DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pph13 and ALX3

DIOPT Version :9

Sequence 1:	NP_477330.1	Gene:	Pph13 / 33239	FlyBaseID:	FBgn0023489	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_006483.2	Gene:	ALX3 / 257	HGNCID:	449	Length:	343	Species:	Homo sapiens

Alignment Length:	143	Identity:	70/143 - (48%)
Similarity:	89/143 - (62%)	Gaps:	26/143 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDKGTMKRKQRRYRTTFNTLQLQELERAFQRTHYPDVFFREELAVRIDLTEARVQVWFQNRRAKW 65
            |:....|.|:||.||||:|.||:|||:.||:||||||:.||:||:|.||||||||||||||||||
Human   144 MELAKNKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKW 208

  Fly    66 RKQEKIGGLGGDYKEGALDLDVSYDDSAVLGQLDSALGGGGTLLP--DTPPQSSNSLDNELKASY 128
            ||:|:.|.:    :||......:||.|               :||  |:.||    |.|.|.||.
Human   209 RKRERYGKI----QEGRNPFTAAYDIS---------------VLPRTDSHPQ----LQNSLWASP 250

  Fly   129 GTGAM-SPSRLSP 140
            |:|:. .|..:||
Human   251 GSGSPGGPCLVSP 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pph13	NP_477330.1	Homeobox	14..66	CDD:278475	40/51 (78%)
ALX3	NP_006483.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..104
		PRK12323	<13..131	CDD:237057
		Homeobox	157..210	CDD:365835	41/52 (79%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41860
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5874
SonicParanoid	1	1.000	-	-		X469
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	7.050