Protein Alignment CG11835 and SIR4

DIOPT Version :9

• Sequence 1: NP_001259835.1
• Gene: CG11835 / 33232
• FlyBaseID: FBgn0031264
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_010513.1
• Gene: SIR4 / 851813
• SGDID: S000002635
• Length: 1358
• Species: Saccharomyces cerevisiae
• Alignment Length: 712
• Identity: 151/712 - (21%)
• Similarity: 258/712 - (36%)
• Gaps: 202/712 - (28%)

  Fly    29 HQTA---ATDDKKLQ----SSLKKLSVSTIP--GIEEV------NIIKDDLTV--IHFNNPKAQA 76
            ||.:   .|..|:||    |.|||.:.::.|  .:|::      ::::...:.  |..|||...|
Yeast    65 HQPSDVKPTSHKQLQQPKSSPLKKNNYNSFPHSNLEKISNSKLLSLLRSKTSAGRIESNNPSHDA 129

  Fly    77 SLSANTF---AVTGHGE-------TRKVVEMLPDILPQLGQETVVQLRMYANAMNSQKGAPGSGD 131
            |.|..:|   |.:.|.:       ::.|..::|....|.....:                  ||.
Yeast   130 SRSLASFEQTAFSRHAQQQTSTFNSKPVRTIVPISTSQTNNSFL------------------SGV 176

  Fly   132 GPLPAEEDDDVPLLVGDFD-EVAKVE-ATKQPVHE---PKESAEIKA------KDKQQQ----QP 181
            ..|.:||.      :.|:. |:..:. |.:|||.|   .|.||:|.|      |||..:    :.
Yeast   177 KSLLSEEK------IRDYSKEILGINLANEQPVLEKPLKKGSADIGASVISLTKDKSIRKDTVEE 235

  Fly   182 KKEQK----------QSAKVPETT--NPSENPKEKQENKKGQAKNNKKGDPQT-----NKDKTNK 229
            |||:|          .|..||:.:  :...:|:|.:....|.||.|.   .||     |::.||:
Yeast   236 KKEEKLNIGKNFAHSDSLSVPKVSAGDSGISPEESKARSPGIAKPNA---IQTEVYGINEESTNE 297

  Fly   230 SKDQAKGQPAP-QANKETTQAAQALKQN-----------------PSKPAVQQ------------ 264
            ..:..:.:|.. ..|...:..|.||..|                 |.|.|:.|
Yeast   298 RLEINQEKPVKLDENSANSTVASALDTNGTSATTETLTSKKIVPSPKKVAIDQDKITLHDEKTLA 362

  Fly   265 -KKDQVLAVDQKIEANGAIQKAQQPK-PAETKSTDQKVEPKSAEKQVDKAKPIEQTKTKESKVEH 327
             .|.|.:..:||::.:..:::.:..| |..:||...:  |:......:.:...|:|......||:
Yeast   363 PSKHQPITSEQKMKEDADLKRMEILKSPHLSKSPADR--PQGRRNSRNFSTRDEETTKLAFLVEY 425

  Fly   328 ----------PKPAQKQLDQNTQAKPTAERSEAKPVVPTPEPQKSAPPAVQTLAQIVALPAEKPA 382
                      .:..:|:.|.||.||  .:..|.|.:...|      |..:.|.|.:..:..|  .
Yeast   426 EGQENNYNSTSRSTEKKNDMNTSAK--NKNGENKKIGKRP------PEIMSTEAHVNKVTEE--T 480

  Fly   383 NEAVAAPKAEEQK--KDSSGPAKVEPA-----ITPS-APQPVTTAEPPKSALKQDSPPKSAPKQG 439
            .:.:.:.:.:.:|  :...|.:.::..     :||| .||......|.|         |..|.:|
Yeast   481 TKQIQSVRIDGRKVLQKVQGESHIDSRNNTLNVTPSKRPQLGEIPNPMK---------KHKPNEG 536

  Fly   440 SPPK------NVPKQESPPQSA-----PKQDSPPKGAPKQDSPPKGAPKQDSPP---KGAPKQD- 489
            ..|.      |:.|:..|.:..     .|:.|  ..|.|....|....:..:.|   |...|:|
Yeast   537 RTPNISNGTINIQKKLEPKEIVRDILHTKESS--NEAKKTIQNPLNKSQNTALPSTHKVTQKKDI 599

  Fly   490 -----SAPQQKTPPPVKQEVAPAKQDEPPAKQDAPPAKQDAPVPVPEVIKTLAPEVPNVSQAP-- 547
                 ...|.::.|.:..|:     |....|      .:|.||......|:|.....||.:||
Yeast   600 KIGTNDLFQVESAPKISSEI-----DRENVK------SKDEPVSKAVESKSLLNLFSNVLKAPFI 653

  Fly   548 ---AQPQGQAALASEKPADAPKAIEEPKAAPKKESPPPTKPVTAT-------VPVAPATPAE 599
               ::|....||:.||...........|...|.:....::||:|:       .||:.:.|::
Yeast   654 KSESKPFSSDALSKEKANFLETIASTEKPENKTDKVSLSQPVSASKHEYSDNFPVSLSQPSK 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11835	NP_001259835.1	NAC	38..91	CDD:280093	18/76 (24%)
SIR4	NP_010513.1	PTZ00449	<2..>106	CDD:185628	12/40 (30%)
		Sir4p-SID_like	801..893	CDD:259839

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.759104	Normalized mean entropy	S2165
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950