DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sf3b1 and Sf3b1

DIOPT Version :9

Sequence 1:	NP_001259837.1	Gene:	Sf3b1 / 33235	FlyBaseID:	FBgn0031266	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_445878.1	Gene:	Sf3b1 / 84486	RGDID:	620148	Length:	1304	Species:	Rattus norvegicus

Alignment Length:	1363	Identity:	1044/1363 - (76%)
Similarity:	1139/1363 - (83%)	Gaps:	82/1363 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MENIPRTHEDIEAQISVIQEKKTELAKTTAAAAGVGLLDSGGFFDSDLYDDDAAKGKGRYEGYNT 65
            |..|.:|||||||||..||.||..|.:    |.||| |||.|::|.::|    .....|:.||.|
  Rat     1 MAKIAKTHEDIEAQIREIQGKKAALDE----AQGVG-LDSTGYYDQEIY----GGSDSRFAGYVT 56

  Fly    66 SIAANDAEEVDEDEDDGFP-VPQKRTTYTAPASVLKDVTQGKEDVDPMADRRRPTIADREDEYRQ 129
            ||||.:.|:.|:|...... :.||:..|.||.::|.|:.|..|..||.|:.|.|.||||||||::
  Rat    57 SIAATELEDDDDDYSSSTSLLGQKKPGYHAPVALLNDIPQSTEQYDPFAEHRPPKIADREDEYKK 121

  Fly   130 KRRHIIISPERADPFADGGKTPD--VGSRTYTDIMREQMLKGEESELRRRILEKTKEGTLVKTVT 192
            .||.:||||||.|||||||||||  :.:|||.|:||||.|..||.|:|:::.||.|.|.| |.|.
  Rat   122 HRRTMIISPERLDPFADGGKTPDPKMNARTYMDVMREQHLTKEEREIRQQLAEKAKAGEL-KVVN 185

  Fly   193 SSSTSNGDLPAPKDGGRKRGRWDQTVSDSFIPAKMATPSSAATPTWED-KTPGDH----RWDETP 252
            .::.|.   |..|   ||| |||||...:  |.  |||...:  :|:. :||| |    ||||||
  Rat   186 GAAASQ---PPSK---RKR-RWDQTADQT--PG--ATPKKLS--SWDQAETPG-HTPSLRWDETP 236

  Fly   253 GH-KGSETPGATPGLGTRIWDATPAHAV----------TPGHETPGH---EKSARRNRWDETPKT 303
            |. ||||||||||  |::|||.||:|..          ||||.||||   ..|||:|||||||||
  Rat   237 GRAKGSETPGATP--GSKIWDPTPSHTPAGAATPGRGDTPGHATPGHGGATSSARKNRWDETPKT 299

  Fly   304 ERETPGH-SGWAETPKPDRTGSGGGAESISIESTPGASKRRSRWDETPSNATPAITPTNASAMTP 367
            ||:|||| |||||||:.||     |.:||....|||||||:|||||||           ||.|
  Rat   300 ERDTPGHGSGWAETPRTDR-----GGDSIGETPTPGASKRKSRWDETP-----------ASQM-- 346

  Fly   368 NMTPSMTPHVTPGHATPMLTPGGSTPIGVKAMAMATPSAGALAAMTPEQLQAYRWEKEIDERNRP 432
                        |.:||:||| |.||||..||.||||:.|.:.:||||||||:|||:||||||||
  Rat   347 ------------GGSTPVLTP-GKTPIGTPAMNMATPTPGHIMSMTPEQLQAWRWEREIDERNRP 398

  Fly   433 YTDEELDQIFPPGYKILPPPAGYVPLRTPGRKLMATPTPIAGTPAGFFIQVEDKNAKFMDNQPKG 497
            .:|||||.:||.|||:|||||||||:|||.|||.|||||:.|. .||.:|.||:..|.:::||.|
  Rat   399 LSDEELDAMFPEGYKVLPPPAGYVPIRTPARKLTATPTPLGGM-TGFHMQTEDRTMKSVNDQPSG 462

  Fly   498 QNLPFMKPEDAQYFDKLLVDVNEDSLSPEELKERKIMKLLLTIKNGSPPMRKSALRQITDKAREF 562
             ||||:||:|.||||||||||:|.:|||||.||||||||||.||||:|||||:||||||||||||
  Rat   463 -NLPFLKPDDIQYFDKLLVDVDESTLSPEEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREF 526

  Fly   563 GAGPLFNQILPLLMSPTLEDQERHLLVKVIDRVLYKLDDLVRPYVHKILVVIEPLLIDEDHYARI 627
            ||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||:|||:
  Rat   527 GAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARV 591

  Fly   628 EGREIISNLAKAAGLATMISTMRPDIDNIDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKK 692
            ||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||
  Rat   592 EGREIISNLAKAAGLATMISTMRPDIDNMDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKK 656

  Fly   693 SWQARHTGIKIVQQIAILMGCAILPHLKALVEIIEHGLVDEQQKVRTITALAIAALAEAATPYGI 757
            |||||||||||||||||||||||||||::|||||||||||||||||||:||||||||||||||||
  Rat   657 SWQARHTGIKIVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAATPYGI 721

  Fly   758 ESFDSVLKPLWKGIRTHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKK 822
            |||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   722 ESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKK 786

  Fly   823 IVLKVVKQCCATDGVEPQYIKEEILPHFFKFFWNHRMALDRRNYRQLVDTTVEIANKVGASEIIN 887
            ||||||||||.|||||..|||.||||.|||.||.|||||||||||||||||||:||||||:|||:
  Rat   787 IVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVELANKVGAAEIIS 851

  Fly   888 RVVDDLKDENEQYRKMVMETVEKIMGNLGAADIDSRLEEQLIDGILYAFQEQTTEDVVMLNGFGT 952
            |:|||||||.||||||||||:|||||||||||||.:||||||||||||||||||||.||||||||
  Rat   852 RIVDDLKDEAEQYRKMVMETIEKIMGNLGAADIDHKLEEQLIDGILYAFQEQTTEDSVMLNGFGT 916

  Fly   953 IVNQLGKRVKPYLPQICGTILWRLNNKSAKVRQQAADLISRIAVVMKTCQEEKLMGHLGVVLYEY 1017
            :||.|||||||||||||||:|||||||||||||||||||||.|||||||||||||||||||||||
  Rat   917 VVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEY 981

  Fly  1018 LGEEYPEVLGSILGALKAIVNVIGMTKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRG 1082
            |||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||
  Rat   982 LGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRG 1046

  Fly  1083 PEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVC 1147
            .||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1047 AEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVC 1111

  Fly  1148 TTVAIAIVAESCRPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVCPLLEDA 1212
            ||||||||||:|.|||||||||||||||||||||||||||||||||||||||||||||.||||||
  Rat  1112 TTVAIAIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDA 1176

  Fly  1213 LMDRDLVHRQTACSAIKHMSLGVYGFGCEDALTHLLNYVWPNIFETSPHLVQAFMDSVDGLRVSL 1277
            ||||||||||||.:.::|||||||||||||:|.|||||||||:||||||::||.|.:::||||::
  Rat  1177 LMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLRVAI 1241

  Fly  1278 GPIKILQYTLQGLFHPARKVRDVYWKIYNSLYIGGQDALIAGYPRITNDPKNQYERYELDYTL 1340
            ||.::|||.|||||||||||||||||||||:|||.||||||.||||.||.||.|.||||||.|
  Rat  1242 GPCRMLQYCLQGLFHPARKVRDVYWKIYNSIYIGSQDALIAHYPRIYNDDKNTYIRYELDYIL 1304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sf3b1	NP_001259837.1	SF3b1	340..477	CDD:286064	81/136 (60%)
		HSH155	483..1340	CDD:227508	775/856 (91%)
		HEAT repeat	500..521	CDD:293787	16/20 (80%)
		HEAT repeat	533..560	CDD:293787	23/26 (88%)
		HEAT repeat	570..598	CDD:293787	26/27 (96%)
		HEAT repeat	609..635	CDD:293787	23/25 (92%)
		HEAT repeat	642..670	CDD:293787	26/27 (96%)
		HEAT repeat	680..709	CDD:293787	28/28 (100%)
		HEAT repeat	805..830	CDD:293787	24/24 (100%)
		HEAT repeat	886..910	CDD:293787	19/23 (83%)
		HEAT repeat	924..955	CDD:293787	28/30 (93%)
		HEAT_EZ	947..994	CDD:290247	43/46 (93%)
		HEAT repeat	967..1000	CDD:293787	30/32 (94%)
		HEAT repeat	1009..1035	CDD:293787	25/25 (100%)
		ARM	1016..1117	CDD:237987	98/100 (98%)
		HEAT repeat	1049..1078	CDD:293787	28/28 (100%)
		HEAT repeat	1098..1119	CDD:293787	20/20 (100%)
		HEAT repeat	1129..1157	CDD:293787	27/27 (100%)
		HEAT repeat	1163..1193	CDD:293787	29/29 (100%)
		HEAT repeat	1204..1230	CDD:293787	20/25 (80%)
Sf3b1	NP_445878.1	CTD	241..382	CDD:215026	84/159 (53%)
		SF3b1	332..442	CDD:401026	59/109 (54%)
		HSH155	446..1304	CDD:227508	772/857 (90%)
		HEAT repeat	464..485	CDD:293787	11/20 (55%)
		HEAT repeat	497..524	CDD:293787	19/26 (73%)
		HEAT repeat	534..562	CDD:293787	24/27 (89%)
		HEAT repeat	573..599	CDD:293787	24/25 (96%)
		HEAT repeat	610..635	CDD:293787	22/24 (92%)
		HEAT repeat	850..874	CDD:293787	21/23 (91%)
		HEAT repeat	888..919	CDD:293787	27/30 (90%)
		HEAT repeat	931..964	CDD:293787	29/32 (91%)
		HEAT repeat	973..999	CDD:293787	24/25 (96%)
		HEAT repeat	1013..1042	CDD:293787	28/28 (100%)
		HEAT repeat	1054..1087	CDD:293787	31/32 (97%)
		HEAT repeat	1096..1118	CDD:293787	21/21 (100%)
		HEAT repeat	1129..1161	CDD:293787	30/31 (97%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350550
Domainoid	1	1.000	1354	1.000	Domainoid score	I6
eggNOG	1	0.900	-	-		E1_COG5181
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6696
Inparanoid	1	1.050	1950	1.000	Inparanoid score	I49
OMA	1	1.010	-	-		QHG53897
OrthoDB	1	1.010	-	-		D245208at2759
OrthoFinder	1	1.000	-	-		FOG0004708
OrthoInspector	1	1.000	-	-		oto96286
orthoMCL	1	0.900	-	-		OOG6_101702
Panther	1	1.100	-	-	LDO	PTHR12097
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3309
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770