DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sf3b1 and prp10

DIOPT Version :9

Sequence 1:	NP_001259837.1	Gene:	Sf3b1 / 33235	FlyBaseID:	FBgn0031266	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_594538.2	Gene:	prp10 / 2541619	PomBaseID:	SPAC27F1.09c	Length:	1166	Species:	Schizosaccharomyces pombe

Alignment Length:	1352	Identity:	694/1352 - (51%)
Similarity:	883/1352 - (65%)	Gaps:	222/1352 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 THEDIE-----AQISVIQEKKTELAKTTAAAAGVGLLDSGGFFDSDLYDDDAAKGKGRYEGYNTS 66
            |.||:|     |:..:::.:| |.||.::....|.:                       |.|:::
pombe     3 TVEDVEIERLRAERELLRRQK-EAAKNSSTNGSVNI-----------------------EEYDSA 43

  Fly    67 IAANDAEEVDEDEDDGFPVPQKRTT-----------YTAPASVLKDVTQGKEDVDPMADRR-RPT 119
            |...:  ::.:||||     .|||.           |.||..:|.:...  |..|||.:|: :..
pombe    44 IDVRN--DISQDEDD-----YKRTNDVNDSYRLVRQYEAPKELLNEYAD--ESYDPMQERQSKKQ 99

  Fly   120 IADREDEYRQKRRHIIISPERADPFADGGKTPDVGSRTYTDIMREQMLKGEESELRRRILEKTKE 184
            |.|||.:|:::|....::|.|.|.|...|...:  .|:|.::||:..|:.||..:...:.::.:|
pombe   100 IQDRESDYQKQRYDRQLTPTRVDAFQPDGTQSN--GRSYAEVMRQVELEKEERRVHMELNQRRRE 162

  Fly   185 GTLVKTVTSSSTSNGDLPAPKDGGRKRGRWDQTVSDSFIPAKMATPSSAATPTWEDKTPGDHRWD 249
            |||                      |....::::||.                        .|..
pombe   163 GTL----------------------KEVEEEESISDK------------------------KREL 181

  Fly   250 ETPGHKGSETPGATPGLGTRIWDATPAHAVTPGHETPGHEKSARRNRWDETPKTERETPGHSGWA 314
            |....:.|:.|                                :|:|||:.|
pombe   182 ELNNTEISQKP--------------------------------KRSRWDQAP------------- 201

  Fly   315 ETPKPDRTGSGGGAESISIESTPGASKRRSRWDETPSNATPAITPTNASAMTPNMTPSMTPHVTP 379
                          .|::..||   :|||||||:.|.|.|                  ::.||..
pombe   202 --------------PSVTQVST---TKRRSRWDKAPENFT------------------ISEHVIE 231

  Fly   380 GHATPMLTPGGSTPIGVKAMAMATPSAGALAAMTPEQLQAYRWEKE---IDERNRP----YTDEE 437
            ...:..|.                                   .||   ::|:.||    .|:||
pombe   232 NGISEDLI-----------------------------------NKEVNVVEEKLRPPVRLLTEEE 261

  Fly   438 LDQIFP-PGYKILPPPAGYVPLRTPGRKLMATPTPIAGTPAGFFIQVEDKNAKFMDNQ-PKGQNL 500
            |:::.| .||.||.||.||:....|......|.......|....:.:|.:....:..: |...:|
pombe   262 LNELLPSEGYAILEPPPGYLESIHPELLQKGTTLDTYHVPQEQELPLEKELPAALPTEIPGVGDL 326

  Fly   501 PFMKPEDAQYFDKLLVDVNEDSLSPEELKERKIMKLLLTIKNGSPPMRKSALRQITDKAREFGAG 565
            .|.|.||.:||.|||...:|..|:..||:||||::|||.:|||:||||||||||:||:||:|||.
pombe   327 AFFKQEDVKYFGKLLKVEDEAKLTIAELRERKILRLLLKVKNGTPPMRKSALRQLTDQARDFGAA 391

  Fly   566 PLFNQILPLLMSPTLEDQERHLLVKVIDRVLYKLDDLVRPYVHKILVVIEPLLIDEDHYARIEGR 630
            .||||||||||..||||||||||||||||:||||||||||:.|||||||||||||||:|||.|||
pombe   392 ALFNQILPLLMERTLEDQERHLLVKVIDRILYKLDDLVRPFTHKILVVIEPLLIDEDYYARAEGR 456

  Fly   631 EIISNLAKAAGLATMISTMRPDIDNIDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQ 695
            |||||||||:|||.||:|||||||::||||||||||||:|||||||:|:|||||||||:||||||
pombe   457 EIISNLAKASGLAHMIATMRPDIDHVDEYVRNTTARAFSVVASALGVPALLPFLKAVCRSKKSWQ 521

  Fly   696 ARHTGIKIVQQIAILMGCAILPHLKALVEIIEHGLVDEQQKVRTITALAIAALAEAATPYGIESF 760
            |||||::|:||||:|:||:||||||.||:.|.|||.|||||||.:|||:::||||||||||||:|
pombe   522 ARHTGVRIIQQIALLLGCSILPHLKNLVDCIGHGLEDEQQKVRIMTALSLSALAEAATPYGIEAF 586

  Fly   761 DSVLKPLWKGIRTHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKKIVL 825
            ||||||||.|::.||||.|||||||.|::||||:.|||:::||.:|.||:|||.|||||||||||
pombe   587 DSVLKPLWSGVQRHRGKSLAAFLKATGFIIPLMEPEYASHFTRRIMKILLREFNSPDEEMKKIVL 651

  Fly   826 KVVKQCCATDGVEPQYIKEEILPHFFKFFWNHRMALDRRNYRQLVDTTVEIANKVGASEIINRVV 890
            |||.||.:||||.|:|::.::||.||..||:.|||.|||:|:|:|:|||.:|.:||:.:|:.|||
pombe   652 KVVSQCASTDGVTPEYLRTDVLPEFFHCFWSRRMASDRRSYKQVVETTVVLAQQVGSRQIVERVV 716

  Fly   891 DDLKDENEQYRKMVMETVEKIMGNLGAADIDSRLEEQLIDGILYAFQEQTTEDVVMLNGFGTIVN 955
            ::.|||:|.||||..|||:|::|:||.::||.||||.|:||:|:|||||:.|:.|:|..|.|:||
pombe   717 NNFKDESEPYRKMTAETVDKVIGSLGVSEIDERLEELLLDGVLFAFQEQSVEEKVILTCFSTVVN 781

  Fly   956 QLGKRVKPYLPQICGTILWRLNNKSAKVRQQAADLISRIAVVMKTCQEEKLMGHLGVVLYEYLGE 1020
            .||.|.|||||||..|||:|||||||.||:|||||:|.|.:|:|.|.||.||..|||||||||||
pombe   782 ALGTRCKPYLPQIVSTILYRLNNKSANVREQAADLVSSITIVLKACGEEALMRKLGVVLYEYLGE 846

  Fly  1021 EYPEVLGSILGALKAIVNVIGMTKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGPEY 1085
            ||||||||||||:||||:|:||:.|.|||:||||||||||:|||||||||.|||||:|||||.||
pombe   847 EYPEVLGSILGAIKAIVSVVGMSSMQPPIRDLLPRLTPILRNRHEKVQENTIDLVGKIADRGSEY 911

  Fly  1086 VSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTV 1150
            |||||||||||||:::||||||:||||.|||||||:|||||.|||||||||||||||||||||||
pombe   912 VSAREWMRICFELIDMLKAHKKSIRRAAVNTFGYISKAIGPQDVLATLLNNLKVQERQNRVCTTV 976

  Fly  1151 AIAIVAESCRPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVCPLLEDALMD 1215
            |||||||:|.||||:||||.:||.||:||||||||||:|:||||||..:||:||:.|||.|||||
pombe   977 AIAIVAETCMPFTVVPALMADYRTPEMNVQNGVLKSLAFMFEYIGEQARDYVYAITPLLADALMD 1041

  Fly  1216 RDLVHRQTACSAIKHMSLGVYGFGCEDALTHLLNYVWPNIFETSPHLVQAFMDSVDGLRVSLGPI 1280
            ||.||||||.|.|||:|||..|.|.|||:.||||.:||||.|.|||::.|..:.:||:|..:|..
pombe  1042 RDAVHRQTAASVIKHLSLGCVGLGVEDAMIHLLNILWPNILEESPHVINAVREGIDGIRNCIGVG 1106

  Fly  1281 KILQYTLQGLFHPARKVRDVYWKIYNSLYIGGQDALIAGYPRITNDPKNQYE 1332
            .|:.|.:||||||:||||:.||..|||.|:...||::..||.:.:|..|.|:
pombe  1107 PIMAYLVQGLFHPSRKVRNTYWTSYNSAYVQSADAMVPYYPHVDDDQFNNYD 1158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sf3b1	NP_001259837.1	SF3b1	340..477	CDD:286064	33/144 (23%)
		HSH155	483..1340	CDD:227508	594/851 (70%)
		HEAT repeat	500..521	CDD:293787	10/20 (50%)
		HEAT repeat	533..560	CDD:293787	19/26 (73%)
		HEAT repeat	570..598	CDD:293787	24/27 (89%)
		HEAT repeat	609..635	CDD:293787	23/25 (92%)
		HEAT repeat	642..670	CDD:293787	23/27 (85%)
		HEAT repeat	680..709	CDD:293787	24/28 (86%)
		HEAT repeat	805..830	CDD:293787	20/24 (83%)
		HEAT repeat	886..910	CDD:293787	14/23 (61%)
		HEAT repeat	924..955	CDD:293787	17/30 (57%)
		HEAT_EZ	947..994	CDD:290247	33/46 (72%)
		HEAT repeat	967..1000	CDD:293787	22/32 (69%)
		HEAT repeat	1009..1035	CDD:293787	23/25 (92%)
		ARM	1016..1117	CDD:237987	84/100 (84%)
		HEAT repeat	1049..1078	CDD:293787	25/28 (89%)
		HEAT repeat	1098..1119	CDD:293787	15/20 (75%)
		HEAT repeat	1129..1157	CDD:293787	27/27 (100%)
		HEAT repeat	1163..1193	CDD:293787	22/29 (76%)
		HEAT repeat	1204..1230	CDD:293787	19/25 (76%)
prp10	NP_594538.2	HSH155	34..1166	CDD:227508	685/1320 (52%)
		HEAT repeat	398..424	CDD:293787	22/25 (88%)
		HEAT repeat	436..464	CDD:293787	25/27 (93%)
		HEAT repeat	506..535	CDD:293787	24/28 (86%)
		HEAT repeat	547..577	CDD:293787	19/29 (66%)
		HEAT repeat	586..614	CDD:293787	21/27 (78%)
		HEAT repeat	625..656	CDD:293787	22/30 (73%)
		HEAT repeat	672..697	CDD:293787	14/24 (58%)
		HEAT repeat	712..736	CDD:293787	14/23 (61%)
		HEAT repeat	754..788	CDD:293787	19/33 (58%)
		DUF3385	<770..818	CDD:288698	33/47 (70%)
		HEAT repeat	793..826	CDD:293787	22/32 (69%)
		HEAT repeat	835..861	CDD:293787	23/25 (92%)
		HEAT_EZ	849..904	CDD:290247	45/54 (83%)
		HEAT repeat	875..904	CDD:293787	25/28 (89%)
		HEAT repeat	916..949	CDD:293787	26/32 (81%)
		HEAT repeat	958..980	CDD:293787	21/21 (100%)
		HEAT repeat	987..1016	CDD:293787	22/28 (79%)
		HEAT repeat	1030..1056	CDD:293787	19/25 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	935	1.000	Domainoid score	I1
eggNOG	1	0.900	-	-		E1_COG5181
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6696
Inparanoid	1	1.050	1259	1.000	Inparanoid score	I15
OMA	1	1.010	-	-		QHG53897
OrthoFinder	1	1.000	-	-		FOG0004708
OrthoInspector	1	1.000	-	-		oto100843
orthoMCL	1	0.900	-	-		OOG6_101702
Panther	1	1.100	-	-	LDO	PTHR12097
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1324
SonicParanoid	1	1.000	-	-		X3309
TreeFam	1	0.960	-	-
	14	13.860