DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sf3b1 and HSH155

DIOPT Version :9

Sequence 1:	NP_001259837.1	Gene:	Sf3b1 / 33235	FlyBaseID:	FBgn0031266	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_014015.1	Gene:	HSH155 / 855332	SGDID:	S000004901	Length:	971	Species:	Saccharomyces cerevisiae

Alignment Length:	920	Identity:	467/920 - (50%)
Similarity:	621/920 - (67%)	Gaps:	20/920 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   421 RWEKEIDERNRPYTDEELDQIFPPGYKILPPPAGYVPLRTPGRKLMATPTPIAGTPAGFFIQVED 485
            ::|.:.|.:....::...|.:.|...|......||.|             |...:.|     |::
Yeast    72 KFEPDSDTQTVTSSENTQDAVVPRKRKSRWDVKGYEP-------------PDESSTA-----VKE 118

  Fly   486 KNAKFMDNQPKGQNLPFMKPEDAQYFDKLLVDVNEDSLSPEELKERKIMKLLLTIKNGSPPMRKS 550
            .:...:.|.....:|.|.||.|.:||..::.....|.|:.:|.|||.:..|||.||||:...|::
Yeast   119 NSDSALVNVEGIHDLMFFKPSDHKYFADVISKKPIDELNKDEKKERTLSMLLLKIKNGNTASRRT 183

  Fly   551 ALRQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRVLYKLDDLVRPYVHKILVVIE 615
            ::|.:||||..||...:||::||:|:..:||||||||::|.||||||:|.||.:|||||||||..
Yeast   184 SMRILTDKAVTFGPEMIFNRLLPILLDRSLEDQERHLMIKTIDRVLYQLGDLTKPYVHKILVVAA 248

  Fly   616 PLLIDEDHYARIEGREIISNLAKAAGLATMISTMRPDIDNIDEYVRNTTARAFAVVASALGIPSL 680
            |||||||...|..|:|||:||:..|||.|:::.|||||:|.||||||.|:||.||||.|||:..|
Yeast   249 PLLIDEDPMVRSTGQEIITNLSTVAGLKTILTVMRPDIENEDEYVRNVTSRAAAVVAKALGVNQL 313

  Fly   681 LPFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLKALVEIIEHGLVDEQQKVRTITALAI 745
            |||:.|.|.|:|||:||||||||||||.||:|..:|.||..|:..|:..|:|:...||.:||..:
Yeast   314 LPFINAACHSRKSWKARHTGIKIVQQIGILLGIGVLNHLTGLMSCIKDCLMDDHVPVRIVTAHTL 378

  Fly   746 AALAEAATPYGIESFDSVLKPLWKGIRTHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILI 810
            :.|||.:.|||||.|:.||:|||||||:||||.|::||||:|.:|||||.|||.|||.|.|.|:.
Yeast   379 STLAENSYPYGIEVFNVVLEPLWKGIRSHRGKVLSSFLKAVGSMIPLMDPEYAGYYTTEAMRIIR 443

  Fly   811 REFQSPDEEMKKIVLKVVKQCCATDGVEPQYIKEEILPHFFKFFWNHRMALDRRNYRQLVDTTVE 875
            |||.|||:||||.:|.|:::|.|.:.:.|::::|||.|.||:.||..|:||||...:.:..|||.
Yeast   444 REFDSPDDEMKKTILLVLQKCSAVESITPKFLREEIAPEFFQKFWVRRVALDRPLNKVVTYTTVT 508

  Fly   876 IANKVGASEIINRVVDDLKDENEQYRKMVMETVEKIMGNLGAADIDSRLEEQLIDGILYAFQEQT 940
            :|.|:|.|..|::::..|:||.|.:|.|.:..|.:.:..||.||:|.|||.:|||.:|.||||||
Yeast   509 LAKKLGCSYTIDKLLTPLRDEAEPFRTMAVHAVTRTVNLLGTADLDERLETRLIDALLIAFQEQT 573

  Fly   941 TEDVVMLNGFGTIVNQLGKRVKPYLPQICGTILWRLNNKSAKVRQQAADLISRIAVVMKTCQEEK 1005
            ..|.::..|||.:...|..|:||:|..|..|||..|.:|:..|||.||||.:.:..|:|.|.|.:
Yeast   574 NSDSIIFKGFGAVTVSLDIRMKPFLAPIVSTILNHLKHKTPLVRQHAADLCAILIPVIKNCHEFE 638

  Fly  1006 LMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMTKMTPPIKDLLPRLTPILKNRHEKVQEN 1070
            ::..|.::|||.|||.||||||||:.|:..|.:|:.:.|:.|||..:||.|||||:|:|.||:.|
Yeast   639 MLNKLNIILYESLGEVYPEVLGSIINAMYCITSVMDLDKLQPPINQILPTLTPILRNKHRKVEVN 703

  Fly  1071 CIDLVGRIADRGPEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLN 1135
            .|..||.|....|.|...:||||||||||||||:..|.|||:...|||:||:||||||||..|||
Yeast   704 TIKFVGLIGKLAPTYAPPKEWMRICFELLELLKSTNKEIRRSANATFGFIAEAIGPHDVLVALLN 768

  Fly  1136 NLKVQERQNRVCTTVAIAIVAESCRPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKD 1200
            ||||||||.||||.|||.|||:.|.|:.|||.:||||..||.||||||||::||:|||||.|.||
Yeast   769 NLKVQERQLRVCTAVAIGIVAKVCGPYNVLPVIMNEYTTPETNVQNGVLKAMSFMFEYIGNMSKD 833

  Fly  1201 YIYAVCPLLEDALMDRDLVHRQTACSAIKHMSLGVYGFGCEDALTHLLNYVWPNIFETSPHLVQA 1265
            |||.:.|||||||.||||||||||.:.|.|::|...|.|.|||..||:|.:.|||||||||.:..
Yeast   834 YIYFITPLLEDALTDRDLVHRQTASNVITHLALNCSGTGHEDAFIHLMNLLIPNIFETSPHAIMR 898

  Fly  1266 FMDSVDGLRVSLGPIKILQYTLQGLFHPARKVRDVYWKIYNSLYIGGQDALIAGYPRITNDPKNQ 1330
            .::.::.|..:|||...:.|...||||||:.||..:|::||::|:..|||::..|| :|.|...:
Yeast   899 ILEGLEALSQALGPGLFMNYIWAGLFHPAKNVRKAFWRVYNNMYVMYQDAMVPFYP-VTPDNNEE 962

  Fly  1331 YERYELDYTL 1340
            |.. |||..|
Yeast   963 YIE-ELDLVL 971

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sf3b1	NP_001259837.1	SF3b1	340..477	CDD:286064	9/55 (16%)
		HSH155	483..1340	CDD:227508	456/856 (53%)
		HEAT repeat	500..521	CDD:293787	7/20 (35%)
		HEAT repeat	533..560	CDD:293787	12/26 (46%)
		HEAT repeat	570..598	CDD:293787	17/27 (63%)
		HEAT repeat	609..635	CDD:293787	17/25 (68%)
		HEAT repeat	642..670	CDD:293787	17/27 (63%)
		HEAT repeat	680..709	CDD:293787	22/28 (79%)
		HEAT repeat	805..830	CDD:293787	14/24 (58%)
		HEAT repeat	886..910	CDD:293787	8/23 (35%)
		HEAT repeat	924..955	CDD:293787	16/30 (53%)
		HEAT_EZ	947..994	CDD:290247	21/46 (46%)
		HEAT repeat	967..1000	CDD:293787	14/32 (44%)
		HEAT repeat	1009..1035	CDD:293787	16/25 (64%)
		ARM	1016..1117	CDD:237987	55/100 (55%)
		HEAT repeat	1049..1078	CDD:293787	16/28 (57%)
		HEAT repeat	1098..1119	CDD:293787	12/20 (60%)
		HEAT repeat	1129..1157	CDD:293787	22/27 (81%)
		HEAT repeat	1163..1193	CDD:293787	20/29 (69%)
		HEAT repeat	1204..1230	CDD:293787	18/25 (72%)
HSH155	NP_014015.1	HSH155	1..971	CDD:227508	466/918 (51%)
		HEAT repeat	279..303	CDD:293787	15/23 (65%)
		HEAT repeat	313..342	CDD:293787	22/28 (79%)
		HEAT repeat	352..383	CDD:293787	10/30 (33%)
		HEAT repeat	519..543	CDD:293787	8/23 (35%)
		HEAT repeat	561..588	CDD:293787	14/26 (54%)
		HEAT repeat	600..630	CDD:293787	13/29 (45%)
		HEAT repeat	642..671	CDD:293787	17/28 (61%)
		HEAT repeat	682..711	CDD:293787	16/28 (57%)
		HEAT repeat	727..755	CDD:293787	18/27 (67%)
		HEAT repeat	761..791	CDD:293787	24/29 (83%)
		HEAT repeat	797..822	CDD:293787	17/24 (71%)
		HEAT repeat	835..864	CDD:293787	20/28 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345477
Domainoid	1	1.000	840	1.000	Domainoid score	I2
eggNOG	1	0.900	-	-		E1_COG5181
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	898	1.000	Inparanoid score	I42
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53897
OrthoFinder	1	1.000	-	-		FOG0004708
OrthoInspector	1	1.000	-	-		oto99274
orthoMCL	1	0.900	-	-		OOG6_101702
Panther	1	1.100	-	-	LDO	PTHR12097
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1324
SonicParanoid	1	1.000	-	-		X3309
TreeFam	1	0.960	-	-
	14	13.790