DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pph13 and Arx

DIOPT Version :9

Sequence 1:	NP_477330.1	Gene:	Pph13 / 33239	FlyBaseID:	FBgn0023489	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_001292869.1	Gene:	Arx / 11878	MGIID:	1097716	Length:	564	Species:	Mus musculus

Alignment Length:	254	Identity:	93/254 - (36%)
Similarity:	120/254 - (47%)	Gaps:	49/254 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DKGTMKRKQRRYRTTFNTLQLQELERAFQRTHYPDVFFREELAVRIDLTEARVQVWFQNRRAKWR 66
            ::|.:|||||||||||.:.||:|||||||:|||||||.|||||:|:|||||||||||||||||||
Mouse   322 EEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWR 386

  Fly    67 KQEKIG------GLGGDYKEGALDLDVSYDDSAVL----GQLDS----ALGGGGTLLPDTPPQSS 117
            |:||.|      ||.......|......|.|::..    ..|||    |........|..||..
Mouse   387 KREKAGAQTHPPGLPFPGPLSATHPLSPYLDASPFPPHHPALDSAWTAAAAAAAAAFPSLPPPP- 450

  Fly   118 NSLDNELKASYGTGAMSPS--RLSPNIFLNLNI-DHLGLERGGSGLSMEWSTYPPQTQAQTHPQM 179
                       |:.::.||  .|..:.||...: .|........|  ..:||..|.|.|.|...:
Mouse   451 -----------GSASLPPSGAPLGLSTFLGAAVFRHPAFISPAFG--RLFSTMAPLTSASTAAAL 502

  Fly   180 DSDNQLQQHPPQQHA-------SDPI------HAGSSSHHQQQQQQHQQEQHNPQLHPG 225
                 |:|..|....       :||.      .|.|.:..:.:.::|..:.....:.||
Mouse   503 -----LRQPTPAVEGAVASGALADPATAAADRRASSIAALRLKAKEHAAQLTQLNILPG 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pph13	NP_477330.1	Homeobox	14..66	CDD:278475	43/51 (84%)
Arx	NP_001292869.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	54..79
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	111..264
		Homeobox	334..386	CDD:278475	43/51 (84%)
		OAR	528..545	CDD:281777	2/16 (13%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	532..545		1/12 (8%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BSUU
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43910
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5874
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950