back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sf3b1 and SF3B1

DIOPT Version :9

Sequence 1:	NP_001259837.1	Gene:	Sf3b1 / 33235	FlyBaseID:	FBgn0031266	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_036565.2	Gene:	SF3B1 / 23451	HGNCID:	10768	Length:	1304	Species:	Homo sapiens

Alignment Length:	1367	Identity:	1045/1367 - (76%)
Similarity:	1138/1367 - (83%)	Gaps:	90/1367 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MENIPRTHEDIEAQISVIQEKKTELAKTTAAAAGVGLLDSGGFFDSDLYDDDAAKGKGRYEGYNT 65
            |..|.:|||||||||..||.||..|.:    |.||| |||.|::|.::|    .....|:.||.|
Human     1 MAKIAKTHEDIEAQIREIQGKKAALDE----AQGVG-LDSTGYYDQEIY----GGSDSRFAGYVT 56

  Fly    66 SIAANDAEEVDEDEDDGFP-VPQKRTTYTAPASVLKDVTQGKEDVDPMADRRRPTIADREDEYRQ 129
            ||||.:.|:.|:|...... :.||:..|.||.::|.|:.|..|..||.|:.|.|.||||||||::
Human    57 SIAATELEDDDDDYSSSTSLLGQKKPGYHAPVALLNDIPQSTEQYDPFAEHRPPKIADREDEYKK 121

  Fly   130 KRRHIIISPERADPFADGGKTPD--VGSRTYTDIMREQMLKGEESELRRRILEKTKEGTLVKTVT 192
            .||.:||||||.|||||||||||  :.:|||.|:||||.|..||.|:|:::.||.|.|.| |.|.
Human   122 HRRTMIISPERLDPFADGGKTPDPKMNARTYMDVMREQHLTKEEREIRQQLAEKAKAGEL-KVVN 185

  Fly   193 SSSTSNGDLPAPKDGGRKRGRWDQTVSDSFIPAKMATPSSAATP----TWED-KTPGDH----RW 248
            .::.|.   |..|   ||| |||||...        ||  .|||    :|:. :||| |    ||
Human   186 GAAASQ---PPSK---RKR-RWDQTADQ--------TP--GATPKKLSSWDQAETPG-HTPSLRW 232

  Fly   249 DETPGH-KGSETPGATPGLGTRIWDATPAHAV----------TPGHETPGH---EKSARRNRWDE 299
            |||||. ||||||||||  |::|||.||:|..          ||||.||||   ..|||:|||||
Human   233 DETPGRAKGSETPGATP--GSKIWDPTPSHTPAGAATPGRGDTPGHATPGHGGATSSARKNRWDE 295

  Fly   300 TPKTERETPGH-SGWAETPKPDRTGSGGGAESISIESTPGASKRRSRWDETPSNATPAITPTNAS 363
            ||||||:|||| |||||||:.||     |.:||....|||||||:|||||||           ||
Human   296 TPKTERDTPGHGSGWAETPRTDR-----GGDSIGETPTPGASKRKSRWDETP-----------AS 344

  Fly   364 AMTPNMTPSMTPHVTPGHATPMLTPGGSTPIGVKAMAMATPSAGALAAMTPEQLQAYRWEKEIDE 428
            .|              |.:||:||| |.||||..||.||||:.|.:.:||||||||:|||:||||
Human   345 QM--------------GGSTPVLTP-GKTPIGTPAMNMATPTPGHIMSMTPEQLQAWRWEREIDE 394

  Fly   429 RNRPYTDEELDQIFPPGYKILPPPAGYVPLRTPGRKLMATPTPIAGTPAGFFIQVEDKNAKFMDN 493
            ||||.:|||||.:||.|||:|||||||||:|||.|||.|||||:.|. .||.:|.||:..|.:::
Human   395 RNRPLSDEELDAMFPEGYKVLPPPAGYVPIRTPARKLTATPTPLGGM-TGFHMQTEDRTMKSVND 458

  Fly   494 QPKGQNLPFMKPEDAQYFDKLLVDVNEDSLSPEELKERKIMKLLLTIKNGSPPMRKSALRQITDK 558
            ||.| ||||:||:|.||||||||||:|.:|||||.||||||||||.||||:|||||:||||||||
Human   459 QPSG-NLPFLKPDDIQYFDKLLVDVDESTLSPEEQKERKIMKLLLKIKNGTPPMRKAALRQITDK 522

  Fly   559 AREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRVLYKLDDLVRPYVHKILVVIEPLLIDEDH 623
            ||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||:
Human   523 AREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDY 587

  Fly   624 YARIEGREIISNLAKAAGLATMISTMRPDIDNIDEYVRNTTARAFAVVASALGIPSLLPFLKAVC 688
            |||:||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||
Human   588 YARVEGREIISNLAKAAGLATMISTMRPDIDNMDEYVRNTTARAFAVVASALGIPSLLPFLKAVC 652

  Fly   689 KSKKSWQARHTGIKIVQQIAILMGCAILPHLKALVEIIEHGLVDEQQKVRTITALAIAALAEAAT 753
            |||||||||||||||||||||||||||||||::|||||||||||||||||||:||||||||||||
Human   653 KSKKSWQARHTGIKIVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAAT 717

  Fly   754 PYGIESFDSVLKPLWKGIRTHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDE 818
            |||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||
Human   718 PYGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDE 782

  Fly   819 EMKKIVLKVVKQCCATDGVEPQYIKEEILPHFFKFFWNHRMALDRRNYRQLVDTTVEIANKVGAS 883
            ||||||||||||||.|||||..|||.||||.|||.||.|||||||||||||||||||:||||||:
Human   783 EMKKIVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVELANKVGAA 847

  Fly   884 EIINRVVDDLKDENEQYRKMVMETVEKIMGNLGAADIDSRLEEQLIDGILYAFQEQTTEDVVMLN 948
            |||:|:|||||||.||||||||||:|||||||||||||.:||||||||||||||||||||.||||
Human   848 EIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADIDHKLEEQLIDGILYAFQEQTTEDSVMLN 912

  Fly   949 GFGTIVNQLGKRVKPYLPQICGTILWRLNNKSAKVRQQAADLISRIAVVMKTCQEEKLMGHLGVV 1013
            ||||:||.|||||||||||||||:|||||||||||||||||||||.|||||||||||||||||||
Human   913 GFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVV 977

  Fly  1014 LYEYLGEEYPEVLGSILGALKAIVNVIGMTKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRI 1078
            |||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||
Human   978 LYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRI 1042

  Fly  1079 ADRGPEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQ 1143
            ||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Human  1043 ADRGAEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQ 1107

  Fly  1144 NRVCTTVAIAIVAESCRPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVCPL 1208
            ||||||||||||||:|.|||||||||||||||||||||||||||||||||||||||||||||.||
Human  1108 NRVCTTVAIAIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPL 1172

  Fly  1209 LEDALMDRDLVHRQTACSAIKHMSLGVYGFGCEDALTHLLNYVWPNIFETSPHLVQAFMDSVDGL 1273
            ||||||||||||||||.:.::|||||||||||||:|.|||||||||:||||||::||.|.:::||
Human  1173 LEDALMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGL 1237

  Fly  1274 RVSLGPIKILQYTLQGLFHPARKVRDVYWKIYNSLYIGGQDALIAGYPRITNDPKNQYERYELDY 1338
            ||::||.::|||.|||||||||||||||||||||:|||.||||||.||||.||.||.|.||||||
Human  1238 RVAIGPCRMLQYCLQGLFHPARKVRDVYWKIYNSIYIGSQDALIAHYPRIYNDDKNTYIRYELDY 1302

  Fly  1339 TL 1340
            .|
Human  1303 IL 1304

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.