DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sf3b1 and sf3b1

DIOPT Version :10

Sequence 1:NP_608534.2 Gene:Sf3b1 / 33235 FlyBaseID:FBgn0031266 Length:1340 Species:Drosophila melanogaster
Sequence 2:XP_684311.1 Gene:sf3b1 / 446117 ZFINID:ZDB-GENE-040827-3 Length:1315 Species:Danio rerio


Alignment Length:1373 Identity:1032/1373 - (75%)
Similarity:1135/1373 - (82%) Gaps:91/1373 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MENIPRTHEDIEAQISVIQEKKTELAKTTAAAAGVGLLDSGGFFDSDLYDDDAAKGKGRYEGYNT 65
            |..|.:||:||||||..||.||..|. ......||| |||.|::|.::|    .....|::||.|
Zfish     1 MAQIAKTHDDIEAQILEIQGKKAALV-VEGGDQGVG-LDSTGYYDQEIY----GGSDSRFDGYLT 59

  Fly    66 SIAANDAEEVDEDEDDGFPVPQKRTTYTAPASVLKDVTQGKEDVDPMADRRRPTIADREDEYRQK 130
            |||||:.|:.|:::.....:.||:..|.||.::|..:.|..|..||.|:.|...|:||||||:::
Zfish    60 SIAANEQEDDDDEDSSTSLLVQKKPGYHAPVAILNSIPQSDEQYDPFAEHRPQKISDREDEYKKR 124

  Fly   131 RRHIIISPERADPFADGGKTPD--VGSRTYTDIMREQMLKGEESELRRRILEKTKEGTLVKTVTS 193
            |:.:||||||.|||||||||||  |..|||.|:|:||.|..||.|:|.:::||.|.|.| |.|..
Zfish   125 RQKMIISPERHDPFADGGKTPDPKVQVRTYMDVMKEQQLSKEEREIRLQMVEKAKAGEL-KAVNG 188

  Fly   194 SSTSNGDLPAPKDGGRKRGRWDQTVSDSFIPAKMATPSSAATP----TWED-------------K 241
            |:.|..       ..:::.|||||...        |||: :||    :|:.             .
Zfish   189 SAASQA-------AAKRKRRWDQTADQ--------TPSN-STPKKVSSWDQADGGSETPGHTPGH 237

  Fly   242 TPGDHRWDETPGH-KGSETPGATPGLGTRIWDATPAH----AVTPGHETPGH--------EKSAR 293
            ||.:.|||||||. ||||||||||  .||:|:.||:|    |.|||.:||||        ..|.|
Zfish   238 TPSNSRWDETPGRPKGSETPGATP--STRMWEPTPSHTPAGAATPGRDTPGHATPGHGGATSSVR 300

  Fly   294 RNRWDETPKTERETPGH-SGWAETPKPDRTGSGGGAESISIESTPGASKRRSRWDETPSNATPAI 357
            :|||||||||||||||| |||||||:.||     |.||:....|||||||:|||||||       
Zfish   301 KNRWDETPKTERETPGHGSGWAETPRTDR-----GDESVGETPTPGASKRKSRWDETP------- 353

  Fly   358 TPTNASAMTPNMTPSMTPHVTPGHATPMLTPGGSTPIGVKAMAMATPSAGALAAMTPEQLQAYRW 422
                ||.|              |.:||:||| |.||:|..||.||||:.|.|.:||||||||:||
Zfish   354 ----ASQM--------------GSSTPLLTP-GKTPLGTPAMNMATPTPGHLMSMTPEQLQAWRW 399

  Fly   423 EKEIDERNRPYTDEELDQIFPPGYKILPPPAGYVPLRTPGRKLMATPTPIAGTPAGFFIQVEDKN 487
            |:||||||||.||||||.:||.|||:|||||||||:|||.|||.||||||.|. .||.:|.||::
Zfish   400 EREIDERNRPLTDEELDAMFPEGYKVLPPPAGYVPIRTPARKLAATPTPIGGM-TGFHMQTEDRS 463

  Fly   488 AKFMDNQPKGQNLPFMKPEDAQYFDKLLVDVNEDSLSPEELKERKIMKLLLTIKNGSPPMRKSAL 552
            .|.:::||.| ||||:||:|.||||||||:|:|.:|||||.||||||||||.||||:|||||:||
Zfish   464 MKQVNDQPSG-NLPFLKPDDIQYFDKLLVEVDESTLSPEEQKERKIMKLLLKIKNGTPPMRKAAL 527

  Fly   553 RQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRVLYKLDDLVRPYVHKILVVIEPL 617
            ||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||
Zfish   528 RQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPL 592

  Fly   618 LIDEDHYARIEGREIISNLAKAAGLATMISTMRPDIDNIDEYVRNTTARAFAVVASALGIPSLLP 682
            |||||:|||:||||||||||||||||||||||||||||:||||||||||||||||||||||||||
Zfish   593 LIDEDYYARVEGREIISNLAKAAGLATMISTMRPDIDNMDEYVRNTTARAFAVVASALGIPSLLP 657

  Fly   683 FLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLKALVEIIEHGLVDEQQKVRTITALAIAA 747
            |||||||||||||||||||||||||||||||||||||::|||||||||||||||||||:||||||
Zfish   658 FLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAA 722

  Fly   748 LAEAATPYGIESFDSVLKPLWKGIRTHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIRE 812
            |||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||
Zfish   723 LAEAATPYGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIRE 787

  Fly   813 FQSPDEEMKKIVLKVVKQCCATDGVEPQYIKEEILPHFFKFFWNHRMALDRRNYRQLVDTTVEIA 877
            ||||||||||||||||||||||||||..|||.||||.|||.||.|||||||||||||||||||:|
Zfish   788 FQSPDEEMKKIVLKVVKQCCATDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVELA 852

  Fly   878 NKVGASEIINRVVDDLKDENEQYRKMVMETVEKIMGNLGAADIDSRLEEQLIDGILYAFQEQTTE 942
            |||||:|||:|:|||||||.||||||||||:|||||||||||||.:|||||||||||||||||||
Zfish   853 NKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADIDHKLEEQLIDGILYAFQEQTTE 917

  Fly   943 DVVMLNGFGTIVNQLGKRVKPYLPQICGTILWRLNNKSAKVRQQAADLISRIAVVMKTCQEEKLM 1007
            |.||||||||:||.|||||||||||||||:|||||||||||||||||||||.|||||||||||||
Zfish   918 DSVMLNGFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLM 982

  Fly  1008 GHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMTKMTPPIKDLLPRLTPILKNRHEKVQENCI 1072
            |||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||
Zfish   983 GHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCI 1047

  Fly  1073 DLVGRIADRGPEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNL 1137
            ||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish  1048 DLVGRIADRGAEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNL 1112

  Fly  1138 KVQERQNRVCTTVAIAIVAESCRPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYI 1202
            ||||||||||||||||||||:|.||||||||||||||||||||||||||||||||||||||||||
Zfish  1113 KVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYI 1177

  Fly  1203 YAVCPLLEDALMDRDLVHRQTACSAIKHMSLGVYGFGCEDALTHLLNYVWPNIFETSPHLVQAFM 1267
            |||.||||||||||||||||||.:.::|||||||||||||:|.|||||||||:||||||::||.|
Zfish  1178 YAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVM 1242

  Fly  1268 DSVDGLRVSLGPIKILQYTLQGLFHPARKVRDVYWKIYNSLYIGGQDALIAGYPRITNDPKNQYE 1332
            .:::||||::||.::|||.|||||||||||||||||||||:|||.||||||.||.|.||.||.|.
Zfish  1243 GALEGLRVAIGPCRMLQYCLQGLFHPARKVRDVYWKIYNSIYIGSQDALIAHYPLIFNDEKNSYV 1307

  Fly  1333 RYELDYTL 1340
            ||||:|.|
Zfish  1308 RYELEYFL 1315

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sf3b1NP_608534.2 PHA03247 <200..477 CDD:223021 161/307 (52%)
SF3b1 340..476 CDD:462634 83/135 (61%)
HSH155 483..1340 CDD:227508 773/856 (90%)
HEAT repeat 642..670 CDD:293787 26/27 (96%)
HEAT repeat 680..709 CDD:293787 28/28 (100%)
HEAT repeat 886..910 CDD:293787 19/23 (83%)
HEAT repeat 924..955 CDD:293787 28/30 (93%)
HEAT repeat 967..1000 CDD:293787 30/32 (94%)
HEAT repeat 1009..1035 CDD:293787 25/25 (100%)
HEAT repeat 1049..1078 CDD:293787 28/28 (100%)
HEAT repeat 1098..1119 CDD:293787 20/20 (100%)
HEAT repeat 1129..1157 CDD:293787 27/27 (100%)
HEAT repeat 1163..1193 CDD:293787 29/29 (100%)
HEAT repeat 1204..1230 CDD:293787 20/25 (80%)
sf3b1XP_684311.1 PHA03307 188..>383 CDD:223039 109/243 (45%)
SF3b1 343..453 CDD:462634 83/136 (61%)
HSH155 457..1312 CDD:227508 772/855 (90%)
HEAT repeat 475..496 CDD:293787 15/20 (75%)
HEAT repeat 508..535 CDD:293787 23/26 (88%)
HEAT repeat 545..573 CDD:293787 26/27 (96%)
HEAT repeat 584..610 CDD:293787 23/25 (92%)
HEAT repeat 621..646 CDD:293787 23/24 (96%)
HEAT repeat 861..885 CDD:293787 19/23 (83%)
HEAT repeat 899..930 CDD:293787 28/30 (93%)
HEAT repeat 942..975 CDD:293787 30/32 (94%)
HEAT repeat 984..1010 CDD:293787 25/25 (100%)
HEAT repeat 1024..1053 CDD:293787 28/28 (100%)
HEAT repeat 1065..1098 CDD:293787 32/32 (100%)
HEAT repeat 1107..1129 CDD:293787 21/21 (100%)
HEAT repeat 1140..1172 CDD:293787 31/31 (100%)

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