

DIOPT Version :10

• Sequence 1: NP_477330.1
• Gene: Pph13 / 33239
• FlyBaseID: FBgn0023489
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_000316.2
• Gene: PITX2 / 5308
• HGNCID: 9005
• Length: 324
• Species: Homo sapiens
• Alignment Length: 223
• Identity: 74/223 - (33%)
• Similarity: 107/223 - (47%)
• Gaps: 40/223 - (17%)

  Fly     7 KRKQRRYRTTFNTLQLQELERAFQRTHYPDVFFREELAVRIDLTEARVQVWFQNRRAKWRKQEK- 70
            |::|||.||.|.:.||||||..|||..|||:..|||:||..:||||||:|||:||||||||:|:
Human    89 KKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERN 153

  Fly    71 -------------IGGLGGDYKEGALDLDVSYDDSAVLGQLDSALGGGGTLLP-----DTPPQSS 117
                         ..||...|.:  :....||::.|..|...::|....  .|     :..|.||
Human   154 QQAELCKNGFGPQFNGLMQPYDD--MYPGYSYNNWAAKGLTSASLSTKS--FPFFNSMNVNPLSS 214

  Fly   118 NSL---DNELKASYGTGAMSPSRLS--PNIFLNL--NIDHLGLERGGSGLSMEWSTYPPQTQAQT 175
            .|:   .|.:.:...:.:|.||.::  |...||.  |:::|......|.:......|.|.|....
Human   215 QSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTPPYV 279

  Fly   176 HPQMDSDN--------QLQQHPPQQHAS 195
            :  .|:.|        :.:||....:||
Human   280 Y--RDTCNSSLASLRLKAKQHSSFGYAS 305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pph13	NP_477330.1	Homeodomain	11..67	CDD:459649	37/55 (67%)
PITX2	NP_000316.2	Homeodomain	93..149	CDD:459649	37/55 (67%)
		OAR	282..299	CDD:461067	3/16 (19%)