DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sf3b1 and AT5G64270

DIOPT Version :9

Sequence 1:	NP_001259837.1	Gene:	Sf3b1 / 33235	FlyBaseID:	FBgn0031266	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_201232.1	Gene:	AT5G64270 / 836548	AraportID:	AT5G64270	Length:	1269	Species:	Arabidopsis thaliana

Alignment Length:	1354	Identity:	888/1354 - (65%)
Similarity:	1032/1354 - (76%)	Gaps:	118/1354 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DIEAQISVIQEKKTELAKTTAAAAGVGLLDSGGFFDSDLYDDDAAKGKGRYEGYNTSIAANDAEE 74
            |::.:|:..||::.::....|:...:       .||.|||      |......|:||||.|:.::
plant     3 DLDPEIAKTQEERRKMEADLASLTSL-------TFDRDLY------GGNDRASYSTSIAPNEEDD 54

  Fly    75 VDEDEDDGFPVPQKRTTYTAPASVLKDVTQGKEDVDPMADRRRPTIADREDEYRQKRRHIIISPE 139
            .:.| ..|..|.|:..:||||.|:|.||.:...:.|.:..:.|.:||:||.|||.:|.:.::||:
plant    55 ANLD-TTGSLVAQRLASYTAPRSILNDVARPHNEDDDVGFKPRQSIAEREGEYRNRRLNRVLSPD 118

  Fly   140 RADPFADGGKTPDVGSRTYTDIMREQMLKGEESELRRRILEKTKEGTLVKTVTSSSTSNGDLPAP 204
            |.|.||.|.||||...|||||.|||..|:.|:.|..|.|.:|.||    :...::.......|.|
plant   119 RVDAFAMGDKTPDASVRTYTDHMRETALQREKEETMRLIAKKKKE----EEEAAAKHQKDSAPPP 179

  Fly   205 -----KDGGRKRGRWDQTVSDSFIPAKMATPSSAATPTWE--DKTPGDHRWDETPGHKGSETPGA 262
                 ....::|.|||....|    ...|..:.||:..|:  |..||..|||       :.|||
plant   180 PASSSSSSSKRRHRWDLPEED----GAAAKKAKAASSDWDLPDAAPGIGRWD-------APTPG- 232

  Fly   263 TPGLGTRIWDATPAHAVTPGHETPGHEKSARRNRWDETPKTERETPGHSGWAETPKPDRTGSGG- 326
                  |:.||||:              :.|||||||||     |||     .....|.|..||
plant   233 ------RVSDATPS--------------AGRRNRWDETP-----TPG-----RVTDSDATPGGGV 267

  Fly   327 --GAESISIE----STPGASKRRSRWDETPSNATPAITPTNASAMTPNMTPSMTPHVTPGHATPM 385
              ||....:.    :||...::||||||||:                          |.|.||||
plant   268 TPGATPSGVTWDGLATPTPKRQRSRWDETPA--------------------------TMGSATPM 306

  Fly   386 --LTPG-----GSTPIGVKAMAMATPSAGAL---AAMTPEQLQAYRWEKEIDERNRPYTDEELDQ 440
              :|||     |.||||  .:.||||:.|.|   ..||||||...||||:|:|||||.:|||||.
plant   307 GGVTPGAAYTPGVTPIG--GIDMATPTPGQLIFRGPMTPEQLNMQRWEKDIEERNRPLSDEELDA 369

  Fly   441 IFP-PGYKILPPPAGYVPLRTPGRKLMATPTPIAGTPAGFFIQVEDKNAKFMDNQPK-GQNLPFM 503
            :|| .|||:|.|||.|||:|||.|||..||||:| || |:.|..|::..:: |..|: ...||||
plant   370 MFPKDGYKVLDPPATYVPIRTPARKLQQTPTPMA-TP-GYVIPEENRGQQY-DVPPEVPGGLPFM 431

  Fly   504 KPEDAQYFDKLLVDVNEDSLSPEELKERKIMKLLLTIKNGSPPMRKSALRQITDKAREFGAGPLF 568
            ||||.|||..||.:.||:.|||||.||||||||||.:|||:||.||:||||:||||||.||||||
plant   432 KPEDYQYFGSLLNEENEEELSPEEQKERKIMKLLLKVKNGTPPQRKTALRQLTDKARELGAGPLF 496

  Fly   569 NQILPLLMSPTLEDQERHLLVKVIDRVLYKLDDLVRPYVHKILVVIEPLLIDEDHYARIEGREII 633
            |:||||||.|||||||||||||||||:|||||::||||||||||||||||||||:|||:||||||
plant   497 NKILPLLMQPTLEDQERHLLVKVIDRILYKLDEMVRPYVHKILVVIEPLLIDEDYYARVEGREII 561

  Fly   634 SNLAKAAGLATMISTMRPDIDNIDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQARH 698
            |||:||||||:||:.||||||||||||||||||||:|||||||||:|||||||||:||:||||||
plant   562 SNLSKAAGLASMIAAMRPDIDNIDEYVRNTTARAFSVVASALGIPALLPFLKAVCQSKRSWQARH 626

  Fly   699 TGIKIVQQIAILMGCAILPHLKALVEIIEHGLVDEQQKVRTITALAIAALAEAATPYGIESFDSV 763
            ||||||||||||:|||:||||::|||||||||.||.|||||||||::|||||||.||||||||||
plant   627 TGIKIVQQIAILIGCAVLPHLRSLVEIIEHGLSDENQKVRTITALSLAALAEAAAPYGIESFDSV 691

  Fly   764 LKPLWKGIRTHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKKIVLKVV 828
            |||||||||:||||.|||||||||::||||||.||:|||:|||:|||||||||||||||||||||
plant   692 LKPLWKGIRSHRGKVLAAFLKAIGFIIPLMDAIYASYYTKEVMVILIREFQSPDEEMKKIVLKVV 756

  Fly   829 KQCCATDGVEPQYIKEEILPHFFKFFWNHRMALDRRNYRQLVDTTVEIANKVGASEIINRVVDDL 893
            |||.:|:||||:||:.:|||.||:.||..:|||:||||:|||:||||:|||||.::|:.|||:||
plant   757 KQCVSTEGVEPEYIRSDILPEFFRNFWTRKMALERRNYKQLVETTVEVANKVGVADIVGRVVEDL 821

  Fly   894 KDENEQYRKMVMETVEKIMGNLGAADIDSRLEEQLIDGILYAFQEQTTEDV-VMLNGFGTIVNQL 957
            |||:||||:|||||::|::.||||:|||:||||.|||||||||||||::|. |||||||.:||.|
plant   822 KDESEQYRRMVMETIDKVVTNLGASDIDARLEELLIDGILYAFQEQTSDDANVMLNGFGAVVNAL 886

  Fly   958 GKRVKPYLPQICGTILWRLNNKSAKVRQQAADLISRIAVVMKTCQEEKLMGHLGVVLYEYLGEEY 1022
            |:|||||||||||||.||||||||||||||||||||||||||.|.||:|||||||||||||||||
plant   887 GQRVKPYLPQICGTIKWRLNNKSAKVRQQAADLISRIAVVMKQCGEEQLMGHLGVVLYEYLGEEY 951

  Fly  1023 PEVLGSILGALKAIVNVIGMTKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGPEYVS 1087
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|:|.
plant   952 PEVLGSILGALKAIVNVIGMTKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAEFVP 1016

  Fly  1088 AREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTVAI 1152
            |||||||||||||:||||||.||||||||||||||||||.|||||||||||||||||||||||||
plant  1017 AREWMRICFELLEMLKAHKKGIRRATVNTFGYIAKAIGPQDVLATLLNNLKVQERQNRVCTTVAI 1081

  Fly  1153 AIVAESCRPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVCPLLEDALMDRD 1217
            |||||:|.|||||||||||||||||||||||||||||||||||||||||||||.|||||||||||
plant  1082 AIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDRD 1146

  Fly  1218 LVHRQTACSAIKHMSLGVYGFGCEDALTHLLNYVWPNIFETSPHLVQAFMDSVDGLRVSLGPIKI 1282
            |||||||.||:|||:|||.|.||||||.||||::||||||||||::.|.|::::|:||:||...|
plant  1147 LVHRQTAASAVKHMALGVAGLGCEDALVHLLNFIWPNIFETSPHVINAVMEAIEGMRVALGAAVI 1211

  Fly  1283 LQYTLQGLFHPARKVRDVYWKIYNSLYIGGQDALIAGYPRITNDPKNQYERYEL 1336
            |.|.||||||||||||:||||||||||||.||.|:|.||.:.::..|.|.|.||
plant  1212 LNYCLQGLFHPARKVREVYWKIYNSLYIGAQDTLVAAYPVLEDEQNNVYSRPEL 1265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sf3b1	NP_001259837.1	SF3b1	340..477	CDD:286064	73/147 (50%)
		HSH155	483..1340	CDD:227508	701/856 (82%)
		HEAT repeat	500..521	CDD:293787	14/20 (70%)
		HEAT repeat	533..560	CDD:293787	20/26 (77%)
		HEAT repeat	570..598	CDD:293787	24/27 (89%)
		HEAT repeat	609..635	CDD:293787	23/25 (92%)
		HEAT repeat	642..670	CDD:293787	24/27 (89%)
		HEAT repeat	680..709	CDD:293787	26/28 (93%)
		HEAT repeat	805..830	CDD:293787	23/24 (96%)
		HEAT repeat	886..910	CDD:293787	17/23 (74%)
		HEAT repeat	924..955	CDD:293787	24/31 (77%)
		HEAT_EZ	947..994	CDD:290247	41/46 (89%)
		HEAT repeat	967..1000	CDD:293787	31/32 (97%)
		HEAT repeat	1009..1035	CDD:293787	25/25 (100%)
		ARM	1016..1117	CDD:237987	95/100 (95%)
		HEAT repeat	1049..1078	CDD:293787	28/28 (100%)
		HEAT repeat	1098..1119	CDD:293787	18/20 (90%)
		HEAT repeat	1129..1157	CDD:293787	27/27 (100%)
		HEAT repeat	1163..1193	CDD:293787	29/29 (100%)
		HEAT repeat	1204..1230	CDD:293787	22/25 (88%)
AT5G64270	NP_201232.1	SF3b1	287..406	CDD:401026	74/148 (50%)
		HSH155	385..1262	CDD:227508	716/879 (81%)
		HEAT repeat	499..525	CDD:293787	23/25 (92%)
		HEAT repeat	537..567	CDD:293787	26/29 (90%)
		HEAT repeat	570..598	CDD:293787	24/27 (89%)
		HEAT repeat	608..637	CDD:293787	26/28 (93%)
		HEAT repeat	816..838	CDD:293787	17/21 (81%)
		HEAT repeat	852..888	CDD:293787	27/35 (77%)
		HEAT repeat	896..929	CDD:293787	31/32 (97%)
		HEAT repeat	938..964	CDD:293787	25/25 (100%)
		HEAT repeat	978..1007	CDD:293787	28/28 (100%)
		HEAT repeat	1027..1048	CDD:293787	18/20 (90%)
		HEAT repeat	1058..1086	CDD:293787	27/27 (100%)
		HEAT repeat	1092..1122	CDD:293787	29/29 (100%)
		HEAT repeat	1133..1159	CDD:293787	22/25 (88%)
		HEAT repeat	1173..1199	CDD:293787	17/25 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	931	1.000	Domainoid score	I1
eggNOG	1	0.900	-	-		E1_COG5181
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6696
Inparanoid	1	1.050	1621	1.000	Inparanoid score	I7
OMA	1	1.010	-	-		QHG53897
OrthoDB	1	1.010	-	-		D245208at2759
OrthoFinder	1	1.000	-	-		FOG0004708
OrthoInspector	1	1.000	-	-		oto3798
orthoMCL	1	0.900	-	-		OOG6_101702
Panther	1	1.100	-	-	LDO	PTHR12097
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3309
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840