Protein Alignment Nle and nle1

DIOPT Version :10

• Sequence 1: NP_477294.2
• Gene: Nle / 33234
• FlyBaseID: FBgn0021874
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: XP_031751981.1
• Gene: nle1 / 779995
• XenbaseID: XB-GENE-984059
• Length: 502
• Species: Xenopus tropicalis
• Alignment Length: 461
• Identity: 286/461 - (62%)
• Similarity: 349/461 - (75%)
• Gaps: 4/461 - (0%)

  Fly    29 DTGEEAGPPIDLPAGITTQQLGLICNALLKNEEATPYLFFVGEDEIKKSLEDTLDLASVDTENVI 93
            :.||..|.|.|:|..||:.:|.|:|||||:.||..|..|||.:.||..||:.||:..||:||.||
 Frog    41 ENGEVLGSPFDVPVDITSDKLQLVCNALLQEEEPVPLAFFVHDLEIVTSLDKTLEKQSVETEKVI 105

  Fly    94 DIVYQPQAVFKVRPVTRCTSSMPGHAEAVVSLNFSPDGAHLASGSGDTTVRLWDLNTETPHFTCT 158
            ||:||||||||||.|||||||:.||.|||:|:.|||.|.:|||||||||||.|||||||||||..
 Frog   106 DIIYQPQAVFKVRAVTRCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLNTETPHFTSK 170

  Fly   159 GHKQWVLCVSWAPDGKRLASGCKAGSIIIWDPETGQQKGRPLSGHKKHINCLAWEPYHRDPECRK 223
            ||..|:|.::|:|||::||||||...|.||||.||:|.|:||:||.|.|..|.|||.|.:||||.
 Frog   171 GHTHWILSIAWSPDGRKLASGCKNSQIFIWDPNTGKQIGKPLTGHSKWITWLCWEPLHLNPECRY 235

  Fly   224 LASASGDGDCRIWDVKLGQCLMNIAGHTNAVTAVRWGGAGLIYTSSKDRTVKMWRAADGILCRTF 288
            |||||.|...||||..:|||...:..||.:||||:|||.||:|:||:|||:|.|||.||:||||.
 Frog   236 LASASKDCTIRIWDTVMGQCQKILTSHTQSVTAVKWGGDGLLYSSSQDRTIKAWRAQDGVLCRTL 300

  Fly   289 SGHAHWVNNIALSTDYVLRTGPFHPVKDRS--KSHLSLSTEELQESALKRYQAVCPDEVESLVSC 351
            .|||||||.:|||||||||||.|:|. |.|  ...:|.|.|:|:|.|||||..|.....|.|||.
 Frog   301 QGHAHWVNTMALSTDYVLRTGAFNPA-DASVNPQDMSGSLEDLKEKALKRYNEVRGQGPERLVSG 364

  Fly   352 SDDNTLYLWR-NNQNKCVERMTGHQNVVNDVKYSPDVKLIASASFDKSVRLWRASDGQYMATFRG 415
            |||.||:||. ..:.|.::||||||.::|:|.:|||.::||||||||||:||....|:::|:.||
 Frog   365 SDDFTLFLWAPAEEKKPLQRMTGHQALINEVLFSPDTRIIASASFDKSVKLWDGKTGKFLASLRG 429

  Fly   416 HVQAVYTVAWSADSRLIVSGSKDSTLKVWSVQTKKLAQELPGHADEVFGVDWAPDGSRVASGGKD 480
            ||.|||.:||||||||:||||.|||||||..:||||..:||||||||:.|||:|||.||||||||
 Frog   430 HVSAVYQIAWSADSRLLVSGSSDSTLKVWDSKTKKLLVDLPGHADEVYSVDWSPDGQRVASGGKD 494

  Fly   481 KVIKLW 486
            |.:::|
 Frog   495 KCLRIW 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nle	NP_477294.2	NLE	22..82	CDD:462380	25/52 (48%)
		WD40	84..486	CDD:441893	258/404 (64%)
		WD40 repeat	123..159	CDD:293791	27/35 (77%)
		WD40 repeat	164..202	CDD:293791	22/37 (59%)
		WD40 repeat	208..249	CDD:293791	22/40 (55%)
		WD40 repeat	254..289	CDD:293791	25/34 (74%)
		WD40 repeat	296..372	CDD:293791	40/78 (51%)
		WD40 repeat	378..414	CDD:293791	19/35 (54%)
		WD40 repeat	420..456	CDD:293791	25/35 (71%)
		WD40 repeat	462..486	CDD:293791	16/23 (70%)
nle1	XP_031751981.1	NLE	34..94	CDD:462380	25/52 (48%)
		WD40	118..501	CDD:441893	242/384 (63%)
		WD40 repeat	136..171	CDD:293791	27/34 (79%)
		WD40 repeat	176..214	CDD:293791	22/37 (59%)
		WD40 repeat	220..261	CDD:293791	22/40 (55%)
		WD40 repeat	266..301	CDD:293791	25/34 (74%)
		WD40 repeat	308..386	CDD:293791	40/78 (51%)
		WD40 repeat	392..428	CDD:293791	19/35 (54%)
		WD40 repeat	434..470	CDD:293791	25/35 (71%)
		WD40 repeat	476..500	CDD:293791	16/23 (70%)