DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ipk2 and Ip6k1

DIOPT Version :9

Sequence 1:	NP_608535.1	Gene:	Ipk2 / 33236	FlyBaseID:	FBgn0031267	Length:	309	Species:	Drosophila melanogaster
Sequence 2:	NP_445768.1	Gene:	Ip6k1 / 50560	RGDID:	71025	Length:	433	Species:	Rattus norvegicus

Alignment Length:	254	Identity:	71/254 - (27%)
Similarity:	112/254 - (44%)	Gaps:	67/254 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 NRRERTFLRLEDLTRSYAKPCVMDVKMGKRTWDPESSPNK-----RKVEEAKYVMCKQKLGLCLP 153
            :|:...||.||::...:..|||:|:|||.|....::|..|     ||.|::    ....||:.:.
  Rat   201 DRKLYKFLLLENVVHHFKYPCVLDLKMGTRQHGDDASAEKAARQMRKCEQS----TSASLGVRVC 261

  Fly   154 GFQVYLPKEEHTQETTILRHGKDYGKSLNVEGFKQTMALFFNASTSDSKSRRAGCEL---LLKEV 215
            |.|||.....|     .|...|.||:.|::|||:..:..:.:          .|.:|   |.:.:
  Rat   262 GMQVYQLDTGH-----YLCRNKYYGRGLSIEGFRNALYQYLH----------NGLDLRRDLFEPI 311

  Fly   216 LRQLQEILAWFQRQRLLHFYASSLLICYD-----------YSRLADPPKPLINGYHQNDDDPAT- 268
            |.:|:.:.|..:||....||:||||:.||           :..:..|..|.:.|       |:|
  Rat   312 LSKLRGLKAVLERQASYRFYSSSLLVIYDGKECRSELRLKHVDMGLPEVPPLCG-------PSTS 369

  Fly   269 --------------WVRVKMIDFAHVY-------PAEQGLPDENYMFGLQSLIEVVQSI 306
                          .|.|:||||||..       |.....||..|:|||::||.:::.:
  Rat   370 PSNTSLEAGPSSPPKVDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQM 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ipk2	NP_608535.1	IPK	100..304	CDD:281727	70/244 (29%)
Ip6k1	NP_445768.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..160
		IPK	207..426	CDD:397715	70/244 (29%)
		Substrate binding. /evidence=ECO:0000250	220..228		5/7 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..383		3/27 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1620
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D452635at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820