Protein Alignment Nle and Nle1

DIOPT Version :10

• Sequence 1: NP_477294.2
• Gene: Nle / 33234
• FlyBaseID: FBgn0021874
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: NP_663406.2
• Gene: Nle1 / 217011
• MGIID: 2429770
• Length: 485
• Species: Mus musculus
• Alignment Length: 477
• Identity: 277/477 - (58%)
• Similarity: 352/477 - (73%)
• Gaps: 5/477 - (1%)

  Fly    15 QEATPHTIQARLV---SDTGEEAGPPIDLPAGITTQQLGLICNALLKNEEATPYLFFVGEDEIKK 76
            :||....:|..||   .:.|:..|.|.|:|..||..:|.|:|||||..||..|..|:|.:.||..
Mouse     7 EEAAAGDVQRLLVQFQDEGGQLLGSPFDVPVDITPDKLQLVCNALLAQEEPLPLAFYVHDAEIVS 71

  Fly    77 SLEDTLDLASVDTENVIDIVYQPQAVFKVRPVTRCTSSMPGHAEAVVSLNFSPDGAHLASGSGDT 141
            ||..||:..||:||.::||:|||||||:||.|||||||:.||:|||:|:.|||.|.:||||||||
Mouse    72 SLGKTLESQSVETEKIVDIIYQPQAVFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDT 136

  Fly   142 TVRLWDLNTETPHFTCTGHKQWVLCVSWAPDGKRLASGCKAGSIIIWDPETGQQKGRPLSGHKKH 206
            |||.|||:||||||||.||:.|||.:||:||||:||||||.|.:::|||.||.|.||.|:||.|.
Mouse   137 TVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWDPSTGLQVGRTLTGHSKW 201

  Fly   207 INCLAWEPYHRDPECRKLASASGDGDCRIWDVKLGQCLMNIAGHTNAVTAVRWGGAGLIYTSSKD 271
            |..|:|||.|.:||||.:||:|.||..|:||...|:|...:.|||.:||.:||||.||:|::|:|
Mouse   202 ITGLSWEPLHMNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQD 266

  Fly   272 RTVKMWRAADGILCRTFSGHAHWVNNIALSTDYVLRTGPFHPVKDR-SKSHLSLSTEELQESALK 335
            ||:|:|||.||:||||..||.||||.:||||||.||||.|.|.:.. :...|..|.:||:|.|..
Mouse   267 RTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEATVNAQDLQGSLKELKERASS 331

  Fly   336 RYQAVCPDEVESLVSCSDDNTLYLWRNNQN-KCVERMTGHQNVVNDVKYSPDVKLIASASFDKSV 399
            ||..|.....|.|||.|||.||:||...:: |.:.||||||.::|.|.:|||.:::||||||||:
Mouse   332 RYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLARMTGHQALINQVLFSPDSRIVASASFDKSI 396

  Fly   400 RLWRASDGQYMATFRGHVQAVYTVAWSADSRLIVSGSKDSTLKVWSVQTKKLAQELPGHADEVFG 464
            :||....|:|:|:.||||.|||.:||||||||:||||.|||||||.|:.:|||.:||||||||:.
Mouse   397 KLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLATDLPGHADEVYA 461

  Fly   465 VDWAPDGSRVASGGKDKVIKLW 486
            |||:|||.|||||||||.:::|
Mouse   462 VDWSPDGQRVASGGKDKCLRIW 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nle	NP_477294.2	NLE	22..82	CDD:462380	26/62 (42%)
		WD40	84..486	CDD:441893	246/403 (61%)
		WD40 repeat	123..159	CDD:293791	27/35 (77%)
		WD40 repeat	164..202	CDD:293791	24/37 (65%)
		WD40 repeat	208..249	CDD:293791	19/40 (48%)
		WD40 repeat	254..289	CDD:293791	23/34 (68%)
		WD40 repeat	296..372	CDD:293791	35/77 (45%)
		WD40 repeat	378..414	CDD:293791	18/35 (51%)
		WD40 repeat	420..456	CDD:293791	25/35 (71%)
		WD40 repeat	462..486	CDD:293791	16/23 (70%)
Nle1	NP_663406.2	NLE	17..77	CDD:462380	25/59 (42%)
		WD40	101..484	CDD:441893	233/383 (61%)
		WD 1	112..151		29/38 (76%)
		WD 2	154..193		24/38 (63%)
		WD40 repeat	159..197	CDD:293791	24/37 (65%)
		WD 3	197..241		23/43 (53%)
		WD40 repeat	203..244	CDD:293791	19/40 (48%)
		WD 4	244..282		24/37 (65%)
		WD40 repeat	249..284	CDD:293791	23/34 (68%)
		WD40 repeat	291..369	CDD:293791	35/77 (45%)
		WD 5	327..366		17/38 (45%)
		WD 6	370..409		20/38 (53%)
		WD40 repeat	375..411	CDD:293791	18/35 (51%)
		WD 7	412..451		29/38 (76%)
		WD40 repeat	417..453	CDD:293791	25/35 (71%)
		WD 8	454..484		22/30 (73%)
		WD40 repeat	459..483	CDD:293791	16/23 (70%)