Protein Alignment Pph13 and VSX2

DIOPT Version :10

• Sequence 1: NP_477330.1
• Gene: Pph13 / 33239
• FlyBaseID: FBgn0023489
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_878314.1
• Gene: VSX2 / 338917
• HGNCID: 1975
• Length: 361
• Species: Homo sapiens
• Alignment Length: 220
• Identity: 80/220 - (36%)
• Similarity: 104/220 - (47%)
• Gaps: 39/220 - (17%)

  Fly     5 TMKRKQRRYRTTFNTLQLQELERAFQRTHYPDVFFREELAVRIDLTEARVQVWFQNRRAKWRKQE 69
            |.|||:||:||.|.:.||:|||:||...|||||:.||.||::.:|.|.|:|||||||||||||:|
Human   143 TKKRKKRRHRTIFTSYQLEELEKAFNEAHYPDVYAREMLAMKTELPEDRIQVWFQNRRAKWRKRE 207

  Fly    70 KIG---------GLGGDYKEGALDLDVSYDDSAVLGQLDSA----LGGGGTLL---------PDT 112
            |..         ||.|.....::.|..|...||..|.:||.    ||.....|         |:.
Human   208 KCWGRSSVMAEYGLYGAMVRHSIPLPESILKSAKDGIMDSCAPWLLGMHKKSLEAAAESGRKPEG 272

  Fly   113 PPQSSNSLDNELKASYG---TGAMSPSRLSPNIFLNLNI---DH----LGLERGGSGLSMEWSTY 167
            ..|:...||...:...|   ..|:|...|..|....|..   :|    ||...|...|:.  ||.
Human   273 ERQALPKLDKMEQDERGPDAQAAISQEELRENSIAVLRAKAQEHSTKVLGTVSGPDSLAR--STE 335

  Fly   168 PPQTQAQTHPQMDSDNQLQQ-HPPQ 191
            .|:.:    ..||.|...:: .|||
Human   336 KPEEE----EAMDEDRPAERLSPPQ 356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pph13	NP_477330.1	Homeodomain	11..67	CDD:459649	35/55 (64%)
VSX2	NP_878314.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	104..151		5/7 (71%)
		Homeodomain	153..205	CDD:459649	32/51 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..300		7/37 (19%)
		OAR	300..318	CDD:461067	4/17 (24%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	304..317		2/12 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..361		14/50 (28%)