Protein Alignment Pph13 and HOXA3

DIOPT Version :10

• Sequence 1: NP_477330.1
• Gene: Pph13 / 33239
• FlyBaseID: FBgn0023489
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_109377.1
• Gene: HOXA3 / 3200
• HGNCID: 5104
• Length: 443
• Species: Homo sapiens
• Alignment Length: 266
• Identity: 61/266 - (22%)
• Similarity: 92/266 - (34%)
• Gaps: 93/266 - (34%)

  Fly    11 RRYRTTFNTLQLQELERAFQRTHYPDVFFREELAVRIDLTEARVQVWFQNRRAKWRKQEKIGGL- 74
            :|.||.:.:.||.|||:.|....|.....|.|:|..::|||.::::||||||.|::|.:|..|:
Human   192 KRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGML 256

  Fly    75 ----------------GGDYKEGALDL--DVSYD------------------DSAVLGQLDS--- 100
                            .|.|......|  .|.|:                  .::....|.|
Human   257 TSSGGQSPSRSPVPPGAGGYLNSMHSLVNSVPYEPQSPPPFSKPPQGTYGLPPASYPASLPSCAP 321

  Fly   101 -----------ALGGGGTLLPDTPPQSSNSLDNELKASYGTGAM--SP-----------SRLSPN 141
                       ..|.|||  ||..|.:.....|   .||||..:  ||           |...|.
Human   322 PPPPQKRYTAAGAGAGGT--PDYDPHAHGLQGN---GSYGTPHIQGSPVFVGGSYVEPMSNSGPA 381

  Fly   142 IFLNLNIDHL---GLERGGSGLSMEWSTYPPQTQAQTHPQMDSDNQLQQHPPQQHASDPIHAGSS 203
            :|...::.|.   .::.||:|                  .:.|.:.....|.:.|   |.:...:
Human   382 LFGLTHLPHAASGAMDYGGAG------------------PLGSGHHHGPGPGEPH---PTYTDLT 425

  Fly   204 SHHQQQ 209
            .||..|
Human   426 GHHPSQ 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pph13	NP_477330.1	Homeodomain	11..67	CDD:459649	23/55 (42%)
HOXA3	NP_109377.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	75..147
		Antp-type hexapeptide	155..160
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..196		1/3 (33%)
		Homeodomain	192..248	CDD:459649	23/55 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	247..338		11/90 (12%)
		DUF4074	377..441	CDD:463833	13/76 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..443		9/53 (17%)