DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ipk2 and ipmk-1

DIOPT Version :9

Sequence 1:	NP_608535.1	Gene:	Ipk2 / 33236	FlyBaseID:	FBgn0031267	Length:	309	Species:	Drosophila melanogaster
Sequence 2:	NP_502402.3	Gene:	ipmk-1 / 191426	WormBaseID:	WBGene00014081	Length:	297	Species:	Caenorhabditis elegans

Alignment Length:	325	Identity:	96/325 - (29%)
Similarity:	158/325 - (48%)	Gaps:	55/325 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SDQELPEGFRQLKTQVAGH--TFEESNAEAVGLLQDSKAGCVLKPLGKPECGERELRFYESLAEA 66
            |:..|||.::....|:|||  :..::....:|||:...:..:|||......||:|:..||.|...
Worm     5 SNDGLPEKYQWFSDQIAGHHPSVIKNGKREIGLLKIPGSREILKPKQDASRGEKEVALYELLRSC 69

  Fly    67 GAS-------------------GDNDLLALLRGHVPRFYGPLKLVVNRRERTFLRLEDLTRSYAK 112
            ..|                   .|.::|..|...   |||...:.|:.::|.||.:||:|..|.:
Worm    70 TTSPSTPPESTTSDELRKRVRMEDIEMLCKLTAD---FYGIQTIFVDGQDREFLAMEDVTIGYQR 131

  Fly   113 PCVMDVKMGKRTWDPESSPNKRKVEEAKYVMCKQKLGLCLPGFQVYLPKEEHTQETTILRHGKDY 177
            |.::|:|||:.|:||.:.|.|.:.|..||.. :.|:|:.:.|:::      |..:..:....||:
Worm   132 PAILDLKMGQVTYDPIAKPEKIEKERIKYPP-QAKMGMRILGYRI------HRSDNQVEVRDKDW 189

  Fly   178 GKSLNVEGFKQTMALFFNASTSDSKSRRAGCELLLKEVLRQLQEILAWFQRQRLLHFYASSLLIC 242
            |||.:....:..:..||:|.:      .|....:|.|.|.:|:.|..:|:.||.|.|:|||||..
Worm   190 GKSFDETTVETGLREFFSARS------EADLNQVLLEALDKLKIIKNFFETQRSLQFFASSLLFV 248

  Fly   243 YDYSRLADPPKPLINGYHQNDDDPATWVRVKMIDFAHVYPAEQGLPDENYMFGLQSLIEVVQSIL 307
            ::    ||...| ||            :|:.||||:|.: |..|.||..|..|:|:|.:.:.:|:
Worm   249 FE----ADKELP-IN------------MRIVMIDFSHAF-ASSGEPDNGYSLGIQNLEKFLNNII 295

Fly 308 307
Worm 296 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ipk2	NP_608535.1	IPK	100..304	CDD:281727	66/203 (33%)
ipmk-1	NP_502402.3	IPK	119..292	CDD:281727	66/203 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162197
Domainoid	1	1.000	94	1.000	Domainoid score	I4752
eggNOG	1	0.900	-	-		E1_KOG1620
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H76214
Inparanoid	1	1.050	121	1.000	Inparanoid score	I3325
Isobase	1	0.950	-	0	Normalized mean entropy	S4071
OMA	1	1.010	-	-		QHG54492
OrthoDB	1	1.010	-	-		D452635at33208
OrthoFinder	1	1.000	-	-		FOG0003587
OrthoInspector	1	1.000	-	-		oto19069
orthoMCL	1	0.900	-	-		OOG6_104761
Panther	1	1.100	-	-	LDO	PTHR12400
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3597
SonicParanoid	1	1.000	-	-		X2060
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750