DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nle and NLE1

DIOPT Version :9

Sequence 1:NP_477294.2 Gene:Nle / 33234 FlyBaseID:FBgn0021874 Length:488 Species:Drosophila melanogaster
Sequence 2:NP_060566.2 Gene:NLE1 / 54475 HGNCID:19889 Length:485 Species:Homo sapiens


Alignment Length:476 Identity:278/476 - (58%)
Similarity:353/476 - (74%) Gaps:5/476 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 EATPHTIQARLV---SDTGEEAGPPIDLPAGITTQQLGLICNALLKNEEATPYLFFVGEDEIKKS 77
            ||....:|..||   .:.|:..|.|.|:|..||..:|.|:|||||..|:..|..|||.:.||..|
Human     8 EAVARDVQRLLVQFQDEGGQLLGSPFDVPVDITPDRLQLVCNALLAQEDPLPLAFFVHDAEIVSS 72

  Fly    78 LEDTLDLASVDTENVIDIVYQPQAVFKVRPVTRCTSSMPGHAEAVVSLNFSPDGAHLASGSGDTT 142
            |..||:..:|:||.|:||:|||||:|:||.|||||||:.||:|||:|:.|||.|.:|||||||||
Human    73 LGKTLESQAVETEKVLDIIYQPQAIFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTT 137

  Fly   143 VRLWDLNTETPHFTCTGHKQWVLCVSWAPDGKRLASGCKAGSIIIWDPETGQQKGRPLSGHKKHI 207
            ||.|||:||||||||.||:.|||.:||:|||::||||||.|.|::|||.||:|.||.|:||.|.|
Human   138 VRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWI 202

  Fly   208 NCLAWEPYHRDPECRKLASASGDGDCRIWDVKLGQCLMNIAGHTNAVTAVRWGGAGLIYTSSKDR 272
            ..|:|||.|.:||||.:||:|.||..||||...|:|...:.|||.:||.:||||.||:|::|:||
Human   203 TGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDR 267

  Fly   273 TVKMWRAADGILCRTFSGHAHWVNNIALSTDYVLRTGPFHPVK-DRSKSHLSLSTEELQESALKR 336
            |:|:|||.||:||||..||.||||.:||||||.||||.|.|.: ..:...|..|.:||:|.||.|
Human   268 TIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSR 332

  Fly   337 YQAVCPDEVESLVSCSDDNTLYLWRNNQN-KCVERMTGHQNVVNDVKYSPDVKLIASASFDKSVR 400
            |..|.....|.|||.|||.||:||...:: |.:.||||||.::|.|.:|||.:::||||||||::
Human   333 YNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIK 397

  Fly   401 LWRASDGQYMATFRGHVQAVYTVAWSADSRLIVSGSKDSTLKVWSVQTKKLAQELPGHADEVFGV 465
            ||....|:|:|:.||||.|||.:||||||||:||||.|||||||.|:.:|||.:||||||||:.|
Human   398 LWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAV 462

  Fly   466 DWAPDGSRVASGGKDKVIKLW 486
            ||:|||.|||||||||.:::|
Human   463 DWSPDGQRVASGGKDKCLRIW 483

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NleNP_477294.2 NLE 22..82 CDD:285380 26/62 (42%)
WD40 110..147 CDD:278812 26/36 (72%)
WD40 112..486 CDD:225201 229/375 (61%)
WD40 repeat 123..159 CDD:293791 27/35 (77%)
WD40 153..487 CDD:238121 200/336 (60%)
WD40 repeat 164..202 CDD:293791 24/37 (65%)
WD40 repeat 208..249 CDD:293791 20/40 (50%)
WD40 repeat 254..289 CDD:293791 23/34 (68%)
WD40 repeat 296..372 CDD:293791 36/77 (47%)
WD40 repeat 378..414 CDD:293791 18/35 (51%)
WD40 repeat 420..456 CDD:293791 25/35 (71%)
WD40 repeat 462..486 CDD:293791 16/23 (70%)
NLE1NP_060566.2 Ubiquitin-like (UBL) domain. /evidence=ECO:0000250|UniProtKB:P25382 14..96 37/81 (46%)
NLE 17..77 CDD:285380 25/59 (42%)
WD40 106..484 CDD:238121 231/378 (61%)
WD40 107..485 CDD:225201 230/377 (61%)
WD 1. /evidence=ECO:0000255 112..151 29/38 (76%)
WD 2. /evidence=ECO:0000255 154..193 24/38 (63%)
WD40 repeat 159..197 CDD:293791 24/37 (65%)
WD 3. /evidence=ECO:0000255 197..241 24/43 (56%)
WD40 repeat 203..244 CDD:293791 20/40 (50%)
WD 4. /evidence=ECO:0000255 244..282 24/37 (65%)
WD40 repeat 249..284 CDD:293791 23/34 (68%)
WD40 repeat 291..369 CDD:293791 36/77 (47%)
WD 5. /evidence=ECO:0000255 325..366 19/40 (48%)
WD 6. /evidence=ECO:0000255 370..409 20/38 (53%)
WD40 repeat 375..411 CDD:293791 18/35 (51%)
WD 7. /evidence=ECO:0000255 412..451 29/38 (76%)
WD40 repeat 417..453 CDD:293791 25/35 (71%)
WD 8. /evidence=ECO:0000255 454..485 22/30 (73%)
WD40 repeat 459..483 CDD:293791 16/23 (70%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144503
Domainoid 1 1.000 90 1.000 Domainoid score I7820
eggNOG 1 0.900 - - E1_KOG0271
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H5494
Inparanoid 1 1.050 587 1.000 Inparanoid score I1001
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53974
OrthoDB 1 1.010 - - D346056at33208
OrthoFinder 1 1.000 - - FOG0005114
OrthoInspector 1 1.000 - - oto88394
orthoMCL 1 0.900 - - OOG6_101916
Panther 1 1.100 - - LDO PTHR19848
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R814
SonicParanoid 1 1.000 - - X3634
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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