DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nle and RSA4

DIOPT Version :9

Sequence 1:NP_477294.2 Gene:Nle / 33234 FlyBaseID:FBgn0021874 Length:488 Species:Drosophila melanogaster
Sequence 2:NP_009997.2 Gene:RSA4 / 850435 SGDID:S000000668 Length:515 Species:Saccharomyces cerevisiae


Alignment Length:519 Identity:222/519 - (42%)
Similarity:316/519 - (60%) Gaps:45/519 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 AKKQKMQETDTEQEAT------PHTIQARLVSDTGEEAGPPIDLPAGITTQQLGLICNALL-KNE 60
            :|||| :|....:|..      |:........|||:..|..:.:|..|:.:||..:.|.|. .::
Yeast     9 SKKQK-KEAQLPREVAIIPKDLPNVSIKFQALDTGDNVGGALRVPGAISEKQLEELLNQLNGTSD 72

  Fly    61 EATPYLFFV------GEDEIKKSLEDTLDLAS-----------VDTENVIDIVYQPQAVFKVRPV 108
            :..||.|..      ..|.:|     |:|:..           ..||:.|.::|.|:|||||:||
Yeast    73 DPVPYTFSCTIQGKKASDPVK-----TIDITDNLYSSLIKPGYNSTEDQITLLYTPRAVFKVKPV 132

  Fly   109 TRCTSSMPGHAEAVVSLNFSP-DGAHLASGSGDTTVRLWDLNTETPHFTCTGHKQWVLCVSWAPD 172
            ||.:|::.||...::...|:| ..:.:.:|:||.|.|:||.:|:||..|..||..|||||||:||
Yeast   133 TRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPD 197

  Fly   173 GKRLASGCKAGSIIIWDPETGQQKGRPLSGHKKHINCLAWEPYH--RDPECRKLASASGDGDCRI 235
            |:.:|:|....:|.:|||::||..|..|.||.|.|..|:|||.|  :.....:|||:|.||..:|
Yeast   198 GEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKI 262

  Fly   236 WDVKLGQCLMNIAGHTNAVTAVRWGGAGLIYTSSKDRTVKMWRA-ADGILCRTFSGHAHWVNNIA 299
            ||.....|...::||||:|:.|:|||.||:|:.|.||||::|.. :.|........||||||:::
Yeast   263 WDTVSRVCQYTMSGHTNSVSCVKWGGQGLLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLS 327

  Fly   300 LSTDYVLRTGPF-HPVKDRSKSHLSLSTEELQESALKRYQAVCP---DEVESLVSCSDDNTLYLW 360
            |||||.||.|.| |..|..|      :.||.|:.||:.|:.:|.   :..|.:|:.|||.|::||
Yeast   328 LSTDYALRIGAFDHTGKKPS------TPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLW 386

  Fly   361 RN-NQNKCVERMTGHQNVVNDVKYSPDVKLIASASFDKSVRLWRASDGQYMATFRGHVQAVYTVA 424
            .. ...|.:.||||||.:||.|.:|||.:.|.|||||.|::||...||::::||||||.:||.||
Yeast   387 NPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFRGHVASVYQVA 451

  Fly   425 WSADSRLIVSGSKDSTLKVWSVQTKKLAQELPGHADEVFGVDWAPDGSRVASGGKDKVIKLWAY 488
            ||:|.||:||.|||:|||||.|:|:||:.:||||.|||:.|||:.||.||.||||||:::||.:
Yeast   452 WSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLWTH 515

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NleNP_477294.2 NLE 22..82 CDD:285380 15/66 (23%)
WD40 110..147 CDD:278812 11/37 (30%)
WD40 112..486 CDD:225201 182/382 (48%)
WD40 repeat 123..159 CDD:293791 13/36 (36%)
WD40 153..487 CDD:238121 169/341 (50%)
WD40 repeat 164..202 CDD:293791 19/37 (51%)
WD40 repeat 208..249 CDD:293791 15/42 (36%)
WD40 repeat 254..289 CDD:293791 15/35 (43%)
WD40 repeat 296..372 CDD:293791 30/80 (38%)
WD40 repeat 378..414 CDD:293791 18/35 (51%)
WD40 repeat 420..456 CDD:293791 23/35 (66%)
WD40 repeat 462..486 CDD:293791 14/23 (61%)
RSA4NP_009997.2 NLE 32..>79 CDD:400462 12/46 (26%)
WD40 135..472 CDD:238121 157/342 (46%)
WD40 repeat 189..227 CDD:293791 19/37 (51%)
WD40 repeat 233..276 CDD:293791 15/42 (36%)
WD40 repeat 281..316 CDD:293791 15/34 (44%)
WD40 repeat 324..399 CDD:293791 30/80 (38%)
WD40 repeat 405..441 CDD:293791 18/35 (51%)
WD40 repeat 447..483 CDD:293791 23/35 (66%)
WD40 475..513 CDD:197651 23/37 (62%)
WD40 repeat 489..513 CDD:293791 14/23 (61%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157343037
Domainoid 1 1.000 62 1.000 Domainoid score I2494
eggNOG 1 0.900 - - E1_KOG0271
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H5494
Inparanoid 1 1.050 418 1.000 Inparanoid score I293
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53974
OrthoFinder 1 1.000 - - FOG0005114
OrthoInspector 1 1.000 - - oto98973
orthoMCL 1 0.900 - - OOG6_101916
Panther 1 1.100 - - LDO PTHR19848
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R814
SonicParanoid 1 1.000 - - X3634
TreeFam 1 0.960 - -
1514.790

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