DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pph13 and RAX

DIOPT Version :9

Sequence 1:	NP_477330.1	Gene:	Pph13 / 33239	FlyBaseID:	FBgn0023489	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_038463.2	Gene:	RAX / 30062	HGNCID:	18662	Length:	346	Species:	Homo sapiens

Alignment Length:	236	Identity:	81/236 - (34%)
Similarity:	99/236 - (41%)	Gaps:	66/236 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KRKQRRYRTTFNTLQLQELERAFQRTHYPDVFFREELAVRIDLTEARVQVWFQNRRAKWRKQEKI 71
            |:|.||.||||.|.||.||||||:::|||||:.|||||.:::|.|.||||||||||||||:|||:
Human   133 KKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRVQVWFQNRRAKWRRQEKL 197

  Fly    72 ------------------------------GGLGGDYKEGALDLDVSYDDSAVLGQLDSALGGGG 106
                                          .|.||....|||.|:      :.||  ....|||.
Human   198 EVSSMKLQDSPLLSFSRSPPSATLSPLGAGPGSGGGPAGGALPLE------SWLG--PPLPGGGA 254

  Fly   107 TLLPDT----PPQSSNSLDNELKASYGTGAMSPSRL-SPNIFLNLNIDHLGLERGGSGLSMEWST 166
            |.|...    ||..|      |.|||......|..| ||.:              |.||.   ..
Human   255 TALQSLPGFGPPAQS------LPASYTPPPPPPPFLNSPPL--------------GPGLQ---PL 296

  Fly   167 YPPQTQAQTHPQMDSDNQLQQHPPQQHASDPIHAGSSSHHQ 207
            .||.......|.......|.:..|:..:...:...:..|.|
Human   297 APPPPSYPCGPGFGDKFPLDEADPRNSSIAALRLKAKEHIQ 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pph13	NP_477330.1	Homeobox	14..66	CDD:278475	37/51 (73%)
RAX	NP_038463.2	Octapeptide motif	33..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..145		8/11 (73%)
		Homeobox	140..192	CDD:278475	37/51 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..318		35/154 (23%)
		OAR	319..335	CDD:281777	1/15 (7%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	323..336		0/12 (0%)
		Nuclear localization signal. /evidence=ECO:0000255	329..333		0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920