back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sf3b1 and Sf3b1

DIOPT Version :9

Sequence 1:	NP_001259837.1	Gene:	Sf3b1 / 33235	FlyBaseID:	FBgn0031266	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_112456.2	Gene:	Sf3b1 / 81898	MGIID:	1932339	Length:	1304	Species:	Mus musculus

Alignment Length:	1363	Identity:	1044/1363 - (76%)
Similarity:	1139/1363 - (83%)	Gaps:	82/1363 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MENIPRTHEDIEAQISVIQEKKTELAKTTAAAAGVGLLDSGGFFDSDLYDDDAAKGKGRYEGYNT 65
            |..|.:|||||||||..||.||..|.:    |.||| |||.|::|.::|    .....|:.||.|
Mouse     1 MAKIAKTHEDIEAQIREIQGKKAALDE----AQGVG-LDSTGYYDQEIY----GGSDSRFAGYVT 56

  Fly    66 SIAANDAEEVDEDEDDGFP-VPQKRTTYTAPASVLKDVTQGKEDVDPMADRRRPTIADREDEYRQ 129
            ||||.:.|:.|:|...... :.||:..|.||.::|.|:.|..|..||.|:.|.|.||||||||::
Mouse    57 SIAATELEDDDDDYSSSTSLLGQKKPGYHAPVALLNDIPQSTEQYDPFAEHRPPKIADREDEYKK 121

  Fly   130 KRRHIIISPERADPFADGGKTPD--VGSRTYTDIMREQMLKGEESELRRRILEKTKEGTLVKTVT 192
            .||.:||||||.|||||||||||  :.:|||.|:||||.|..||.|:|:::.||.|.|.| |.|.
Mouse   122 HRRTMIISPERLDPFADGGKTPDPKMNARTYMDVMREQHLTKEEREIRQQLAEKAKAGEL-KVVN 185

  Fly   193 SSSTSNGDLPAPKDGGRKRGRWDQTVSDSFIPAKMATPSSAATPTWED-KTPGDH----RWDETP 252
            .::.|.   |..|   ||| |||||...:  |.  |||...:  :|:. :||| |    ||||||
Mouse   186 GAAASQ---PPSK---RKR-RWDQTADQT--PG--ATPKKLS--SWDQAETPG-HTPSLRWDETP 236

  Fly   253 GH-KGSETPGATPGLGTRIWDATPAHAV----------TPGHETPGH---EKSARRNRWDETPKT 303
            |. ||||||||||  |::|||.||:|..          ||||.||||   ..|||:|||||||||
Mouse   237 GRAKGSETPGATP--GSKIWDPTPSHTPAGAATPGRGDTPGHATPGHGGATSSARKNRWDETPKT 299

  Fly   304 ERETPGH-SGWAETPKPDRTGSGGGAESISIESTPGASKRRSRWDETPSNATPAITPTNASAMTP 367
            ||:|||| |||||||:.||     |.:||....|||||||:|||||||           ||.|
Mouse   300 ERDTPGHGSGWAETPRTDR-----GGDSIGETPTPGASKRKSRWDETP-----------ASQM-- 346

  Fly   368 NMTPSMTPHVTPGHATPMLTPGGSTPIGVKAMAMATPSAGALAAMTPEQLQAYRWEKEIDERNRP 432
                        |.:||:||| |.||||..||.||||:.|.:.:||||||||:|||:||||||||
Mouse   347 ------------GGSTPVLTP-GKTPIGTPAMNMATPTPGHIMSMTPEQLQAWRWEREIDERNRP 398

  Fly   433 YTDEELDQIFPPGYKILPPPAGYVPLRTPGRKLMATPTPIAGTPAGFFIQVEDKNAKFMDNQPKG 497
            .:|||||.:||.|||:|||||||||:|||.|||.|||||:.|. .||.:|.||:..|.:::||.|
Mouse   399 LSDEELDAMFPEGYKVLPPPAGYVPIRTPARKLTATPTPLGGM-TGFHMQTEDRTMKSVNDQPSG 462

  Fly   498 QNLPFMKPEDAQYFDKLLVDVNEDSLSPEELKERKIMKLLLTIKNGSPPMRKSALRQITDKAREF 562
             ||||:||:|.||||||||||:|.:|||||.||||||||||.||||:|||||:||||||||||||
Mouse   463 -NLPFLKPDDIQYFDKLLVDVDESTLSPEEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREF 526

  Fly   563 GAGPLFNQILPLLMSPTLEDQERHLLVKVIDRVLYKLDDLVRPYVHKILVVIEPLLIDEDHYARI 627
            ||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||:|||:
Mouse   527 GAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARV 591

  Fly   628 EGREIISNLAKAAGLATMISTMRPDIDNIDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKK 692
            ||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||
Mouse   592 EGREIISNLAKAAGLATMISTMRPDIDNMDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKK 656

  Fly   693 SWQARHTGIKIVQQIAILMGCAILPHLKALVEIIEHGLVDEQQKVRTITALAIAALAEAATPYGI 757
            |||||||||||||||||||||||||||::|||||||||||||||||||:||||||||||||||||
Mouse   657 SWQARHTGIKIVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAATPYGI 721

  Fly   758 ESFDSVLKPLWKGIRTHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKK 822
            |||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   722 ESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKK 786

  Fly   823 IVLKVVKQCCATDGVEPQYIKEEILPHFFKFFWNHRMALDRRNYRQLVDTTVEIANKVGASEIIN 887
            ||||||||||.|||||..|||.||||.|||.||.|||||||||||||||||||:||||||:|||:
Mouse   787 IVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVELANKVGAAEIIS 851

  Fly   888 RVVDDLKDENEQYRKMVMETVEKIMGNLGAADIDSRLEEQLIDGILYAFQEQTTEDVVMLNGFGT 952
            |:|||||||.||||||||||:|||||||||||||.:||||||||||||||||||||.||||||||
Mouse   852 RIVDDLKDEAEQYRKMVMETIEKIMGNLGAADIDHKLEEQLIDGILYAFQEQTTEDSVMLNGFGT 916

  Fly   953 IVNQLGKRVKPYLPQICGTILWRLNNKSAKVRQQAADLISRIAVVMKTCQEEKLMGHLGVVLYEY 1017
            :||.|||||||||||||||:|||||||||||||||||||||.|||||||||||||||||||||||
Mouse   917 VVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEY 981

  Fly  1018 LGEEYPEVLGSILGALKAIVNVIGMTKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRG 1082
            |||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||
Mouse   982 LGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRG 1046

  Fly  1083 PEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVC 1147
            .||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1047 AEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVC 1111

  Fly  1148 TTVAIAIVAESCRPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVCPLLEDA 1212
            ||||||||||:|.|||||||||||||||||||||||||||||||||||||||||||||.||||||
Mouse  1112 TTVAIAIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDA 1176

  Fly  1213 LMDRDLVHRQTACSAIKHMSLGVYGFGCEDALTHLLNYVWPNIFETSPHLVQAFMDSVDGLRVSL 1277
            ||||||||||||.:.::|||||||||||||:|.|||||||||:||||||::||.|.:::||||::
Mouse  1177 LMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLRVAI 1241

  Fly  1278 GPIKILQYTLQGLFHPARKVRDVYWKIYNSLYIGGQDALIAGYPRITNDPKNQYERYELDYTL 1340
            ||.::|||.|||||||||||||||||||||:|||.||||||.||||.||.||.|.||||||.|
Mouse  1242 GPCRMLQYCLQGLFHPARKVRDVYWKIYNSIYIGSQDALIAHYPRIYNDDKNTYIRYELDYIL 1304

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.