DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pph13 and arxa

DIOPT Version :9

Sequence 1:	NP_477330.1	Gene:	Pph13 / 33239	FlyBaseID:	FBgn0023489	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_571459.1	Gene:	arxa / 30657	ZFINID:	ZDB-GENE-990415-15	Length:	453	Species:	Danio rerio

Alignment Length:	256	Identity:	98/256 - (38%)
Similarity:	123/256 - (48%)	Gaps:	60/256 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DKGTMKRKQRRYRTTFNTLQLQELERAFQRTHYPDVFFREELAVRIDLTEARVQVWFQNRRAKWR 66
            ::|.:|||||||||||.:.||:|||||||:|||||||.|||||:|:|||||||||||||||||||
Zfish   207 EEGMLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWR 271

  Fly    67 KQEKIG------GLGGDYKEGALDLDVSYDDSAVLGQLDSALGGGGTLLPDTPPQSSNSLDNELK 125
            |:||.|      ||.   ..|.|         |....|...|.||     ..||....:|::...
Zfish   272 KREKAGVQAHPTGLP---FPGPL---------AAAHPLSHYLEGG-----PFPPHPHPALESAWT 319

  Fly   126 ASYGTGAMSP--------SRLSPNIFLNLNIDHLGLERG------GSGLSMEWSTYPPQTQA--- 173
            |:....|..|        |.|.|...|.|. ..||....      |......:|:..|.|.|
Zfish   320 AAAAAAAAFPGLAPPPNSSALPPATPLGLG-TFLGTAMFRHPAFIGPTFGRLFSSMGPLTSASTA 383

  Fly   174 -----QTHPQMDSDNQLQQHPPQQHASDPIHAGSSSHHQQQQQ-------QHQQEQHNPQL 222
                 ||.|.::|       |.|..|:.|....|||.....::       :.:.::|:.||
Zfish   384 AALLRQTAPPVES-------PVQPSAALPEPPSSSSSTAADRRASSIAALRLKAKEHSAQL 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pph13	NP_477330.1	Homeobox	14..66	CDD:278475	43/51 (84%)
arxa	NP_571459.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..75
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..149
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..212		1/4 (25%)
		Homeobox	219..271	CDD:278475	43/51 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	390..418		10/34 (29%)
		OAR	417..434	CDD:281777	0/16 (0%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	421..434		0/12 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BSUU
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5874
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950