Protein Alignment Pph13 and pitx3

DIOPT Version :10

• Sequence 1: NP_477330.1
• Gene: Pph13 / 33239
• FlyBaseID: FBgn0023489
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_991238.1
• Gene: pitx3 / 402974
• ZFINID: ZDB-GENE-041229-4
• Length: 293
• Species: Danio rerio
• Alignment Length: 286
• Identity: 85/286 - (29%)
• Similarity: 119/286 - (41%)
• Gaps: 75/286 - (26%)

  Fly     2 DKGTMKRKQRRYRTTFNTLQLQELERAFQRTHYPDVFFREELAVRIDLTEARVQVWFQNRRAKWR 66
            :.|::|:||||.||.|.:.||||||..|||..|||:..|||:||..:||||||:|||:|||||||
Zfish    52 EDGSLKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWR 116

  Fly    67 KQEK-------IGGLGGDYKEGALDLDVSYDDSAVLGQLDSALGGGGTLLPDTPPQSSNSLDNEL 124
            |:|:       ..|.|..:.    .|...|||.                      .|..|.:|
Zfish   117 KRERNQQAELCKNGFGAQFN----GLMQPYDDM----------------------YSGYSYNN-- 153

  Fly   125 KASYGTGAMSPSRLSPN---IFLNLNIDHLGLERGGSGLSMEWSTYPPQTQAQTHPQMDSDNQLQ 186
               :.|.:::.|.||..   .|.::|:         |.||.:....||.:       :.|.|...
Zfish   154 ---WATKSLASSPLSAKSFPFFNSMNV---------SPLSSQPMFSPPSS-------IPSMNMAS 199

  Fly   187 QHPPQQHASDPIHAGSSSHHQQQQQQHQQEQHNPQLHPGLEFAASLSLDMTDGSSAYDEMKFLSV 251
            ...|...|..|   ||..::    ..:....::|.|:.....||:.....|.|...|.:
Zfish   200 SMVPSAVAGVP---GSGLNN----LGNLNNLNSPTLNSAAVSAAACPYATTAGPYMYRD------ 251

  Fly   252 DVDQFTIDSFKADCILSMEQSQMQAY 277
                 |.:|..|...|..:|....||
Zfish   252 -----TCNSSLASLRLKAKQHANFAY 272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pph13	NP_477330.1	Homeodomain	11..67	CDD:459649	37/55 (67%)
pitx3	NP_991238.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..69		9/16 (56%)
		Homeodomain	61..117	CDD:459649	37/55 (67%)
		OAR	251..268	CDD:461067	5/27 (19%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	255..268		4/12 (33%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O35160	260..264		1/3 (33%)