DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sf3b1 and sf3b1

DIOPT Version :9

Sequence 1:	NP_001259837.1	Gene:	Sf3b1 / 33235	FlyBaseID:	FBgn0031266	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	XP_031749463.1	Gene:	sf3b1 / 100127558	XenbaseID:	XB-GENE-959867	Length:	1303	Species:	Xenopus tropicalis

Alignment Length:	1369	Identity:	1046/1369 - (76%)
Similarity:	1136/1369 - (82%)	Gaps:	95/1369 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MENIPRTHEDIEAQISVIQEKKTELAKTTAAAAGVGLLDSGGFFDSDLYDDDAAKGKGRYEGYNT 65
            |..|.:|||||||||..||.||..|.:|    .||| |||.|::|.::|    .....|:.||.|
Frog     1 MAKIAKTHEDIEAQIREIQGKKVALDET----QGVG-LDSTGYYDQEIY----GGSDSRFTGYVT 56

  Fly    66 SIAANDAEEVDEDEDD--GFPVPQKRTTYTAPASVLKDVTQGKEDVDPMADRRRPTIADREDEYR 128
            |||||   |.|:|:||  .....||:..|.||.::|.|:.|..|..||.|:.|...||:|||||:
Frog    57 SIAAN---EQDDDDDDISSATFEQKKPGYHAPVALLNDIPQSTEQYDPFAEHRPQKIANREDEYK 118

  Fly   129 QKRRHIIISPERADPFADGGKTPD--VGSRTYTDIMREQMLKGEESELRRRILEKTKEGTLVKTV 191
            |.||.:||||||.|||||||||||  :.:||:.|:|:||.|..||.|:|::|.||.|.|.| |.|
Frog   119 QHRRKMIISPERLDPFADGGKTPDPKINARTFKDVMQEQYLTKEEREIRQQIAEKAKSGDL-KVV 182

  Fly   192 TSSSTSNGDLPAPKDGGRKRGRWDQTVSDSFIPAKMATPSSAATP----TWE--DKTPGDH---- 246
            ..||.|.   |..|   ||| |||||...        ||.|  ||    :|:  :.||| |
Frog   183 NGSSASQ---PPSK---RKR-RWDQTADQ--------TPGS--TPKKLSSWDQAEVTPG-HTPSL 229

  Fly   247 RWDETPGH-KGSETPGATPGLGTRIWDATPAHAV----------TPGHETPGHE---KSARRNRW 297
            |||||||. ||:|||||||  |::|||.||:|..          ||||.||||.   .|||:|||
Frog   230 RWDETPGRAKGNETPGATP--GSKIWDPTPSHTPSGAATPGRGDTPGHATPGHSGATSSARKNRW 292

  Fly   298 DETPKTERETPGH-SGWAETPKPDRTGSGGGAESISIESTPGASKRRSRWDETPSNATPAITPTN 361
            ||||||||:|||| |||||||:.||     |.:||....|||||||:|||||||
Frog   293 DETPKTERDTPGHGSGWAETPRTDR-----GGDSIGETPTPGASKRKSRWDETP----------- 341

  Fly   362 ASAMTPNMTPSMTPHVTPGHATPMLTPGGSTPIGVKAMAMATPSAGALAAMTPEQLQAYRWEKEI 426
            ||.|              |.:||:||| |.||||..||.||||:.|.:.:||||||||:|||:||
Frog   342 ASQM--------------GGSTPVLTP-GKTPIGTPAMNMATPTPGHIMSMTPEQLQAWRWEREI 391

  Fly   427 DERNRPYTDEELDQIFPPGYKILPPPAGYVPLRTPGRKLMATPTPIAGTPAGFFIQVEDKNAKFM 491
            ||||||.:|||||.:||.|||:|||||||||:|||.|||.|||||:.|. .||.:..||:..|.:
Frog   392 DERNRPLSDEELDAMFPEGYKVLPPPAGYVPIRTPARKLTATPTPLGGL-TGFHMPTEDRTMKSV 455

  Fly   492 DNQPKGQNLPFMKPEDAQYFDKLLVDVNEDSLSPEELKERKIMKLLLTIKNGSPPMRKSALRQIT 556
            .:||.| ||||:||:|.||||||||||:|.:|||||.||||||||||.||||:|||||:||||||
Frog   456 SDQPSG-NLPFLKPDDIQYFDKLLVDVDESTLSPEEQKERKIMKLLLKIKNGTPPMRKAALRQIT 519

  Fly   557 DKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRVLYKLDDLVRPYVHKILVVIEPLLIDE 621
            ||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||
Frog   520 DKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDE 584

  Fly   622 DHYARIEGREIISNLAKAAGLATMISTMRPDIDNIDEYVRNTTARAFAVVASALGIPSLLPFLKA 686
            |:|||:||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||
Frog   585 DYYARVEGREIISNLAKAAGLATMISTMRPDIDNMDEYVRNTTARAFAVVASALGIPSLLPFLKA 649

  Fly   687 VCKSKKSWQARHTGIKIVQQIAILMGCAILPHLKALVEIIEHGLVDEQQKVRTITALAIAALAEA 751
            |||||||||||||||||||||||||||||||||::|||||||||||||||||||:||||||||||
Frog   650 VCKSKKSWQARHTGIKIVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAALAEA 714

  Fly   752 ATPYGIESFDSVLKPLWKGIRTHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSP 816
            |||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||
Frog   715 ATPYGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSP 779

  Fly   817 DEEMKKIVLKVVKQCCATDGVEPQYIKEEILPHFFKFFWNHRMALDRRNYRQLVDTTVEIANKVG 881
            ||||||||||||||||.|||||..|||.||||.|||.||.|||||||||||||||||||:|||||
Frog   780 DEEMKKIVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVELANKVG 844

  Fly   882 ASEIINRVVDDLKDENEQYRKMVMETVEKIMGNLGAADIDSRLEEQLIDGILYAFQEQTTEDVVM 946
            |:|||:|:|||||||.||||||||||:|||||||||||||.:||||||||||||||||||||.||
Frog   845 AAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADIDHKLEEQLIDGILYAFQEQTTEDSVM 909

  Fly   947 LNGFGTIVNQLGKRVKPYLPQICGTILWRLNNKSAKVRQQAADLISRIAVVMKTCQEEKLMGHLG 1011
            ||||||:||.|||||||||||||||:|||||||||||||||||||||.|||||||||||||||||
Frog   910 LNGFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLG 974

  Fly  1012 VVLYEYLGEEYPEVLGSILGALKAIVNVIGMTKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVG 1076
            |||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||
Frog   975 VVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVG 1039

  Fly  1077 RIADRGPEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQE 1141
            ||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog  1040 RIADRGAEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQE 1104

  Fly  1142 RQNRVCTTVAIAIVAESCRPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVC 1206
            ||||||||||||||||:|.|||||||||||||||||||||||||||||||||||||||||||||.
Frog  1105 RQNRVCTTVAIAIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVT 1169

  Fly  1207 PLLEDALMDRDLVHRQTACSAIKHMSLGVYGFGCEDALTHLLNYVWPNIFETSPHLVQAFMDSVD 1271
            ||||||||||||||||||.:.::|||||||||||||:|.|||||||||:||||||::||.|.:::
Frog  1170 PLLEDALMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALE 1234

  Fly  1272 GLRVSLGPIKILQYTLQGLFHPARKVRDVYWKIYNSLYIGGQDALIAGYPRITNDPKNQYERYEL 1336
            ||||::||.::|||.|||||||||||||||||||||:|||.||||||.||||.||.||.|.||||
Frog  1235 GLRVAIGPCRMLQYCLQGLFHPARKVRDVYWKIYNSIYIGSQDALIAHYPRIYNDEKNTYIRYEL 1299

  Fly  1337 DYTL 1340
            ||.|
Frog  1300 DYIL 1303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sf3b1	NP_001259837.1	SF3b1	340..477	CDD:286064	81/136 (60%)
		HSH155	483..1340	CDD:227508	775/856 (91%)
		HEAT repeat	500..521	CDD:293787	16/20 (80%)
		HEAT repeat	533..560	CDD:293787	23/26 (88%)
		HEAT repeat	570..598	CDD:293787	26/27 (96%)
		HEAT repeat	609..635	CDD:293787	23/25 (92%)
		HEAT repeat	642..670	CDD:293787	26/27 (96%)
		HEAT repeat	680..709	CDD:293787	28/28 (100%)
		HEAT repeat	805..830	CDD:293787	24/24 (100%)
		HEAT repeat	886..910	CDD:293787	19/23 (83%)
		HEAT repeat	924..955	CDD:293787	28/30 (93%)
		HEAT_EZ	947..994	CDD:290247	43/46 (93%)
		HEAT repeat	967..1000	CDD:293787	30/32 (94%)
		HEAT repeat	1009..1035	CDD:293787	25/25 (100%)
		ARM	1016..1117	CDD:237987	98/100 (98%)
		HEAT repeat	1049..1078	CDD:293787	28/28 (100%)
		HEAT repeat	1098..1119	CDD:293787	20/20 (100%)
		HEAT repeat	1129..1157	CDD:293787	27/27 (100%)
		HEAT repeat	1163..1193	CDD:293787	29/29 (100%)
		HEAT repeat	1204..1230	CDD:293787	20/25 (80%)
sf3b1	XP_031749463.1	CTD	234..381	CDD:215026	95/179 (53%)
		SF3b1	331..441	CDD:401026	81/136 (60%)
		HSH155	445..1303	CDD:227508	775/858 (90%)
		HEAT repeat	463..484	CDD:293787	16/20 (80%)
		HEAT repeat	496..523	CDD:293787	23/26 (88%)
		HEAT repeat	533..561	CDD:293787	26/27 (96%)
		HEAT repeat	572..598	CDD:293787	23/25 (92%)
		HEAT repeat	609..634	CDD:293787	23/24 (96%)
		HEAT repeat	849..873	CDD:293787	19/23 (83%)
		HEAT repeat	887..918	CDD:293787	28/30 (93%)
		HEAT repeat	930..963	CDD:293787	30/32 (94%)
		HEAT repeat	972..998	CDD:293787	25/25 (100%)
		HEAT repeat	1012..1041	CDD:293787	28/28 (100%)
		HEAT repeat	1053..1086	CDD:293787	32/32 (100%)
		HEAT repeat	1095..1117	CDD:293787	21/21 (100%)
		HEAT repeat	1128..1160	CDD:293787	31/31 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1346	1.000	Domainoid score	I7
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H6696
Inparanoid	1	1.050	1966	1.000	Inparanoid score	I56
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245208at2759
OrthoFinder	1	1.000	-	-		FOG0004708
OrthoInspector	1	1.000	-	-		oto103009
Panther	1	1.100	-	-	LDO	PTHR12097
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3309
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160