Protein Alignment Pph13 and Otx2

DIOPT Version :10

• Sequence 1: NP_477330.1
• Gene: Pph13 / 33239
• FlyBaseID: FBgn0023489
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_001273410.1
• Gene: Otx2 / 18424
• MGIID: 97451
• Length: 297
• Species: Mus musculus
• Alignment Length: 288
• Identity: 90/288 - (31%)
• Similarity: 123/288 - (42%)
• Gaps: 65/288 - (22%)

  Fly     8 RKQRRYRTTFNTLQLQELERAFQRTHYPDVFFREELAVRIDLTEARVQVWFQNRRAKWRKQEKIG 72
            |||||.||||...||..||..|.:|.|||:|.|||:|::|:|.|:||||||:|||||.|:|::..
Mouse    44 RKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQ 108

  Fly    73 GLGGDYKEGALDLDVSYDDSAVLGQLDSALGGGGTLLPDTPPQSSNSLDNELKASYGTGAMSPSR 137
            ..||..|     :..:...|:...::.|..|..|..   :|| ||.|:.....:|......||:.
Mouse   109 QNGGQNK-----VRPAKKKSSPAREVSSESGTSGQF---SPP-SSTSVPTIASSSAPVSIWSPAS 164

  Fly   138 LSPNIFLNLNIDHLGLERGGSGLSMEWSTYP-PQTQAQTHPQ-----------MDSDNQL----Q 186
            :||          |......|...|:.| || ..|||..:.|           ||..:.|    .
Mouse   165 ISP----------LSDPLSTSSSCMQRS-YPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHH 218

  Fly   187 QHPPQQHASDPIHAGSSSHHQQQQQQHQQEQHNPQLHPGLEFAASLSLDMTDGSSAYDEMKFLS- 250
            |.|.......|:...:.:.|..|.                  .||||   |.|..| ..:.|.|
Mouse   219 QLPGPGATLSPMGTNAVTSHLNQS------------------PASLS---TQGYGA-SSLGFNST 261

  Fly   251 ---VDVDQFTID---SFKADCILSMEQS 272
               :|....|..   :|.|||:...:|:
Mouse   262 TDCLDYKDQTASWKLNFNADCLDYKDQT 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pph13	NP_477330.1	Homeodomain	11..67	CDD:459649	34/55 (62%)
Otx2	NP_001273410.1	Homeodomain	47..102	CDD:459649	34/54 (63%)
		TF_Otx	161..242	CDD:427350	21/91 (23%)