DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sf3b1 and sftb-1

DIOPT Version :9

Sequence 1:NP_001259837.1 Gene:Sf3b1 / 33235 FlyBaseID:FBgn0031266 Length:1340 Species:Drosophila melanogaster
Sequence 2:NP_497853.1 Gene:sftb-1 / 175549 WormBaseID:WBGene00011605 Length:1322 Species:Caenorhabditis elegans


Alignment Length:1374 Identity:912/1374 - (66%)
Similarity:1051/1374 - (76%) Gaps:102/1374 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 EAQISVIQEKKTELAKTTAAAA-------GVG---LLDSGGFFDSDLYDDDAAKGKGRYEGYNTS 66
            ||....:..|:  :|...||||       |.|   ...:.|.||:|:|  .:.:|:.| :.|..|
 Worm     6 EAYAQELNRKR--VANQRAAAAEDNDENKGNGNKVAFGAAGNFDTDVY--GSVRGENR-DSYLDS 65

  Fly    67 IAANDAEEVDEDEDDGFPVPQKRTT-YTAPASVLKDVTQGKEDVDPMADRRRPTIADREDEYRQK 130
            |...:.::|||   |..|..||::| |..|...:::|....||.||.||.|..|||:|:.:|.::
 Worm    66 IGTGEEDDVDE---DSMPSVQKKSTNYAQPHKFIEEVAAASEDTDPFADTRTKTIAERQSKYHER 127

  Fly   131 RRHIIISPERADPFADGGKTPDVGSRTYTDIMREQMLKGEESELRRRILEKTKEGTLVKTVTSSS 195
            .....|||:|||.|.|  :|||..:|.|.::||:||...|:..:.|.:.::.|.|.|  .||.. 
 Worm   128 AMRRQISPDRADAFVD--QTPDNRNRGYAEVMRDQMYHEEKGRVERELADRAKAGEL--HVTGQ- 187

  Fly   196 TSNGDLPAPKDGGRKRGRWD-----QTVSDSFIPAKMATPSSAATP---------TWEDKTPGDH 246
                    |:   :|:||||     ...|...:.|..||||..:.|         :.:..||...
 Worm   188 --------PE---KKKGRWDAEAPSTDASSDNLGAASATPSQGSAPRKRLGFSKISADAATPRAA 241

  Fly   247 RWDETPGHKGSETPGATPGLGTRIWDATPA---HAVTPGHETPGHEKSARRNRWDETPKTERE-- 306
            ||||||.|    :.||.        ||||:   .:.||..:||      ||||||||||....  
 Worm   242 RWDETPAH----STGAA--------DATPSVDKWSTTPAAQTP------RRNRWDETPKENLNDG 288

  Fly   307 --TPGHSGWA-ETPKPDRTGSGGGAESISIESTPGASKRRSRWDETPSNATP---AITPTNASAM 365
              ||   ||. |||      :.||::.:.||.||.|||||||||.|||. ||   |.||.::...
 Worm   289 SMTP---GWGMETP------ARGGSDDVKIEDTPSASKRRSRWDLTPSQ-TPNVAAATPLHSGLQ 343

  Fly   366 TPNMTPSMTPHVTPGHATPMLTPGGSTPIGVKAMAMATPSAGALAAMTPEQLQAYRWEKEIDERN 430
            ||:.||| .|..||..|   :||||:||||..||.|.|| |..:..|||||:|.||||||||:||
 Worm   344 TPSFTPS-HPSQTPIGA---MTPGGATPIGTAAMGMKTP-APHMIPMTPEQMQIYRWEKEIDDRN 403

  Fly   431 RPYTDEELDQIFPPGYKILPPPAGYVPLRTPGRKLMATPTPIAGTPAGFFIQ--------VEDKN 487
            ||.||||||.:||||||:|.||..|:|||||.|||||||||:.|...|.|..        :.:|.
 Worm   404 RPLTDEELDSLFPPGYKVLVPPMNYIPLRTPSRKLMATPTPMGGAAGGGFFMPGTPDRDGIGEKG 468

  Fly   488 -AKFMDNQPKGQNLPFMKPEDAQYFDKLLVDVNEDSLSPEELKERKIMKLLLTIKNGSPPMRKSA 551
             ...:|.|||...||.:||:|.|||||||:||:|..|:.||..||:||:.||.||||:||||||.
 Worm   469 VGGLVDTQPKNAELPPLKPDDMQYFDKLLMDVDESQLTKEEKNEREIMEHLLKIKNGTPPMRKSG 533

  Fly   552 LRQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRVLYKLDDLVRPYVHKILVVIEP 616
            ||:||:.||::||||||||||||||||:||||||||:||||||:|||||||||||||||||||||
 Worm   534 LRKITENARKYGAGPLFNQILPLLMSPSLEDQERHLMVKVIDRILYKLDDLVRPYVHKILVVIEP 598

  Fly   617 LLIDEDHYARIEGREIISNLAKAAGLATMISTMRPDIDNIDEYVRNTTARAFAVVASALGIPSLL 681
            ||||||:|||:||||||||||||||||||||||||||||:||||||||||||||||||||||:||
 Worm   599 LLIDEDYYARVEGREIISNLAKAAGLATMISTMRPDIDNVDEYVRNTTARAFAVVASALGIPALL 663

  Fly   682 PFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLKALVEIIEHGLVDEQQKVRTITALAIA 746
            |||||||||||||||||||||||||:|||||||:||||||||:|:|.||.||||||||||||.:|
 Worm   664 PFLKAVCKSKKSWQARHTGIKIVQQMAILMGCAVLPHLKALVDIVESGLDDEQQKVRTITALCLA 728

  Fly   747 ALAEAATPYGIESFDSVLKPLWKGIRTHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIR 811
            |||||::|||||:|||||||||||||.|||||||||||||||||||||||||:||||||||||||
 Worm   729 ALAEASSPYGIEAFDSVLKPLWKGIRMHRGKGLAAFLKAIGYLIPLMDAEYASYYTREVMLILIR 793

  Fly   812 EFQSPDEEMKKIVLKVVKQCCATDGVEPQYIKEEILPHFFKFFWNHRMALDRRNYRQLVDTTVEI 876
            ||.||||||||||||||||||||||||..||::|:||.|||.|||.|||:|||||||||||||||
 Worm   794 EFASPDEEMKKIVLKVVKQCCATDGVEASYIRDEVLPSFFKAFWNQRMAMDRRNYRQLVDTTVEI 858

  Fly   877 ANKVGASEIINRVVDDLKDENEQYRKMVMETVEKIMGNLGAADIDSRLEEQLIDGILYAFQEQTT 941
            |.|||..|:|.|:||||||||||||||||||:|.|:...||.|||:|||||||||:||||||||.
 Worm   859 AQKVGCVEMIARIVDDLKDENEQYRKMVMETIENIVALQGATDIDARLEEQLIDGLLYAFQEQTQ 923

  Fly   942 EDVVMLNGFGTIVNQLGKRVKPYLPQICGTILWRLNNKSAKVRQQAADLISRIAVVMKTCQEEKL 1006
            ||.|||:|||||.:.||:|.|.|:||||||||||||||||||||||||||:|||.||..|:|||:
 Worm   924 EDSVMLDGFGTICSSLGRRAKAYIPQICGTILWRLNNKSAKVRQQAADLIARIAPVMHMCEEEKM 988

  Fly  1007 MGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMTKMTPPIKDLLPRLTPILKNRHEKVQENC 1071
            |||:||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||
 Worm   989 MGHMGVVLYEYLGEEYPEVLGSILGALKAICNVIGMTKMTPPIKDLLPRLTPILKNRHEKVQENC 1053

  Fly  1072 IDLVGRIADRGPEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNN 1136
            |||||.|||||.|:||||||||||||||||||||||:||||.:||||:|||||||||||||||||
 Worm  1054 IDLVGAIADRGSEFVSAREWMRICFELLELLKAHKKSIRRAAINTFGFIAKAIGPHDVLATLLNN 1118

  Fly  1137 LKVQERQNRVCTTVAIAIVAESCRPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDY 1201
            |||||||.|||||||||||:|:|.|||||||:||||||||:||||||||:|||:|||||||.|||
 Worm  1119 LKVQERQLRVCTTVAIAIVSETCAPFTVLPAIMNEYRVPEINVQNGVLKALSFMFEYIGEMAKDY 1183

  Fly  1202 IYAVCPLLEDALMDRDLVHRQTACSAIKHMSLGVYGFGCEDALTHLLNYVWPNIFETSPHLVQAF 1266
            ||||.|||.||||:||.||||.|..|:.|:::|||||||||||.|||||||||:.|.||||:|.:
 Worm  1184 IYAVVPLLIDALMERDQVHRQIAVDAVAHLAIGVYGFGCEDALIHLLNYVWPNMLENSPHLIQRW 1248

  Fly  1267 MDSVDGLRVSLGPIKILQYTLQGLFHPARKVRDVYWKIYNSLYIGGQDALIAGYPRITNDPKNQY 1331
            :.:.:|:||||||||:|||.||.|:|||||||:..||::|:|.:|..|||||.||||.|.|.|||
 Worm  1249 VFACEGMRVSLGPIKVLQYCLQALWHPARKVREPVWKVFNNLILGSADALIAAYPRIENTPTNQY 1313

  Fly  1332 ERYELDYTL 1340
            .||||||.|
 Worm  1314 VRYELDYNL 1322

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sf3b1NP_001259837.1 SF3b1 340..477 CDD:286064 88/139 (63%)
HSH155 483..1340 CDD:227508 698/857 (81%)
HEAT repeat 500..521 CDD:293787 14/20 (70%)
HEAT repeat 533..560 CDD:293787 18/26 (69%)
HEAT repeat 570..598 CDD:293787 24/27 (89%)
HEAT repeat 609..635 CDD:293787 23/25 (92%)
HEAT repeat 642..670 CDD:293787 26/27 (96%)
HEAT repeat 680..709 CDD:293787 27/28 (96%)
HEAT repeat 805..830 CDD:293787 23/24 (96%)
HEAT repeat 886..910 CDD:293787 20/23 (87%)
HEAT repeat 924..955 CDD:293787 26/30 (87%)
HEAT_EZ 947..994 CDD:290247 37/46 (80%)
HEAT repeat 967..1000 CDD:293787 30/32 (94%)
HEAT repeat 1009..1035 CDD:293787 24/25 (96%)
ARM 1016..1117 CDD:237987 93/100 (93%)
HEAT repeat 1049..1078 CDD:293787 28/28 (100%)
HEAT repeat 1098..1119 CDD:293787 17/20 (85%)
HEAT repeat 1129..1157 CDD:293787 26/27 (96%)
HEAT repeat 1163..1193 CDD:293787 25/29 (86%)
HEAT repeat 1204..1230 CDD:293787 17/25 (68%)
sftb-1NP_497853.1 DUF5585 185..477 CDD:375359 149/336 (44%)
SF3b1 316..444 CDD:370189 85/133 (64%)
HSH155 480..1319 CDD:227508 690/838 (82%)
HEAT repeat 624..652 CDD:293787 26/27 (96%)
HEAT repeat 662..691 CDD:293787 27/28 (96%)
HEAT repeat 868..892 CDD:293787 20/23 (87%)
HEAT repeat 906..937 CDD:293787 26/30 (87%)
HEAT repeat 949..979 CDD:293787 28/29 (97%)
HEAT repeat 991..1017 CDD:293787 24/25 (96%)
HEAT repeat 1031..1060 CDD:293787 28/28 (100%)
HEAT repeat 1072..1105 CDD:293787 28/32 (88%)
HEAT repeat 1114..1136 CDD:293787 20/21 (95%)
HEAT repeat 1145..1172 CDD:293787 23/26 (88%)
HEAT repeat 1186..1212 CDD:293787 17/25 (68%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160164640
Domainoid 1 1.000 1267 1.000 Domainoid score I1
eggNOG 1 0.900 - - E1_COG5181
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H6696
Inparanoid 1 1.050 1704 1.000 Inparanoid score I30
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53897
OrthoDB 1 1.010 - - D245208at2759
OrthoFinder 1 1.000 - - FOG0004708
OrthoInspector 1 1.000 - - oto19758
orthoMCL 1 0.900 - - OOG6_101702
Panther 1 1.100 - - LDO PTHR12097
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1324
SonicParanoid 1 1.000 - - X3309
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1716.800

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