Protein Alignment Pph13 and OTX1

DIOPT Version :10

• Sequence 1: NP_477330.1
• Gene: Pph13 / 33239
• FlyBaseID: FBgn0023489
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_055377.1
• Gene: OTX1 / 5013
• HGNCID: 8521
• Length: 354
• Species: Homo sapiens
• Alignment Length: 330
• Identity: 89/330 - (26%)
• Similarity: 122/330 - (36%)
• Gaps: 111/330 - (33%)

  Fly     8 RKQRRYRTTFNTLQLQELERAFQRTHYPDVFFREELAVRIDLTEARVQVWFQNRRAKWRKQEKIG 72
            |||||.||||...||..||..|.:|.|||:|.|||:|::|:|.|:||||||:|||||.|:|::.|
Human    36 RKQRRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSG 100

  Fly    73 G---------------------LGGDYKEGALDLDVSYDDSAVLGQLDSA------LGGG----- 105
            .                     ..|.:...|:....|...||.....:.|      |||.
Human   101 SGTKSRPAKKKSSPVRESSGSESSGQFTPPAVSSSASSSSSASSSSANPAAAAAAGLGGNPVAAA 165

  Fly   106 --------------GTLLPDTPPQSSNSLDNELKA------------------------------ 126
                          .::.|.:.| :|.|:...|.|
Human   166 SSLSTPAASSIWSPASISPGSAP-ASVSVPEPLAAPSNTSCMQRSVAAGAATAAASYPMSYGQGG 229

  Fly   127 SYGTGAMSPSRLSPNIFLNLNIDHLGLERGGSGLSMEWSTYPPQTQAQTHPQ----MDSDNQLQQ 187
            |||.|..:|   |.:.|            ||    ::.|:|.....:..||.    |...:....
Human   230 SYGQGYPTP---SSSYF------------GG----VDCSSYLAPMHSHHHPHQLSPMAPSSMAGH 275

  Fly   188 HPPQQHASDPIHAGSSSHHQQQQQQHQQEQHNPQLHPGLEFAASLSLDMTD-----GSSAYDEMK 247
            |....||..|:...|..||     .|....|......||.|.::..||..:     .|||: ::.
Human   276 HHHHPHAHHPLSQSSGHHH-----HHHHHHHQGYGGSGLAFNSADCLDYKEPGAAAASSAW-KLN 334

  Fly   248 FLSVD 252
            |.|.|
Human   335 FNSPD 339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pph13	NP_477330.1	Homeodomain	11..67	CDD:459649	34/55 (62%)
OTX1	NP_055377.1	Homeodomain	39..95	CDD:459649	34/55 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..146		10/54 (19%)
		TF_Otx	178..274	CDD:427350	20/115 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..305		12/52 (23%)